Digitalni repozitorij raziskovalnih organizacij Slovenije

Iskanje po repozitoriju
A+ | A- | Pomoč | SLO | ENG

Iskalni niz: išči po
išči po
išči po
išči po

Možnosti:
  Ponastavi


Iskalni niz: "avtor" (Franc %C5%A0ifrer) .

1 - 10 / 243
Na začetekNa prejšnjo stran12345678910Na naslednjo stranNa konec
1.
The correlation between the levels of tissue inhibitor of metalloproteinases 1 in plasma and tumour response and survival after preoperattive radiochemotherapy in patients with rectal cancer
Irena Oblak, Vaneja Velenik, Franc Anderluh, Barbara Možina, Janja Ocvirk, 2013, izvirni znanstveni članek

Povzetek: Background. The aim of this study was to analyse whether the level of tissue inhibitor of metalloproteinases (TIMP) 1 is associated with the tumour response and survival to preoperative radiochemotherapy in rectal cancer patients. Patients and methods. Ninety-two patients with histologically confirmed non-metastatic rectal cancer of clinical stage I- III were treated with preoperative radiochemotherapy, surgery and postoperative chemotherapy. Plasma TIMP-1 concentrations were measured prior to the start of the treatment with an enzyme-linked immunosorbent assay (ELISA). Results. Median follow-up time was 68 months (range: 3-93 months) while in survivors it was 80 months (range: 68-93 months). The 5-year locoregional control (LRC), disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) rates for all patients were 80.2%, 56.4%, 63.7% and 52.2%, respectively. The median TIMP-1 level was 185 ng/mL (range: 22-523 ng/mL) and the mean level (standard deviation) was 192 (87) ng/mL. Serum TIMP-1 levels were found to be significantly increased in patients with preoperative CRP>12 mg/L and in those who died from rectal cancer or had cT4 tumours. No correlation was established for age, gender, carcinoembriogenic antigene (CEA) level, platelets count, histopathological grade, response to preoperative therapy, resectability and disease reappearance. On univariate analysis, various parameters favourably influenced one or more survival endpoints: TIMP-1 <170 ng/mL, CRP <12 mg/L, platelets count <290 10E9/L, CEA <3.4mg/L, age <69 years, male gender, early stage disease (cN0 and/or cT2-3), radical surgery (R0) and response to preoperative radiochemotherapy. In multivariate model, LRC was favourably influenced by N-downstage, DFS by lower CRP and N-downstage, DSS by lower CRP and N-downstage and OS by lower TIMP-1 level, lower CRP and N-downstage. Conclusions. Although we did not find any association between pretreatment serum TIMP-1 levels and primary tumour response to preoperative radiochemotherapy in our cohort of patients with rectal cancer, TIMP-1 levels were recognized as an independent prognostic factor for OS in these patients.
Ključne besede: rectal cancer, radiochemotherapy, tissue inhibitor of metalloproteinases
Objavljeno v DiRROS: 22.03.2024; Ogledov: 37; Prenosov: 14
.pdf Celotno besedilo (370,87 KB)

2.
3.
Cetuximab in preoperative treatment of rectal cancer - term outcome of the XERT trial
Vaneja Velenik, Janja Ocvirk, Irena Oblak, Franc Anderluh, 2012, izvirni znanstveni članek

