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1.
Increased diversity of citrus tristeza virus in Europe
Jelena Zindović, Miroslav Čizmović, Ana Vučurović, Paolo Margaria, Dijana Škorić, 2023, izvirni znanstveni članek

Povzetek: This study investigated the genetic diversity of citrus tristeza virus (CTV) isolates from Montenegro and Croatia, European countries with the northernmost citrus growing regions situated on the Eastern Adriatic coast. Fifteen complete or nearly complete CTV genomes were reconstructed from high-throughput sequencing of samples collected in distinct municipalities in Montenegro and Opuzen municipality in Croatia. Phylogenetic analyses assigned some of the sequences to VT and T30 strains, previously recorded in Europe, while remarkably other isolates were placed in S1 and RB groups, which have not been reported in Europe so far. In addition, a new phylogenetic lineage including only isolates from Montenegro was delineated and tentatively proposed as the MNE cluster. Recombination analysis revealed evidence of 11 recombination events in the sequences obtained in this study, between isolates of related strains, within isolates of the same strain, and between distant strains. These findings show that CTV diversity in Europe is higher than reported before and calls for the re-evaluation of management strategies.
Ključne besede: complete genomes, genotyping, citrus tristeza virus, CTV, non-EU strain
Objavljeno v DiRROS: 29.03.2024; Ogledov: 0; Prenosov: 0
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2.
Modelling of traffic load effects in the assessment of existing road bridges
Dominik Skokandić, Ana Mandić Ivanković, Aleš Žnidarič, Mladen Srbić, 2019, pregledni znanstveni članek

Povzetek: Traffic load models used for the design of new bridges are based on conservative assumptions and have not been proven efficient for assessing safety of existing bridges. In the case of existing bridges, it is reasonable to use load models that are based on bridge weigh-in-motion data which, in addition to axle loads and spacing of bridge-crossing vehicles, provide information on bridge behaviour under traffic load. This paper provides an overview of traffic load models, as well as guidelines on the use of weigh-in-motion data when assessing condition of existing road bridges.
Ključne besede: prometna obtežba, tehtanje vozil med vožnjo, mostni WIM, ocenjevanje stanja, obstoječi mostovi, traffic load, weigh-in-motion, bridge WIM, condition assessment, existing bridges
Objavljeno v DiRROS: 27.03.2024; Ogledov: 28; Prenosov: 15
.pdf Celotno besedilo (687,33 KB)
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3.
Comparing algorithm selection approaches on black-box optimization problems
Ana Kostovska, Anja Janković, Diederick Vermetten, Sašo Džeroski, Tome Eftimov, 2023, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 25.03.2024; Ogledov: 29; Prenosov: 11
.pdf Celotno besedilo (582,18 KB)

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The prognostic and predictive value of human gastrointestinal microbiome and exosomal mRNA expression of PD-L1 and IFNγ for immune checkpoint inhibitors response in metastatic melanoma patients : protocol trial
Ana Erman, Marija Ignjatović, Katja Leskovšek, Simona Miceska, Urša Lampreht Tratar, Maša Omerzel, Veronika Kloboves-Prevodnik, Maja Čemažar, Lidija Kandolf Sekulović, Gorazd Avguštin, Janja Ocvirk, Tanja Mesti, 2023, izvirni znanstveni članek

Povzetek: Background: Immunotherapy has been successful in treating advanced melanoma, but a large proportion of patients do not respond to the treatment with immune checkpoint inhibitors (ICIs). Preclinical and small cohort studies suggest gastrointestinal microbiome composition and exosomal mRNA expression of PD-L1 and IFNγ from the primary tumor, stool and body fluids as potential biomarkers for response. Methods: Patients treated with immune checkpoint inhibitors as a first line treatment for metastatic melanoma are recruted to this prospective study. Stool samples are submitted before the start of treatment, at the 12th (+/−2) week and 28th (+/−2) week, and at the occurrence of event (suspected disease progression/hyperprogression, immune-related adverse event (irAE), deterioration). Peripheral venous blood samples are taken additionally at the same time points for cytologic and molecular tests. Histological material from the tumor tissue is obtained before the start of immunotherapy treatment. Primary objectives are to determine whether the human gastrointestinal microbiome (bacterial and viral) and the exosomal mRNA expression of PD-L1 and IFNγ and its dynamics predicts the response to treatment with PD-1 and CTLA-4 inhibitors and its association with the occurrence of irAE. The response is evaluated radiologically with imaging methods in accordance with the irRECIST criteria. Conclusions: This is the first study to combine and investigate multiple potential predictive and prognostic biomarkers and their dynamics in first line ICI in metastatic melanoma patients.
Ključne besede: gastrointestinal microbiome, mRNA expression of PD-L1 and IFNγ, immune checkpoint inhibitors, metastatic melanoma
Objavljeno v DiRROS: 21.03.2024; Ogledov: 56; Prenosov: 26
.pdf Celotno besedilo (642,09 KB)
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Trilinear embedding for divergence-form operators with complex coefficients
Andrea Carbonaro, Oliver Dragičević, Vjekoslav Kovač, Kristina Ana Škreb, 2023, izvirni znanstveni članek

