1. Axillary ultrasound for predicting response to neoadjuvant treatment in breast cancer patients : a single institution experienceNina Pišlar, Gorana Gašljević, Maja Marolt-Mušič, Simona Borštnar, Janez Žgajnar, Andraž Perhavec, 2023, izvirni znanstveni članek Ključne besede: breast cancer, neoadjuvant treatment, surgical treatment
Objavljeno v DiRROS: 18.04.2024; Ogledov: 21; Prenosov: 11
 Celotno besedilo (1015,10 KB)
Gradivo ima več datotek! Več... |
2. Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectivenessMaja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Savarin, Urška Kamenšek, Simona Kranjc Brezar, Andrej Cör, Gregor Serša, 2015, izvirni znanstveni članek Povzetek: Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most suitable for clinical use. Intravenous administration of cisplatin for electrochemotherapy is still not widely accepted in the clinics, presumably due to its lower antitumor effectiveness, but adjuvant therapy by immunomodulatory or vascular-targeting agents could provide a way for its potentiation. Hence, the aim of the present study was to explore the possibility of adjuvant tumour necrosis factor % (TNF-%) therapy to potentiate antitumor effectiveness of electrochemotherapy with intravenous cisplatin administration in murine sarcoma. Materials and methods. In vivo study was designed to evaluate the effect of TNF-% applied before or after the electrochemotherapy and to evaluate the effect of adjuvant TNF-% on electrochemotherapy with different cisplatin doses. Results. A synergistic interaction between TNF-% and electrochemotherapy was observed. Administration of TNF-% before the electrochemotherapy resulted in longer tumour growth delay and increased tumour curability, and was significantly more effective than TNF-% administration after the electrochemotherapy. Tumour analysis revealed increased platinum content in tumours, TNF-% induced blood vessel damage and increased tumour necrosis after combination of TNF-% and electrochemotherapy, indicating an anti-vascular action of TNF-%. In addition, immunomodulatory effect might have contributed to curability rate of the tumours. Conclusion. Adjuvant intratumoural TNF-% therapy synergistically contributes to electrochemotherapy with intravenous cisplatin administration. Due to its potentiation at all doses of cisplatin, the combined treatment is predicted to be effective also in tumours, where the drug concentration is suboptimal or in bigger tumours, where electrochemotherapy with intravenous cisplatin is not expected to be sufficiently effective.
Ključne besede: electrochemotherapy, TNF, adjuvant immunotherapy, cisplatin
Objavljeno v DiRROS: 17.04.2024; Ogledov: 42; Prenosov: 5
Celotno besedilo (978,26 KB) |
3. Položaj priseljencev na področju zdravja in zdravstvenega varstva v SlovenijiRomana Bešter, Mojca Medvešek, Janez Pirc, 2020, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Ključne besede: integracija priseljencev, priseljenci, zdravje, zdravstveno varstvo, Slovenija, integracijska politika
Objavljeno v DiRROS: 16.04.2024; Ogledov: 42; Prenosov: 5
Celotno besedilo (2,56 MB) |
4. |
5. Razvoj integracijskih programov za priseljence v SlovenijiMojca Medvešek, Romana Bešter, Janez Pirc, 2020, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Ključne besede: integracija, integracijska politika, integracijski programi, državljani držav nečlanic Evropske unije, začetna integracija priseljencev, slovenski jezik, Slovenija
Objavljeno v DiRROS: 16.04.2024; Ogledov: 46; Prenosov: 8
Celotno besedilo (2,36 MB) |
6. |
7. |
8. |
9. Mnenja večinskega prebivalstva Slovenije o priseljevanju, priseljencih in integracijiMojca Medvešek, Romana Bešter, Janez Pirc, 2022, znanstvena monografija Ključne besede: imigracija, javno mnenje, vladna politika, Slovenija, imigranti, integracija
Objavljeno v DiRROS: 16.04.2024; Ogledov: 49; Prenosov: 6
Celotno besedilo (3,68 MB) |
10. |
