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Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery
Klemen Dovč, Charles Spanbauer, Eleonora Chiarle, Nataša Bratina, Elke Fröhlich-Reiterer, Nejka Potočnik, Dessi P. Zaharieva, Tim Hropot, Maria Fritsch, Peter Calhoun, Tadej Battelino, 2025, original scientific article

Abstract: Aims The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10–18 years) with type 1 diabetes. Materials and Methods We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70–140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC). Results The mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: −3.8 mg/dL; 95% confidence interval −5.8 to −1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0-mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin-to-carbohydrate ratios.Conclusions Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets.
Keywords: postprandial time in tight, range standard insulin aspart in youth with type 1, automated insulin delivery
Published in DiRROS: 03.12.2025; Views: 370; Downloads: 79
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Anxiety and COVID-19 anxiety in positive youth development : a latent profile analysis study
Tina Pivec, Ana Kozina, 2023, original scientific article

Keywords: anxiety, covid-19, covid-19 anxiety, positive youth development, PYD, analysis study
Published in DiRROS: 08.07.2025; Views: 456; Downloads: 231
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“Toeing the line” : The journal Grlica — caught between lofty socialist goals and quality music for young people
Boštjan Udovič, 2024, original scientific article

Abstract: This paper seeks to underscore the significance of Grlica as a pivotal journal for youth music in Slovenia from 1953 to 1988. It explores how Grlica played a crucial role in conveying the ideological and socio-political aspects of the socialist system prevalent during that period. Applying historical-developmental and historical-comparative methods, the paper presents three key findings. Firstly, Grlica was primarily a professional journal, with little to no ideological components. Secondly, the ones we do find were predominantly present in the initial period of Grlica’s publication, i.e., until 1965, becoming increasingly rare as time wore on. Thirdly, composers who published their works in Grlica held diverse ideological and musical orientations, indicating that Grlica was not only a professional journal but also characterised by broad-minded and open perspectives.
Keywords: journals for youth, journals, ideology, socialism, youth music
Published in DiRROS: 14.05.2025; Views: 507; Downloads: 279
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