Povzetek: We prove a dimension-free $L^p(\Omega)\times L^q(\Omega)\times L^r(\Omega)\rightarrow L^1(\Omega\times (0,\infty))$ embedding for triples of elliptic operators in divergence form with complex coefficients and subject to mixed boundary conditions on $\Omega$, and for triples of exponents $p,q,r \in (1,\infty)$ mutually related by the identity $1/p+1/q+1/r=1$. Here $\Omega$ is allowed to be an arbitrary open subset of $\mathbb{R}^d$. Our assumptions involving the exponents and coefficient matrices are expressed in terms of a condition known as $p$-ellipticity. The proof utilizes the method of Bellman functions and heat flows. As a corollary, we give applications to (i) paraproducts and (ii) square functions associated with the corresponding operator semigroups, moreover, we prove (iii) inequalities of Kato-Ponce type for elliptic operators with complex coefficients. All the above results are the first of their kind for elliptic divergence-form operators with complex coefficients on arbitrary open sets. Furthermore, the approach to (ii),(iii) through trilinear embeddings seems to be new.
Ključne besede: elliptic differential operator, p-ellipticity, operator semigroup, multilinear estimate
Objavljeno v DiRROS: 15.03.2024; Ogledov: 57; Prenosov: 35
.pdf Celotno besedilo (1,10 MB)
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9.
Reviewing the modeling aspects and practices of shallow geothermal energy systems
Paul Christodoulides, Ana Vieira, Stanislav Lenart, João Maranha, Gregor Vidmar, Rumen Popov, Aleksandar Georgiev, Lazaros Aresti, Georgios Florides, 2020, pregledni znanstveni članek

Povzetek: Shallow geothermal energy systems (SGES) may take different forms and have recently taken considerable attention due to energy geo-structures (EGS) resulting from the integration of heat exchange elements in geotechnical structures. Still, there is a lack of systematic design guidelines of SGES. Hence, in order to contribute towards that direction, the current study aims at reviewing the available SGES modeling options along with their various aspects and practices. This is done by first presenting the main analytical and numerical models and methods related to the thermal behavior of SGES. Then, the most important supplementary factors affecting such modeling are discussed. These include: (i) the boundary conditions, in the form of temperature variation or heat flow, that majorly affect the predicted thermal behavior of SGES; (ii) the spatial dimensions that may be crucial when relaxing the infinite length assumption for short heat exchangers such as energy piles (EP); (iii) the determination of SGES parameters that may need employing specific techniques to overcome practical difficulties; (iv) a short-term vs. long-term analysis depending on the thermal storage characteristics of GHE of different sizes; (v) the influence of groundwater that can have a moderating effect on fluid temperatures in both heating and cooling modes. Subsequently, thermo-mechanical interactions modeling issues are addressed that may be crucial in EGS that exhibit a dual functioning of heat exchangers and structural elements. Finally, a quite lengthy overview of the main software tools related to thermal and thermo-hydro-mechanical analysis of SGES that may be useful for practical applications is given. A unified software package incorporating all related features of all SGES may be a future aim.
Ključne besede: shalow geothermal energy systems, energy geo-structures, thermal analysis, thermo-hydro-mechanical, modelling, software tools
Objavljeno v DiRROS: 05.03.2024; Ogledov: 81; Prenosov: 37
.pdf Celotno besedilo (3,10 MB)
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