1. Repurposing medroxyprogesterone acetate and mefenamic acid for platinum-resistant ovarian cancerNika Marolt, Frederic Amant, Daniela Annibali, Tea Lanišnik-Rižner, 2025, published scientific conference contribution abstract Keywords: MPA, mefenamic acid, HGSOC, inhibition, AKRIC, ovarian cancer
Published in DiRROS: 18.03.2026; Views: 261; Downloads: 102
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4. The importance of chemical transformations of adsorbed molecules for corrosion inhibition : mercaptobenzimidazoles on copperAnton Kokalj, Erik Gregori, Barbara Kapun, Ingrid Milošev, 2025, original scientific article Abstract: This study investigates whether mercaptobenzimidazoles act as thiolates in inhibiting copper corrosion. To this end, we examined three mercaptobenzimidazole derivatives — 2-mercaptobenzimidazole (SH-BimH), 2-mercapto-1-methylbenzimidazole (SH-BimMe), and 2-(methylthio)benzimidazole (Me-S-BimH) — as corrosion inhibitors for copper in 3 wt% NaCl solution using a combined experimental and computational approach. Me-S-BimH has a thiol group (single bondSH) replaced by a methylthio group (single bondSCH ), which should prevent the formation of surface thiolates. In contrast, SH-BimMe has the same molecular formula as Me-S-BimH, but its methyl group does not cap the thiol group. Corrosion experiments reveal that after 1 h of immersion, Me-S-BimH is considerably less effective than SH-BimH and SH-BimMe at inhibiting copper corrosion. However, after 100 h of immersion, Me-S-BimH performs comparably to SH-BimH and SH-BimMe. This delayed effectiveness suggests that a molecular transformation activates Me-S-BimH over time. To explore this phenomenon, we performed a detailed DFT study of potential chemical transformations of adsorbed Me-S-BimH. Most transformations are exothermic, but only molecular deprotonation and Csingle bondS bond cleavage between the azole ring and the methylthio group exhibit sufficiently low activation barriers to occur at room temperature. Similar deprotonation and Csingle bondS bond cleavage reactions occur also for SH-BimH and SH-BimMe, leading to more strongly bound species than their intact molecular forms. Due to these transformations, Me-S-BimH and SH-BimH eventually result in the same strongly bound species, while SH-BimMe forms an analogous species. These findings may explain why, over time, all three compounds exhibit similar corrosion inhibition characteristics, and highlight the importance of chemical transformations of adsorbed molecules in corrosion inhibition.
Keywords: copper, corrosion inhibition, electrochemical measurements
Published in DiRROS: 25.08.2025; Views: 669; Downloads: 396
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5. “Paste test” – a method for evaluating the fungal inhibition potential of ground wood samplesEli Keržič, Miha Humar, 2025, original scientific article Abstract: As part of the »ULTRA – University of Ljubljana for a Sustainable Society« project, a new test method was introduced into the curriculum to provide insight into key properties that affect wood durability. This study aimed to adapt and verify the “paste test”, which uses wood dust in nutrient media to assess the inhibitory effect of wood components on fungal growth. The method was adapted to match the available laboratory equipment and simplified for educational use by students at the Department of Wood Science and Technology (Biotechnical Faculty, University of Ljubljana, Slovenia). The study involved testing fungal growth on nutrient media supplemented with spruce wood dust, with the goal of evaluating different grinding methods, nutrient media, and data analysis. Potato dextrose agar nutrient media was confirmed as a suitable alternative to malt extract agar. The wood dust fraction size had no significant effect on fungal inhibition, enabling the use of coarser, less time-saving grinding methods. Image analysis and logistic growth modelling were conducted using freely available software (ImageJ and R-Commander), which proved to be effective alternatives to proprietary tools. Visualization of growth using logistic growth rates offered a clearer comparative analysis, despite some loss of dynamic growth information.
