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Iskalni niz: "avtor" (Andrej Cör) .

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1.
Electrogene therapy with interleukin-12 in canine mast cell tumors
Darja Pavlin, Maja Čemažar, Andrej Cör, Gregor Serša, Azra Pogačnik, Nataša Tozon, 2011, izvirni znanstveni članek

Ključne besede: psi, tumor, zdravljenje, elektrogenska terapija, plazmidi
Objavljeno v DiRROS: 19.03.2024; Ogledov: 43; Prenosov: 13
.pdf Celotno besedilo (667,74 KB)

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Presence and role of Simian Virus 40 (SV40) in malignant pleural mesothelioma
Julija Hmeljak, Andrej Cör, 2009, pregledni znanstveni članek

Ključne besede: viral carcinogenesis, simian virus 40, mesothelioma, T antigen
Objavljeno v DiRROS: 08.03.2024; Ogledov: 71; Prenosov: 26
.pdf Celotno besedilo (427,91 KB)

4.
Detection of apoptotic cells in tumour paraffin sections
Jože Pižem, Andrej Cör, 2003, strokovni članek

Povzetek: Apoptosis is a distinct form of cell death characterised by specific morphological features and regulated by complex molecular mechanisms. Its deregulation is fundamental for tumour growth and progression and, moreover, anticancer therapies suppress tumour growth mainly by induction of apoptosis. Since the extent of apoptosis in a tumour may have prognostic as well as therapeutic implications, much effort has been invested in developing specificmethods that can be routinely used to detect apoptotic cells in archival formalin fixed paraffin-embedded tissue. Complex molecular pathways are involved in the regulation of apoptosis. Pro-apoptotic signals trigger activation of caspases that specifically cleave target proteins. Cleavage of proteins (caspase substrates) is responsible for morphological changes of apoptotic cells and DNA fragmentation. In the last decade, detection of apoptotic cells in formalin fixed tumour tissue sections has been based mainlyon morphology and characteristic DNA fragmentation. Recently, specific antibodies to activated caspases and cleaved target proteins (including cytokeratin 18, actin and PARP) have been produced that enable accurate detection of apoptosis in paraffin sections.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 115; Prenosov: 29
.pdf Celotno besedilo (170,01 KB)

5.
Survivin - an inhibitor of apoptosis and a new therapeutic target in cancer
Jože Pižem, Andrej Cör, 2003, strokovni članek

Povzetek: Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family. It inhibits apoptosis by interfering with post-mitochondrial events during apoptosis, thus blocking activation of caspases. The expression of survivin is among the most tumour specific of all human genes. It is overexpressed in most human cancers but is not detected in most normal tissues. Some molecular mechanisms of survivin upregulation in cancer have been elucidated, including loss of the wild-type p53. Tumours that overexpresssurvivin generally bear a worse prognosis and are associated with resistance to therapy. Its differential expression in caneer versus normal tissues makes survivin detection a useful tool in cancer diagnostics and a promising therapeutic target. Survivin targeting has resulted in increased spontaneous and induced apoptosis and inhibition of tumourgrowth. Some anticaneer drugs currently introduced into clinical practice might well act byinactivaring survivin.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 123; Prenosov: 27
.pdf Celotno besedilo (185,35 KB)

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The relationship between DNA methylation and expression of three different DNA methyltransferases in ovarian cancer
Andrej Cör, 2000, izvirni znanstveni članek

Povzetek: Background. DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis. The aim of the study was to ascertain the relationship between overall DNA methylation and the expression of DNMT1, DNMT3A and DNMT3B in ovarian cancer samples. Material and methods. DNA digestion with either methylation sensitive HpaII, or methylation insensitive MspI restriction endonuclease and quantitative reverse transcription-PCR methods were used to analyse global methylation levels and expression levels of five ovarian cancerand three normal ovarian tissue samples. Results. All five analysed cancer samples were hypomethylated. The differences of methylation levels between normal ovarian tissue and carcinoma samples were statistically significant (P<0.05). All five cancer samples showed overexpression of DNMT3A and DNMT3B, and only two ovarian tumour samples showed overexpression of DNMT1. There was no correlation between global demethylation and expression levels for the three different DNMTs.Conclusion. Genome wide hypomethylation facilitates tumor development with predisposition of cells to structural and numerical chromosomal aberrations but the paradox of the global hypomethylation observed in cancer cells and the high levels of DNMTs that arepresent in these cells still remain to be resolved.
Objavljeno v DiRROS: 25.01.2024; Ogledov: 142; Prenosov: 35
.pdf Celotno besedilo (322,13 KB)

