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2. Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy : preliminary results of a hybrid approach treatment of pancreatic cancerŽan Čebron, Mihajlo Djokić, Miha Petrič, Maja Čemažar, Maša Omerzel, Gregor Serša, Blaž Trotovšek, 2024, izvirni znanstveni članek Povzetek: Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible.
Ključne besede: pancreatic cancer, intraoperative electrochemotherapy, electroporation
Objavljeno v DiRROS: 04.06.2026; Ogledov: 77; Prenosov: 50
 Celotno besedilo (4,65 MB)
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4. Effect of bleomycin hydrolase expression in tumor tissue on the therapeutic effectiveness of electrochemotherapyJan Bogataj, Urša Lampreht Tratar, Gregor Serša, Maja Čemažar, Aleš Grošelj, Maša Omerzel, 2025, izvirni znanstveni članek Povzetek: Electrochemotherapy (ECT) is a cancer treatment that combines application of short electrical pulses with chemotherapy drugs to improve their delivery into tumor cells. Bleomycin is one of the most effective drugs used in ECT, but its success can vary depending on the tumor type. One possible reason is the presence of bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin. In this study, we measured BLMH levels in different mouse tumor cell lines and tumors grown in animals. Thereafter we compared the levels of BLMH with tumor response to ECT and found a correlation with BLMH content, i.e., tumors with higher BLMH content responded poorly. These findings suggest that levels of BLMH could serve as a predictive marker for ECT effectiveness. Testing for BLMH before treatment may help personalize therapy and identify patients most likely to benefit from ECT.
Ključne besede: electrochemotherapy, bleomycin hydrolase, predictive biomarker, murine models
Objavljeno v DiRROS: 20.04.2026; Ogledov: 193; Prenosov: 150
Celotno besedilo (17,01 MB)
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5. Phase I trial of phIL12 plasmid intratumoral gene electrotransfer in patients with basal cell carcinoma in head and neck regionPrimož Strojan, Tanja Jesenko, Maša Omerzel, Črt Jamšek, Aleš Grošelj, Urša Lampreht Tratar, Boštjan Markelc, Gorana Gašljević, Alojz Ihan, Franc Smrekar, Matjaž Peterka, Maja Čemažar, Gregor Serša, 2025, izvirni znanstveni članek Ključne besede: phase I clinical trial, phIL12 plasmid, interleukin-12, gene electrotransfer, basal cell carcinoma
Objavljeno v DiRROS: 13.04.2026; Ogledov: 194; Prenosov: 154
Celotno besedilo (5,35 MB)
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6. Bleomycin electrosclerotherapy (BEST) : mechanistic parallels to electrochemotherapy, experimental models, and unresolved questionsBarbara Lisec, Maja Čemažar, Tobian Muir, Maša Omerzel, Tanja Jesenko, Boštjan Markelc, Aleš Grošelj, Rok Dežman, Miha Štabuc, Dimitrij Kuhelj, Gregor Serša, 2026, pregledni znanstveni članek Ključne besede: vascular malformations, bleomycin electrosclerotherapy, BEST, electrochemotherapy
Objavljeno v DiRROS: 01.04.2026; Ogledov: 281; Prenosov: 174
Celotno besedilo (2,26 MB)
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7. Učinek kombinacije elektrokemoterapije in anti-pd-1 imunoterapije pri mišjih modelih tumorjev z različnim imunskim statusomSimona Kranjc Brezar, Maša Omerzel, Urša Lampreht Tratar, Tanja Jesenko, Barbara Lisec, Gregor Serša, Maja Čemažar, 2025, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: eksperimentalna onkologija, imunoterapija, elektrokemoterapija
Objavljeno v DiRROS: 18.03.2026; Ogledov: 358; Prenosov: 175
Celotno besedilo (106,92 KB)
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8. Vzpostavitev elektroprenosa sistema transpomnožujočih mRNA na modelu mišjega melanoma B16-F10 in vitro in in vivoJaka Vrevc Žlajpah, Urška Kamenšek, Urša Lampreht Tratar, Maja Čemažar, Gregor Serša, Katja Uršič Valentinuzzi, 2025, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: elektrokemoterapija, eksperimentalna onkologija, melanom
Objavljeno v DiRROS: 18.03.2026; Ogledov: 284; Prenosov: 96
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9. Elektrokemoterapija z bleomicinom, cisplatinom ali oksaliplatinom na mišjih tumorskih modelih : od ablacije do vakcinacije in situKatja Uršič Valentinuzzi, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Tilen Komel, Simon Buček, Maja Čemažar, Gregor Serša, 2025, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: elektrokemoterapija, eksperimentalna onkologija, miši
Objavljeno v DiRROS: 11.03.2026; Ogledov: 369; Prenosov: 122
Celotno besedilo (106,10 KB) |
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