Povzetek: Preoperative capecitabine-based chemoradiotherapy (CRT) is feasible for the treatment of resectable locally advanced rectal cancer (LARC). To try to improve efficacy, we conducted a phase II studz in which the epidermal growth factor receptor-targeting monoclonal antibody cetuximab was added to capecitabine-based CRT. The results for long-term survival and for an analysis investigating the relationship between survival and patient and disease characteristics, including tumour KRAS mutation status, and surgery type, are presented. Patients with resectable LARC received capecitabine (1250mg/m2 twice daily, orally) for 2 weeks followed by cetuximab alone (400 mg/m2 for 1 week) and then with CRT (250 mg/m2/week) comprising capecitabine (825 mg/m2 twice daily) and radiotherapy to the small pelvis (45 Gz in 25 1.8-Gz fractions), five dazs a week for five weeks. Surgery was conducted six weeks following CRT, with post-operative chemotherapy with capecitabine (1250 mg/m2 twice daily for 14 days every 21 days) three weeks later. Forty-seven patients were enrolled and 37 underwent treatment. Twenty-eight of the patients (75.7%) had T3N+ disease. Thirty-six patients were evaluable for efficacy. The median follow-up time was 39.0 months (range 5.0-87.0). The three-year local control, disease-free survival, relapse-free survival and overall survival rates were 96.9% (95% CI 90.0-100), 72.2% (57.5-86.9), 74.3% (95% CI 59.8-88.8) and 68.1% (95% CI 36.7-99.4), respectively. There was no significant association between survival and gender, age, tumour location in the rectum, type of surgery, pathological T or N status, tumour regression grade or tumour KRAS mutation status, although sample sizes were small. Preoperative cetuximab plus capecitabine-based CRT was feasible in patients with resectable LARC and was associated with an impressive three-year local control rate. The use of tumour KRAS mutation status as a biomarker for the efficacy of cetuximab-based regimens in this setting requires further investigation.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 49; Prenosov: 18
.pdf Celotno besedilo (332,74 KB)

4.
Long term outcome after combined modality treatment for anal cancer
Irena Oblak, Primož Petrič, Franc Anderluh, Vaneja Velenik, Albert-Peter Fras, 2012, izvirni znanstveni članek

Povzetek: Background. The aim of the retrospective study was to evaluate the effectiveness and toxicity of radiochemotherapy in patients with squamous cellcarcinoma of the anal canal treated at a single institution. Patients and methods. Between 1/2003 and 9/2010, 84 patients were treated with radical radiochemotherapy at the Institute of Oncology Ljubljana, Slovenia. The treatment consisted of 3-dimensional conformal external beam radiotherapy with concurrent chemotherapy (5-fluorouracil and mytomycin C), followed by brachytherapy or external beam boost. The toxicity of therapy and its effectiveness were assessed. Results. The treatment was completed according tothe protocol in 79.8% of patients. The median follow-up time of 55 survivors was 53 months (range: 16-105 months). The 5-year locoregional control(LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates were 71%, 68%, 81%, 67% and 85%, respectively. No treatment-related mortality was observed. The most frequent acute side-effect of the treatment was radiodermatitis (grade 3-4 in 58.2% of patients). LENT-SOMA grade 3-4 late radiation side effects were observed in 15 (18%) patients. In patients with brachytherapy boost a trend of less late side effects was observed compared to patients with external beam boost (P=0.066). On multivariate analysis, complete clinicaldisease response was identified as an independent prognostic factor for LRC, DFS and DSS, the salvage surgery for LRC and DFS, whereas Hb below 120 g/l retained its independent prognostic value for OS. Conclusions. Radiochemotherapy provides an excellent disease control and the survival with preserving anal sphincter function in majority of patients. Surgical salvage with abdominoperineal resection for persistent or recurrent disease has curative potential.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 53; Prenosov: 22
.pdf Celotno besedilo (533,54 KB)

5.
6.
Rigidity of terminal simplices in persistent homology
Aleksandra Franc, Žiga Virk, 2023, izvirni znanstveni članek

Povzetek: Given a filtration function on a finite simplicial complex, stability theorem of persistent homology states that the corresponding barcode is continuous with respect to changes in the filtration function. However, due to the discrete setting of simplicial complexes, the simplices terminating matched bars cannot change continuously for arbitrary perturbations of filtration functions. In this paper we provide a sufficient condition for rigidity of a terminal simplex, i.e., a condition on $\varepsilon > 0$ implying that the terminal simplex of a homology class or a bar in persistent homology remains constant through $\varepsilon$-perturbations of filtration function. The condition for a homology class or a bar in dimension $n$ depends only on the barcodes in dimensions $n$ and $n+1$.
Ključne besede: persistent homology, stability theorem, terminal simplex, rigidity
Objavljeno v DiRROS: 15.03.2024; Ogledov: 55; Prenosov: 36
.pdf Celotno besedilo (476,36 KB)
Gradivo ima več datotek! Več...