Keywords: inhibition, wood chemistry, nutrient media, white rot fungi, brown rot fungi, logistic growth rate
Published in DiRROS: 15.07.2025; Views: 1003; Downloads: 543
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6. On the estimation of standard adsorption free energy from corrosion inhibition efficienciesAnton Kokalj, 2023, original scientific article Abstract: The standard adsorption Gibbs energy (Δ�−◦ ads) is often estimated by assuming that the corrosion inhibition efficiency is equivalent to fractional surface coverage. However, Lindsay et al. [Corros. Sci. 155 (2019) 182– 185] demonstrated that this assumption is not necessarily valid. Therefore, a model that maps inhibition efficiency to fractional surface coverage is developed herein to provide a more reliable estimation of Δ�−◦ ads. The model is validated with the experimental data of Lindsay et al.; the analysis confirms their conclusion that a significant error in Δ�−◦ ads estimation can be made by using inhibition efficiency as a proxy for surface coverage.
Keywords: standard adsorption free energy, corrosion inhibition, surface coverage, adsorption isotherm
Published in DiRROS: 29.04.2025; Views: 1043; Downloads: 473
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7. In situ, real-time imaging of redox-active species on Al/Cu galvanic couple and corrosion inhibition with 2-mercaptobenzimidazole and octylphosphonic acidDževad Kozlica, Brenda Hernández-Concepción, Javier Izquierdo Pérez, Ricardo M. Souto Suàrez, Ingrid Milošev, 2023, original scientific article Keywords: aluminum copper, scanning electrochemical microscopy, scanning vibrating electrode technique, oxygen reduction, neutral inhibition
Published in DiRROS: 23.04.2025; Views: 861; Downloads: 495
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8. On the use of the Langmuir and other adsorption isotherms in corrosion inhibitionAnton Kokalj, 2023, original scientific article Abstract: In corrosion inhibition studies, the standard adsorption Gibbs energy is often estimated via the linear regression of the Langmuir isotherm in the �∕� = 1∕� + � form, where both the intercept and the slope are estimated, although the Langmuir isotherm requires the slope of 1. Hence, �∕� = 1∕� +�� is actually used, where � is the slope. Herein, a theoretical basis for this equation is established. It is demonstrated to be an effective equation that can decently describe various adsorption models and provide relatively accurate estimates of the standard adsorption Gibbs energy, provided surface coverages are reliably determined experimentally. However, any significant deviation from the slope of 1 signals non-Langmuir adsorption due to inter-adsorbate interactions, multi-site adsorption, or surface heterogeneity. Among these three causes, only attractive inter-adsorbate interactions lead to a slope of less than 1.
Keywords: Langmuir isotherm, Flory–Huggins isotherm, Temkin isotherm, corrosion inhibition, standard adsorption free energy
Published in DiRROS: 23.04.2025; Views: 1260; Downloads: 358
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9. Considering the concept of synergism in corrosion inhibitionAnton Kokalj, 2023, original scientific article Abstract: Synergism in corrosion inhibition and how to best quantify it is explored conceptually. In the equation for the synergistic parameter, the mixture’s inhibition efficiency is evaluated against a threshold inhibition efficiency based on the performance of pure compounds. However, the choice for the threshold value is not unique. In the literature, the threshold of Aramaki–Hackerman is usually used. Herein, several other reasonable choices are developed, which are based on (i) the Langmuir adsorption model, (ii) the requirement that a mixture’s inhibition efficiency is higher than the highest inhibition efficiency of pure compounds, or (iii) that corrosion resistance in a mixture is higher than the sum of resistances in pure compounds. The presented synergistic models are also extended to multi-component mixtures.
Keywords: corrosion inhibition, synergism, Langmuir adsorption model
Published in DiRROS: 23.04.2025; Views: 863; Downloads: 281
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10. Corrosion inhibition of aluminium alloys by molybdate ions : a critical review of the chemistry, mechanisms and applicationsIngrid Milošev, 2024, review article Abstract: Molybdate anions are used as an individual inhibitor or in mixed synergistic combinations added directly to the solution, incorporated as fillers, pigments or nanocontainers into various coatings (sol-gel, anodised, plasma electrolytic, organic and layer double hydroxide coatings), as an agent in pre-treatments or post-treatments or as individual conversion coatings prepared to be exposed to aggressive media. The review addresses the action of molybdate on aluminium alloys in each of these applications. The general chemical characteristics of molybdenum are described with a particular emphasis on aqueous chemistry and the formation of monomer and polynuclear species.
Keywords: aluminium, molybdate, corrosion inhibition
Published in DiRROS: 17.04.2025; Views: 1193; Downloads: 770
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