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1.
A review of the treatment options for skin rash induced by EGFR-targeted therapies : evidence from randomized clinical trials and a meta-analysis
Janja Ocvirk, Steffen Heeger, Philip McCloud, Ralf-Dieter Hofheinz, 2013, izvirni znanstveni članek

Povzetek: Background. Agents targeting the epidermal growth factor receptor (EGFR) are amongst the most extensively used of the targeted agents in the therapy of some of the most common solid tumors. Although they avoid many of the classic side effects associated with cytotoxic chemotherapy, they are associated with unpleasant cutaneous toxicities which can affect treatment compliance and impinge on patient quality of life. To date, despite a plethora of consensus recommendations, expert opinions and reviews, there is a paucity of evidence-based guidance for the management of the skin rash that occurs in the treatment of patients receiving EGFR-targeted therapies. Methods. A literature search was conducted as a first step towards investigating not only an evidence-based approach to the management of skin rash, but also with a view to designing future randomized trials. Results. The literature search identified seven randomized trials and a meta-analysis was conducted using the data from four of these trials involving oral antibiotics. The meta-analysis of the data from these four trials suggests that prophylactic antibiotics might reduce the relative risk of severe rash associated with EGFR-targeted agents by 4277%. Vitamin K cream was also identified as having a potential role in the management EGFR-targeted agent induced rash. Conclusions. This review and meta-analysis clearly identify the need for further randomized studies of the role of oral antibiotics in this setting. The results of the ongoing randomized trials of the topical application of vitamin K cream plus or minus doxycycline and employing prophylactic versus reactive strategies are eagerly awaited.
Ključne besede: acne-like skin rash, cetuximab, erlotinib, gefitinib, panitumumab, vitamin K
Objavljeno v DiRROS: 22.03.2024; Ogledov: 27; Prenosov: 12
.pdf Celotno besedilo (403,77 KB)

2.
Assessing the generalizability of a performance predictive model
Ana Nikolikj, Gjorgjina Cenikj, Gordana Ispirova, Diederick Vermetten, Ryan Dieter Lang, Andries Petrus Engelbrecht, Carola Doerr, Peter Korošec, Tome Eftimov, 2023, objavljeni znanstveni prispevek na konferenci

Ključne besede: algorithms, predictive models, machine learning
Objavljeno v DiRROS: 15.09.2023; Ogledov: 271; Prenosov: 179
.pdf Celotno besedilo (935,67 KB)
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3.
Engineering aminoacyl-tRNA synthetases for use in synthetic biology
Natalie Krahn, Jeffery M. Tharp, Ana Crnković, Dieter Söll, 2020, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Objavljeno v DiRROS: 08.04.2022; Ogledov: 558; Prenosov: 173
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4.
Intein-based design expands diversity of selenocysteine reporters
Christina Z. Chung, Natalie Krahn, Ana Crnković, Dieter Söll, 2021, izvirni znanstveni članek

Objavljeno v DiRROS: 07.04.2022; Ogledov: 590; Prenosov: 396
.pdf Celotno besedilo (2,93 MB)
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Indirect routes to aminoacyl-tRNA : ǂthe ǂdiversity of prokaryotic cysteine encoding systems
Takahito Mukai, Kazuaki Amikura, Xian Fu, Dieter Söll, Ana Crnković, 2022, izvirni znanstveni članek

Objavljeno v DiRROS: 07.04.2022; Ogledov: 603; Prenosov: 466
.pdf Celotno besedilo (6,34 MB)
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7.
New data on lower Permian rugose corals from the Southern Karavanke Mountains (Slovenia)
Olga L. Kossovaya, Matevž Novak, Dieter Weyer, izvirni znanstveni članek

