1. Spectrum of genetic variants and yield of genetic testing in Slovenian probands with suspected cardiomyopathies surviving sudden cardiac arrestNina Vodnjov, Aleš Maver, Borut Peterlin, Karin Writzl, 2025, original scientific article Abstract: Abstract Background Cardiomyopathies (CMs) present phenotypically on a spectrum and in a proportion of patients the initial presentation is sudden cardiac arrest (SCA). Studies performing genetic screening of SCA survivors have identifed (likely) pathogenic (LP/P) variants in 2–50% of probands, with mean cohort ages ranging from 28 to 64 years. Due to inconsistent data in the literature, our study aimed to genetically characterise Slovenian SCA survivors with clinically confrmed/suspected cardiomyopathy (CM). The present study included 29 probands (17 women, 59%) with clinically confrmed/suspected CM who survived SCA and were referred to the Clinical Institute of Genomic Medicine for genetic testing between January 2010 and July 2024. The majority of probands (23; 79%) underwent whole exome sequencing, and the remainder either clinical exome (5; 17%) or panel sequencing (1; 4%). Genetic data were analysed following ACMG/AMP guidelines and ACGS recommendations. Results Probands survived SCA at a mean age of 49±17 years (range 15–71), and 12 (41%) were<50 years old. The majority had clinically confrmed/suspected arrhythmogenic (10; 34.5%) or dilated (9; 31.0%) CM, while the remainder had clinically undefned (5; 17.2%), hypertrophic (4; 13.8%), or non-compaction (1; 3.4%) CM. Seven LP/P variants in CM-related genes were identifed in eight (28.6%) probands. In addition, 16 variants of uncertain signifcance (VUS) were identifed in 12 (41.3%) probands. Probands’ age at SCA did not signifcantly afect the yield, as LP/P variants were identifed in four probands<50 years at SCA and in four>50 years (p=0.56), nor did the positive family history of heart disease (p=0.55) or sudden cardiac death (p=0.43). There were also no signifcant diferences in probands’ age and test outcome, as the mean age of patients with LP/P variants was 46±21 years, those with the VUS(s) were 45±15 years, and those without candidate variant(s) were 55±12 years (p=0.41). Conclusions LP/P variants were identifed in almost one-third of Slovenian SCA survivors with clinically confrmed/ suspected CM. Genetic testing of SCA survivors with structural clinical fndings provides additional confrmation of the clinical diagnosis and a basis for identifying relatives at risk of heart disease, allowing for better management. Keywords: sudden cardiac arrest, genetic testing, molecular pathology, (likely) pathogenic variants, hereditary cardiomyopathy Published in DiRROS: 10.04.2026; Views: 232; Downloads: 131
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2. Fire performance of thin intumescent coatings : material characterisation and application to mass timber structuresFelix Wiesner, Andrea Lucherini, Wenxuan Wu, Cristian Maluk, Anwar Orabi, 2026, original scientific article Abstract: This study investigates the thermal behaviour of two opaque and one transparent thin intumescent coating at material level (coating only) and system level (coating applied at real scale on timber), and their effects on timber in fire. Micro-scale tests were conducted to examine the underlying mechanisms of intumescence and degradation for each coating individually, while bench-scale tests demonstrated how these behaviours translate to larger scales. Critical temperature and heat flux thresholds were identified at which the coatings begin to insulate the timber through the formation of the intumescent char layer, as well as those marking degradation of the layer and the reduction of its insulating efficacy. The findings highlight that coating type and thickness, heating conditions and exposure duration influence mass retention, swelling pattern, and the integrity of the intumescent char layer. Overall, the transparent coating exhibited lower durability than the opaque ones. It was also shown that, due to the similar temperature ranges of timber pyrolysis and coating swelling, timber degradation occurs close to the coated surface during the transient swelling process, resulting in a heated region of 15- 20 mm with negligible mechanical properties by the end of swelling. Therefore, intumescent coatings provide insulation progressively rather than immediately. Keywords: mass timber, thin intumescent coatings, swelling, fire testing, charring, fire safety Published in DiRROS: 08.04.2026; Views: 140; Downloads: 117
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4. Genetic testing for monogenic forms of male infertility contributes to the clinical diagnosis of men with severe idiopathic male infertilityRebeka Podgrajšek, Alenka Hodžić, Aleš Maver, Martin Štimpfel, Aleksander Andjelić, Olivera Miljanović, Momčilo Ristanović, Ivana Novaković, Dijana Plašeska Karanfilska, Predrag Noveski, Saša Ostojić, Borut Peterlin, 2025, original scientific article Abstract: In recent years, many genes have been associated with male infertility; however, testing of monogenic forms has not yet been clinically implemented in the diagnosis of severe forms of idiopathic male infertility, as the diagnostic utility has not been established yet. The aim of this study was therefore to answer if the implementation of genetic testing for monogenic forms of male infertility could contribute to the clinical diagnosis of men with severe forms of idiopathic male