7.
Proper holomorphic maps in Euclidean spaces avoiding unbounded convex sets
Barbara Drinovec-Drnovšek, Franc Forstnerič, 2023, izvirni znanstveni članek

Povzetek: We show that if $E$ is a closed convex set in $\mathbb C^n$, $n>1$ contained in a closed halfspace $H$ such that ▫$E\cap bH$▫ is nonempty and bounded, then the concave domain $\Omega=\mathbb C^n\setminus E$ contains images of proper holomorphicmaps $f : X \to \mathbb C^n$ from any Stein manifold $X$ of dimension $< n$, with approximation of a givenmap on closed compact subsets of $X$. If in addition $2 {\rm dim} X+1 \le n$ then $f$ can be chosen an embedding, and if $2 {\rm dim} X = n$, then it can be chosen an immersion. Under a stronger condition on $E$, we also obtain the interpolation property for such maps on closed complex subvarieties.
Ključne besede: Stein manifolds, holomorphic embeddings, Oka manifold, minimal surfaces, convexity
Objavljeno v DiRROS: 15.03.2024; Ogledov: 52; Prenosov: 33
.pdf Celotno besedilo (441,34 KB)
Gradivo ima več datotek! Več...

8.
9.
Recent developments on Oka manifolds
Franc Forstnerič, 2023, pregledni znanstveni članek

Povzetek: In this paper we present the main developments in Oka theory since the publication of my book "Stein Manifolds and Holomorphic Mappings (The Homotopy Principle in Complex Analysis)", 2nd ed., Springer, 2017. We also give several new results, examples and constructions of Oka domains in Euclidean and projective spaces. Furthermore, we show that for $n > 1$ the fibre $\mathbb C^n$ in a Stein family can degenerate to a non-Oka fibre, thereby answering a question of Takeo Ohsawa. Several open problems are discussed.
Ključne besede: Oka manifold, Oka map, Stein manifold, elliptic manifold, algebraically subelliptic manifold, Calabi–Yau manifold, density property
Objavljeno v DiRROS: 14.03.2024; Ogledov: 58; Prenosov: 32
.pdf Celotno besedilo (1014,41 KB)
Gradivo ima več datotek! Več...

10.
Minimal surfaces with symmetries
Franc Forstnerič, 2024, izvirni znanstveni članek

Povzetek: Let $G$ be a finite group acting on a connected open Riemann surface $X$ by holomorphic automorphisms and acting on a Euclidean space ${\mathbb R}^n$ $(n\ge 3)$ by orthogonal transformations. We identify a necessary and sufficient condition for the existence of a $G$-equivariant conformal minimal immersion $F:X\to{\mathbb R}^n$. We show in particular that such a map $F$ always exists if $G$ acts without fixed points on $X$. Furthermore, every finite group $G$ arises in this way for some open Riemann surface $X$ and $n=2|G|$. We obtain an analogous result for minimal surfaces having complete ends with finite total Gaussian curvature, and for discrete infinite groups acting on $X$ properly discontinuously and acting on ${\mathbb R}^n$ by rigid transformations.
Ključne besede: Riemann surfaces, minimal surfaces, G-equivariant conformal minimal immersion
Objavljeno v DiRROS: 13.03.2024; Ogledov: 58; Prenosov: 30
.pdf Celotno besedilo (483,34 KB)
Gradivo ima več datotek! Več...

Iskanje izvedeno v 0.31 sek.
Na vrh