Povzetek: Studies of upper Palaeozoic corals from the Southern Alps (Karavanke Mountains in Slovenia and Carnic Alps along the Austrian/Italian border) started at the end of the 19th century. Since the mid-20th century, corals of the Karavanke Mountains have been studied in detail by several authors. Recently, several coral type localities and the coral groups occurring therein have been einvestigated. This paper deals in particular with the study of Carinthiaphyllum Heritsch, 1936 and all previously known data have been revised within this study. Most specimens of Carinthiaphyllum originate from museum collections and from new findings in the Dovžanova Soteska area of northern Slovenia. Additional material is represented by newly found samples from the locality of Mt. Boč in eastern Slovenia. The stratigraphic position and age of the Carinthiaphyllum occurrences are determined by fusulinid and conodont assemblages. Two species, Carinthiaphyllum crasseseptatum Gräf & Ramovš, 1965 and C. ramovsi n. sp., are described herein. New morphological features, including root-like protrusions and connecting stereoplasmic tubes, have been found for the first time in gregaria growth mode. Therefore, these new observations provide evidence of a solitary gregaria growth mode: individuals are invariably separated with contact and reciprocal support only by root-like, sometimes channeled tubes occurring as outgrowths of the archaeothecal wall. An emended diagnosis of Carinthiaphyllum is proposed herein. The studied collection is housed in the Museum für Naturkunde (Leibniz-Institut) at the Humboldt University in Berlin.
Ključne besede: Gregaria corals, Carinthiaphyllum, Asselian-Sakmarian, Southern Alps
Objavljeno v DiRROS: 04.03.2022; Ogledov: 579; Prenosov: 218
.pdf Celotno besedilo (7,42 MB)

8.
Quantification of the link between timed up-and-go test subtasks and contractile muscle properties
Andreas Ziegl, Dieter Hayn, Peter Kastner, Ester Fabiani, Boštjan Šimunič, Kerstin Löffler, Lisa Weidinger, Bianca Brix, Nandu Goswami, Günter Schreier, 2021, izvirni znanstveni članek

Povzetek: Frailty and falls are a major public health problem in older adults. Muscle weakness of the lower and upper extremities are risk factors for any, as well as recurrent falls including injuries and fractures. While the Timed Up-and-Go (TUG) test is often used to identify frail members and fallers, tensiomyography (TMG) can be used as a non-invasive tool to assess the function of skeletal muscles. In a clinical study, we evaluated the correlation between the TMG parameters of the skeletal muscle contraction of 23 elderly participants (22 f, age 86.74 % 7.88) and distance-based TUG test subtask times. TUG tests were recorded with an ultrasonic-based device. The sit-up and walking phases were significantly correlated to the contraction and delay time of the muscle vastus medialis (% = 0.55%0.80, p < 0.01). In addition, the delay time of the muscles vastus medialis (% = 0.45, p = 0.03) and gastrocnemius medialis (% = %0.44, p = 0.04) correlated to the sit-down phase. The maximal radial displacements of the biceps femoris showed significant correlations with the walk-forward times (% = %0.47, p = 0.021) and back (% = %0.43, p = 0.04). The association of TUG subtasks to muscle contractile parameters, therefore, could be utilized as a measure to improve the monitoring of elderly people%s physical ability in general and during rehabilitation after a fall in particular. TUG test subtask measurements may be used as a proxy to monitor muscle properties in rehabilitation after long hospital stays and injuries or for fall prevention.
Ključne besede: timed up-and-go test, tensiomyography, biomedical engineering, biomedical sensors, health
Objavljeno v DiRROS: 18.10.2021; Ogledov: 774; Prenosov: 690
.pdf Celotno besedilo (1,34 MB)
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9.
Versatility of synthetic tRNAs in genetic code expansion
Kyle S. Hoffman, Ana Crnković, Dieter Söll, 2018, pregledni znanstveni članek

Ključne besede: genetic code expansion, non-canonical amino acids, selenocysteine, synthetic biology, transfer RNA
Objavljeno v DiRROS: 07.05.2020; Ogledov: 1642; Prenosov: 1176
.pdf Celotno besedilo (1012,40 KB)
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