1. Consequence of the introduction of routine FCH PET/CT imaging for patients with prostate cancer : a dual centre surveyMarina Hodolič, Laure Michaud, V. Huchet, S. Balogova, V. Nataf, K. Kerrou, M. Vereb, Jurij Fettich, Jean-Noël Talbot, 2014, original scientific article Abstract: Background. Fluorocholine(18F) (FCH) was introduced at the beginning of April 2010 in France, Slovenia and three other EU member states for the localisation of bone metastases of prostate cancer with PET. The aim of the study was to compare the evolution of diagnostic imaging in patients with prostate cancer using a new radiopharmaceutical FCH, observed in France and in Slovenia, and to quantify the consequence of the results of new imaging modality on the detection rate of abnormal metastases and recurrences of prostate cancer.Patients and methods. In two centres (France/Slovenia), a survey of the number of nuclear medicine examinations in patients with prostate cancer was performed, covering 5 quarters of the year since the introduction of FCH. For each examination, the clinical and biological circumstances were recorded, as well as the detection of bone or soft tissue foci.Results. Six hundred and eighty-eight nuclear medicine examinations were performed impatients with prostate cancer. Nuclear medicine examinations were performed for therapy monitoring and follow-up in 23% of cases. The number of FCH PET/CT grew rapidly between the 1st and 5th period of the observation (+220%), while the number of bone scintigraphies (BS) and fluoride(18F) PET/CTs decreased (-42% and -23% respectively). Fluorodeoxyglucose(18F) (FDG) PET/CT remained limited to few cases of castrate-resistant or metastatic prostate cancer in Paris. The proportion of negative results was significantly lower with FCH PET/CT (14%) than with BS (49%) or fluoride(18F) PET/CT (54%). For bone metastases, the detection rate was similar, but FCH PET/CT was performed on average at lower prostate-specific antigen (PSA) levels and was less frequently doubtful (4% vs. 28% for BS). FCH PET/CT also showed foci in prostatic bed (53% of cases) or in soft tissue (35% of cases).Conclusions. A rapid development of FCH PET/CT was observed in both centres and led to a higher detection rate of prostate cancer lesions.
Keywords: prostate cancer, PET/CT, fluorocholine (FCH), fluoride(18F), bone scintigraphy, indication of imaging, prostata, rak (medicina), slikovna diagnostika
Published in DiRROS: 04.04.2024; Views: 71; Downloads: 38
 Full text (595,04 KB)
This document has many files! More... |
2. |
3. |
4. |
5. |
6. Razvoj novih sistemskih zdravljenj pri bolnikih z razsejanim rakom prostateBoštjan Šeruga, Tomaž Milanez, Simona Borštnar, Nataša Snoj Šarvari, Breda Škrbinc, 2011, professional article Abstract: Hormonsko zdravljenje s kastracijo je v začetku navadno učinkovito pri večini bolnikov z razsejanim rakom prostate, vendar bolezen čez čas neizbežno napreduje. Docetaksel v kombinaciji s prednizonom predstavlja standardno zdravljenje v prvi liniji zdravljenja bolnikov z razsejanim, proti kastraciji odpornim rakom prostate (rKORP). Do danes je bilo v kliničnih raziskavah preizkušenih več učinkovin v kombinaciji z docetakselom, vendar se nobena kombinacija ni izkazala za učinkovitejšo od docetaksela samega. Za bolnike z rKORP, pri katerih bolezen napreduje po zdravljenju z docetakselom, predstavljata kabazitaksel in abirateron acetat novi možnosti sistemskega zdravljenja.
Keywords: prostata, rak (medicina), zdravljenje
Published in DiRROS: 31.08.2018; Views: 2906; Downloads: 774
Full text (157,10 KB) |
7. |
8. |
9. |
10. Natančno obsevanje lokalno napredovanega visokorizičnega raka prostateDaša Grabec, Uroš Gačnik, Borut Kragelj, 2011, professional article Abstract: Pri radioterapiji raka prostate je zelo pomembno oblikovati obsevalna polja tako, da se čim natančneje prilegajo volumnu, ki ga je treba obsevati. To pomeni, da moramo bolnika pri obsevanju čim natančneje nastaviti, saj s tem zmanjšamo potreben varnostni rob. Ob predpisani dozi na tarčni volumen bomo tako optimalno zaščitili kritične organe. Slikovno vodena radioterapija (IGRT) nam omogoča zmanjšanje varnostnega roba, ki zajema dnevna premikanja prostate. Ko z natančno nastavitvijo v marker upoštevamo translacijo prostate, moramo zajeti le še rotacijo prostate. Z analizo dnevnih rotacij prostate med frakcijami prvega dela radioterapije lahko varnostni rob okoli prostate optimiziramo. Njegovo optimalno velikost lahko uporabimo za drugi in tretji del radioterapije in prilagodimo obsevalni načrt (adaptivna radioterapija).
Keywords: prostata, neoplazme, rak (medicina), radioterapija
Published in DiRROS: 31.08.2018; Views: 2826; Downloads: 764
Full text (306,59 KB) |