infertility. Materials and Methods: Based on the ClinGene curation protocol, we defined a panel of genes with sufficient evidence for the involvement with severe male infertility. We tested the 21-gene panel in a representative multicentric cohort of men with significantly impaired spermatogenesis. We performed whole exome sequencing on 191 infertile men with severe forms of idiopathic male infertility; non-obstructive azoospermia, and severe oligozoospermia (<5 million spermatozoa/mL). The control group consisted of 216 men who fathered a child. DNA was prepared based on the Twist CORE exome protocol and sequenced on the Illumina NovaSeq 6000 platform. Variants were classified using the Association for Clinical Genomic Science (ACGS) Best Practice Guidelines for Variant Classification in Rare Disease 2020. Results: We identified potential monogenic disease-causing variants in four infertile men. Pathogenic/likely pathogenic variants in STAG3 (c.2776C>T, p.Arg926*; c.2817delG, p.Leu940fs), MSH4 (c.1392delG, p.Ile465fs; c.2261C>T, p.Ser754Leu), TEX15 (c.6848_6849delGA, p.Arg2283fs; c.6271dupA, p.Arg2091fs), and TEX14 (c.1021C>T, p.Arg341*) genes were found. Conclusions: In the present multicentric cohort study, a monogenic cause in 2.1% of infertile men was identified. These findings confirm the utility of monogenic testing and suggest the clinical use of monogenic testing for men with severe forms of idiopathic male infertility. Keywords: azoospermia, genetic testing, male, meiosis Published in DiRROS: 18.03.2026; Views: 292; Downloads: 176
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5. 2F-3DPrint : D2.3 Structural analysis protocolLucija Hanžič, Luka Šadl, Rok Bregar, Miha Hren, 2026, project documentation (preliminary design, working design) Keywords: concrete, additive manufacturing, mechanical resistance, laboratory testing, Eurocode 6, TMS 402 Published in DiRROS: 16.03.2026; Views: 321; Downloads: 0 This document has many files! More... |
6. Engineering concept of the VNS - a beam-driven tokamak for component testingChristian Bachmann, M. Siccinio, E. Acampora, Aljaž Čufar, Irene Zammuto, 2025, original scientific article Abstract: The qualification of in-vessel components for a fusion power plant requires a test environment with a high flux of 14 MeV neutrons over a sufficiently large surface and volume. Performance testing and qualification of the complex design and technologies of fusion nuclear components is needed, in particular that of the tritium breeding blanket (BB). Testing in relevant conditions over a relevant time will also allow gaining the necessary confidence regarding the build-up and control of tritium inventories inside the BB, which will be an important radioactive source. An option of such a volumetric neutron source (VNS) is a beam-driven tokamak. A feasibility study of the main machine components and associated plant systems is described in this article. The machine has a major radius of 2.53 m, a single-null divertor configuration, and four tangential 120 keV beamlines that generate a fusion power of approximately 30 MW and provide current drive for a steady-state plasma scenario. The plasma is small with a minor radius of a = 0.55 m to maximize the neutron wall load, up to 0.5 MW/m², similar to what is targeted in ITER. Approximately 25 m² are available for blanket testing including 4 port plugs, which offer flexibility regarding the test module operating conditions and the implementation of instrumentation. Given the small plasma, much of the tokamak's volume is made up by the neutron shielding structures that are similarly sized as in ITER. To reduce the construction risk, ITER-like concepts were adopted for many components. In some cases, however, lessons learned from ITER led to the development of customized or innovative concepts. Due to the modest fusion power the plasma will burn <1 kg of tritium per year, which can be provided from external sources. Keywords: fusion reactors, volumetric neutron source, breeding blanket testing, tokamak, remote maintenance Published in DiRROS: 27.02.2026; Views: 359; Downloads: 199
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7. Force signal alignment in dynamic testing machine calibration applicationsMiha Hiti, 2026, original scientific article Abstract: Calibration of force in measuring systems where the force is time dependent i.e. dynamically changing, introduces additional complexities versus quasi-static calibration conditions. Time variable force signals necessitate accurate time alignment between concurrent signals – measurement series from unit under test and the measurement series from the reference standard need to be synchronised. Different unsynchronised measuring systems are typically used for acquisition of each calibration signal and they need to be time aligned in post- processing to eliminate as much as possible the influence of the sample misalignment from the resulting testing machine indication error. The paper focuses on the time synchronization of measurement series by using cross-correlation to determine the necessary time correction when calibrating testing machines with dynamic cyclic force excitation. Measurements are presented for calibration signals in the examples of 20 kN testing machine compression calibration for 5 kN ± 1 kN cycling force with 1 Hz, 5 Hz, and 10 Hz cycling frequencies, and 1000 kN testing machine tensile calibration for 500 kN ± 100 kN cycling force with 1 Hz cycling frequency. The standard deviation of the error distribution after time correction and clock rate compensation was below 0.2 % for both, 20 kN testing machine calibration, and 1000 kN testing machine calibration. Keywords: calibration, dynamic testing systems, time-synchronization, cross-correlation Published in DiRROS: 11.02.2026; Views: 537; Downloads: 230