8.
The role of thyroid radiation carcinogenesis in rats
Katarina Koritnik, Andrej Cör, 1998, izvirni znanstveni članek

Povzetek: The aimof this study was to test the hypothesis on the protective role of thyroxin administration before and during irradiation on the occurrence of thyroid carcinoma in rats. Application of thyroxin before and during irradiation was expected to decrease production of thyrotropin by the hypophyseal feedback mechanism, caused by radiation damage of thyroid tissue. Stabilizing the thyroid cells in this way during irradiation would thus make them less radiosensitive. In the experiment, we first divided 81 three to fourweek old Wistar strain rats of both sexes into two groups, i.e. thyroxin (T4) and water (H2O). The T4 rats were injected 1% thyroxin solution (0.01 mg/100 g body weight) twice a day for 15 days, while the H2O rats received saline in the same way. After ten days, the two main groups were divided each into two subgroups. The rats from both irradiated subgroups (T4/X and (H2O/X) recieved 10 Gy to the neck area. They were iradiated with a telecobalt machinefor five consecutive days with one direct field. During a two years follow - up, all moribund animals were sacrificed and their thyroid glands taken. The rest of the thyroid glands were taken at the end of the experiment.All glands were pathohistologically analysed. Besides, all suspicious and enlarged extrathyroid organs and tissues were examined and the occurrence of tumors was noted. Pathohistological examination revealed the occurrence of 8 thyroid carcinomas and 7 adenomas in the H2O/X group, and 3 adenomas in the T4/X group. In the iradiated group of rats without thyroxin, significantly (P = 0.01) more thyroid carcinomas occurred than in the irradiated group without thyroxin.
Objavljeno v DiRROS: 19.01.2024; Ogledov: 168; Prenosov: 39
.pdf Celotno besedilo (380,57 KB)

9.
Anatomija in histologija dojke
Raja Gošnak Dahmane, Andrej Cör, 2001, objavljeni znanstveni prispevek na konferenci

Povzetek: Dojki (mammae) sta parni kožni žlezi. Pri moškem ostaneta rudimentarni vse življenje, pri ženskah pa sta nerazviti pred puberteto, po puberteti rasteta in se diferencirata, najbolj sta razviti v zadnjih mesecih nosečnosti in med laktacijo ter usahneta po menopavzi. Dojka je zgrajena iz žleznega parenhima in vezivne strome ter interlobularnega maščobnega tkiva. Sestavlja jo 15 do 25lobusov. Vsak lobus predstavlja sestavljeno alveolarno žlezo z mlečnim izvodilom. Histološka slika dojke je drugačna v različnih starostnih obdobjih ženske, poleg tega pa se histološka slika spreminja pri ženskah v rodnem obdobju tudi med mesečnim ciklusom. Posebej pomembno za razumevanje zasevanja tumorjev je poznavanje limfne drenaže dojke.
Objavljeno v DiRROS: 30.11.2023; Ogledov: 225; Prenosov: 46
.pdf Celotno besedilo (1,20 MB)

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Razvoj in karakterizacija mišjega modela za študije HPV-pozitivnega raka glave in vratu
Živa Modic, Maja Čemažar, Boštjan Markelc, Andrej Cör, Gregor Serša, Simona Kranjc Brezar, Tanja Jesenko, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: miši, rak glave in vratu, gensko zdravljenje
Objavljeno v DiRROS: 19.06.2023; Ogledov: 337; Prenosov: 146
.pdf Celotno besedilo (361,47 KB)
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