Digitalni repozitorij raziskovalnih organizacij Slovenije

Iskanje po repozitoriju
A+ | A- | Pomoč | SLO | ENG

Iskalni niz: išči po
išči po
išči po
išči po

Možnosti:
  Ponastavi


Iskalni niz: "avtor" (Irena Hočevar-Boltežar) .

1 - 4 / 4
Na začetekNa prejšnjo stran1Na naslednjo stranNa konec
1.
Možnosti rehabilitacije pri bolnikih z rakom glave in vratu
Irena Hočevar-Boltežar, 2022, objavljeni strokovni prispevek na konferenci

Povzetek: Rak glave in vratu je osmi najpogostejši rak v Sloveniji. Zdravimo ga kirurško, z radioterapijo in kemoterapijo, pogosto s kombinacijo teh načinov zdravljenja. Ker pa rak glave in vratu prizadene nos, ustno votlino, žrelo in grlo, so kot posledica bolezni same in nato zdravljenja okvarjene številne pomembne funkcije, ki vključujejo: dihanje, požiranje, govor, kašelj in vohanje. Za čim boljšo rehabilitacijo prizadetih funkcij je treba najprej natančno ugotoviti, kateri organi so prizadeti in kako okvarjeni so ter kakšne so preostale zmožnosti za izvedbo opisanih funkcij. Na podlagi ustreznih preiskav izberemo način rehabilitacije za vsakega bolnika posebej. V diagnostiko okvarjenih funkcij in rehabilitacijo je vključena vrsta različnih strokovnjakov, v rehabilitaciji pa je vodilni ustrezno usposobljen specialist klinične logopedije. Dobra rehabilitacija okvarjenih funkcij omogoča bolniku večjo kakovost življenja.
Ključne besede: rak glave in vratu, požiranje, govor, voh, rehabilitacija
Objavljeno v DiRROS: 06.01.2023; Ogledov: 282; Prenosov: 69
.pdf Celotno besedilo (108,21 KB)

2.
CD3+CD4-CD8- mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps
Tanja Soklič, Mira Šilar, Matija Rijavec, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, kratki znanstveni prispevek

Povzetek: Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP.
Ključne besede: chronic rhinosinusitis, CD3+ T-cells, CD4- T-cells, CD8- T-cells
Objavljeno v DiRROS: 22.10.2020; Ogledov: 1388; Prenosov: 463
URL Povezava na datoteko

3.
Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Tanja Soklič, Matija Rijavec, Mira Šilar, Ana Koren, Izidor Kern, Irena Hočevar-Boltežar, Peter Korošec, 2019, izvirni znanstveni članek

Povzetek: Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Ključne besede: sinusitis, nasal polyps, Th1 cells, Th2 cells, Th17 cells, transcription factors, chronic rhinosinusitis
Objavljeno v DiRROS: 09.10.2020; Ogledov: 1311; Prenosov: 743
.pdf Celotno besedilo (698,54 KB)
Gradivo ima več datotek! Več...

4.
Rehabilitacija bolnikov po operaciji raka v ORL področju
Irena Hočevar-Boltežar, Zora Radšel, 1995, objavljeni strokovni prispevek na konferenci

Ključne besede: onkologija, rak (medicina), zdravljenje, otorinolaringologija, kirurgija, rehabilitacija
Objavljeno v DiRROS: 20.05.2020; Ogledov: 1211; Prenosov: 337
.pdf Celotno besedilo (359,90 KB)

Iskanje izvedeno v 0.28 sek.
Na vrh