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8. Development and field testing of a cavitation-based robotic platform for sustainable in-water hull cleaningUroš Puc, Andreja Abina, Edvin Salvi, Vlado Malačič, Janja Francé, Riccardo Zanelli, Aleksander Zidanšek, 2026, original scientific article Abstract: Biofouling on ship hulls significantly increases hydrodynamic drag, fuel consumption, and greenhouse gas emissions, while also facilitating the spread of invasive species in regional and global waters, thereby threatening marine biodiversity. To address these environmental and economic issues, we developed an innovative robotic platform for in-water hull cleaning. The platform utilizes a cavitation-based cleaning module that removes biofouling while minimizing hull surface damage and preventing the spread of detached particles into the marine environment. This paper describes the design, operation, and testing of a developed robotic cleaning system prototype. Emphasis is placed on integrating components and sensors for continuous monitoring of key seawater parameters (temperature, salinity, turbidity, dissolved oxygen, chlorophyll-a, etc.) before, during, and after underwater cleaning. Results from real-sea trials show the platform’s effectiveness in removing biofouling and its minimal environmental impact, confirming its potential as a sustainable solution for in-water hull cleaning. Keywords: biofouling, ship hulls, in-water cleaning, undewater robot, sensor integration, field testing Published in DiRROS: 27.01.2026; Views: 378; Downloads: 449
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9. DFOS-based monitoring of prestressed concrete bridge girders : preliminary resultsKleo Lila, Max Herbers, Bertram Richter, Andrea Agreiter, Maja Kreslin, Petra Triller, Andrej Anžlin, Werner Lienhart, Steffen Marx, 2025, published scientific conference contribution Abstract: Due to bridges’ critical role in transportation networks, the assessment and maintenance of existing bridges have become a priority. Prestressed concrete bridges constitute a significant portion of Europe’s transportation network, yet many no longer meet today’s technical requirements. This is primarily due to two factors: (i) the unforeseen increase in heavy goods traffic, and (ii) insufficient experience with early reinforced and prestressed concrete construction methods, coupled with inadequate regulations, which resulted in design weaknesses and structural deficiencies. One critical failure mechanism, identified when recalculating existing bridges based on updated guidelines, is insufficient shear load-bearing capacity, which has prompted the premature demolition of numerous bridges. A thorough understanding and rigorous monitoring of shear behavior is essential since neglecting this problem could lead to notable consequences, especially for aging infrastructure. In this paper, a distributed fiber optic sensor (DFOS) based monitoring system, inspired by shear detection concepts, is tested. A decommissioned prestressed concrete bridge girder was equipped with a DFOS grid, allowing for detailed monitoring of crack width, location, and shape. Preliminary test results confirm the successful installation and early detection of cracks, highlighting the system’s potential to identify microcrack formation, monitor crack growth, and support maintenance strategies. Keywords: structural health monitoring, distributed fiber optic sensors, microcracking, crack growths, load testing, prestressed concrete Published in DiRROS: 27.01.2026; Views: 380; Downloads: 218
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10. Laboratory testing of old bridge girders : preliminary resultsMaja Kreslin, Mirko Kosič, Aljoša Šajna, Andrej Anžlin, Doron Hekič, Vladimir Požonec, Petra Triller, 2025, published scientific conference contribution Abstract: This paper presents key results on the laboratory testing of old girders removed from a flood-damaged bridge located near Ljubljana, Slovenia. The structure was widened in 1989 to accommodate pedestrians and cyclists by integrating prefabricated prestressed reinforced concrete T-girders. To assess the structural behaviour of the bridge, six girders were subjected to a rigorous testing program involving bending and shear tests in a laboratory setting. The tests were performed on girders with static lengths of 12.20 meters and 9.90 meters. The program aimed to evaluate the structural performance of the girders. Preliminary results indicate satisfactory structural behaviour of the prestressed T-girders under the applied loads, with insights into their performance under both bending and shear stresses. This study contributes valuable data for assessing the long-term behaviour of bridges. The outcomes are particularly relevant for optimising resource allocation in bridge rehabilitation projects and ensuring safety and functionality in transportation networks. Keywords: laboratory testing, prestressed girders, assessment, load test, operational modal analysis, damage, acoustic emission Published in DiRROS: 22.01.2026; Views: 373; Downloads: 231
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