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1.
Modelling of traffic load effects in the assessment of existing road bridges
Dominik Skokandić, Ana Mandić Ivanković, Aleš Žnidarič, Mladen Srbić, 2019, pregledni znanstveni članek

Povzetek: Traffic load models used for the design of new bridges are based on conservative assumptions and have not been proven efficient for assessing safety of existing bridges. In the case of existing bridges, it is reasonable to use load models that are based on bridge weigh-in-motion data which, in addition to axle loads and spacing of bridge-crossing vehicles, provide information on bridge behaviour under traffic load. This paper provides an overview of traffic load models, as well as guidelines on the use of weigh-in-motion data when assessing condition of existing road bridges.
Ključne besede: prometna obtežba, tehtanje vozil med vožnjo, mostni WIM, ocenjevanje stanja, obstoječi mostovi, traffic load, weigh-in-motion, bridge WIM, condition assessment, existing bridges
Objavljeno v DiRROS: 27.03.2024; Ogledov: 27; Prenosov: 10
.pdf Celotno besedilo (687,33 KB)
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Oral treatment with etoposide in small cell lung cancer - dilemmas and solution
Renata Režonja, Lea Knez, Tanja Čufer, Aleš Mrhar, 2013, pregledni znanstveni članek

Povzetek: Background. Etoposide is a chemotherapeutic agent, widely used for the treatment of various malignancies, including small cell lung cancer (SCLC), an aggressive disease with poor prognosis. Oral etoposide administration exhibits advantages for the quality of life of the patient as well as economic benefits. However, widespread use of oral etoposide is limited by incomplete and variable bioavailability. Variability in bioavailability was observed both within and between patients. This suggests that some patients may experience suboptimal tumor cytotoxicity, whereas other patients may be atrisk for excess toxicity. Conclusions. The article highlights dilemmas as well as solutions regarding oral treatment with etoposide by presenting and analyzing relevant literature data. Numerous studies have shown that bioavailability of etoposide is influenced by genetic, physiological and environmental factors. Several strategies were explored to improve bioavailability and to reduce pharmacokinetic variability of oral etoposide, including desired and undesired drug interactions (e.g. with ketoconazole), development of suitable drug delivery systems, use of more water-soluble prodrug of etoposide, and influence on gastric emptying. In addition to genotype-based dose administration, etoposide is suitable for pharmacokinetically guided dosing, which enables dose adjustments in individual patient. Further, it is established that oral and intravenous schedules of etoposide in SCLC patients do not result in significant differences in treatment outcome, while results of toxicity are inconclusive. To conclude, the main message of the article is that better prediction of the pharmacokinetics of oral etoposide may encourage its wider use in routine clinical practice.
Ključne besede: oral etoposide, bioavailability, pharmacokinetic variability, small cell lung cancer, treatment
Objavljeno v DiRROS: 22.03.2024; Ogledov: 31; Prenosov: 7
.pdf Celotno besedilo (465,72 KB)

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Angiogenin and vascular endothelial growth factor expression in lungs of lung cancer patients
Aleš Rozman, Mira Šilar, Mitja Košnik, 2012, izvirni znanstveni članek

Povzetek: Background. Lung cancer is the leading cause of cancer deaths. Angiogenesis iscrucial process in cancer growth and progression. This prospective study evaluated expression of two central regulatory molecules: angiogenin and vascular endothelial growth factor (VEGF) in patients with lung cancer. Patients and methods. Clinical data, blood samples and broncho-alveolar lavage(BAL) from 23 patients with primary lung carcinoma were collected. BAL fluid was taken from part of the lung with malignancy, and from corresponding healthy side of the lung. VEGF and angiogenin concentrations were analysed by an enzyme-linked immunosorbent assay. Dilution of bronchial secretions in the BAL fluid was calculated from urea concentration ratio between serum and BAL fluid. Results. We found no statistical correlation between angiogenin concentrations in serum and in bronchial secretions from both parts of the lung. VEGF concentrations were greater in bronchial secretions in the affectedside of the lung than on healthy side. Both concentrations were greater than serum VEGF concentration. VEGF concentration in serum was in positive correlation with tumour size (p = 0,003) and with metastatic stage ofdisease (p = 0,041). There was correlation between VEGF and angiogenin concentrations in bronchial secretions from healthy side of the lung and between VEGF and angiogenin concentrations in bronchial secretions from part of the lung with malignancy. Conclusion. Angiogenin and VEGF concentrations insystemic, background and local samples of patients with lung cancer are affected by different mechanisms. Pro-angiogenic activity of lung cancer has an important influence on the levels of angiogenin and VEGF.
Objavljeno v DiRROS: 22.03.2024; Ogledov: 34; Prenosov: 17
.pdf Celotno besedilo (467,61 KB)

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Optimal approximation of spherical squares by tensor product quadratic Bézier patches
Aleš Vavpetič, Emil Žagar, 2023, izvirni znanstveni članek

Povzetek: In cited article E. F. Eisele considered the problem of the optimal approximation of symmetric surfaces by biquadratic Bézier patches. Unfortunately, the results therein are incorrect, which is shown in this paper by considering the optimal approximation of spherical squares. A detailed analysis and a numerical algorithm are given, providing the best approximant according to the (simplified) radial error, which differs from the one obtained mentioned article. The sphere is then approximated by the continuous spline of two and six tensor product quadratic Bézier patches. It is further shown that the $G^1$ smooth spline of six patches approximating the sphere exists, but it is not a good approximation. The problem of an approximation of spherical rectangles is also addressed and numerical examples indicate that several optimal approximants might exist in some cases, making the problem extremely difficult to handle. Finally, numerical examples are provided that confirm the theoretical results.
Ključne besede: Bézier patches, spherical squares, optimal approximation, sphere approximation
Objavljeno v DiRROS: 14.03.2024; Ogledov: 61; Prenosov: 32
.pdf Celotno besedilo (1,59 MB)
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Cryogenic transmission electron images of Phaeodactylum tricornutum isolates of small cellular particles
Apolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Veronika Kralj-Iglič, Anna Romolo, 2024, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.03.2024; Ogledov: 57; Prenosov: 41
.pdf Celotno besedilo (24,27 MB)
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Scanning electron microscope images of Phaeodactylum tricornutum culture
Apolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Veronika Kralj-Iglič, Anna Romolo, 2024, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.03.2024; Ogledov: 61; Prenosov: 45
.pdf Celotno besedilo (56,37 MB)
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Scanning electron microscope images of Dunaliella tertiolecta isolates of small cellular particles
Apolonija Bedina Zavec, Darja Božič, Matej Hočevar, Aleš Iglič, Marko Jeran, Anna Romolo, Veronika Kralj-Iglič, 2024, objavljeni znanstveni prispevek na konferenci

Objavljeno v DiRROS: 08.03.2024; Ogledov: 54; Prenosov: 25
.pdf Celotno besedilo (16,55 MB)
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