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Abstract: Basal cell carcinoma (BCC) is a cutaneous malignancy that typically appears in sun-exposed areas. We analyzed data from the Insp-ECT registry of all patients affected by BCC in the head and neck region. The aim of this study was to evaluate the safety and efficacy of electrochemotherapy (ECT) on a 5-year basis. Patients and methods A cohort of 132 patients was included. They were treated by ECT according to the current Standard Operating Procedures. The median age was 74 years (range 41–93). There was a median of 1 nodule per patient (range 1–7), and the median size of the lesions was 1.4 cm (range 0.5–5.0 cm). Results Patients tolerated ECT well, and 96% agreed to repeat it if needed. The side effects were mild and temporary. All patients achieved a complete clinical response after 1 to 3 ECT sessions. During the first year of follow-up, 4 (3%) patients experienced recurrence, which was treated (2 with ECT, 1 with surgery, and 1 with a combination of ECT and surgery), after which they remained free of disease until the end of follow-up at 5 years. Five patients reported recurrence thereafter and were treated according to their condition. At the 5-year follow-up, the disease-free survival (DFS) rate was 92% (95% confidence interval [CI]: 87%–96%). At that time, 3 patients were alive with disease (2%), and 124 patients were free of disease (98%). Conclusions This study shows the feasibility and efficacy of ECT treatment in elderly patients with BCC tumors in aesthetically and functionally sensitive areas, with negligible toxicity. Comparable efficacy to other treatment modalities was demonstrated at 1 year and 5 years of follow-up in terms of DFS.
Keywords: basal cell carcinoma, electrochemotherapy, preživetje brez ponovitve bolezni
Published in DiRROS: 25.11.2025; Views: 297; Downloads: 98
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Abstract: Pomembnemu ugodnemu učinku zdravljenja z zaviralci imunskih nadzornih točk so relativno pogosto pridruženi neželeni zapleti, med katerimi so nevrološki redki, a lahko življenje ogrožujoči. V prispevku so predstavljeni nevrološki zapleti zdravljenja z zaviralci imunskih nadzornih točk. Podana klinična primera opišeta nevrološka zapleta s klinično sliko prizadetosti perifernega živčevja, in sicer miozitisom in akutno inflamatorno demielinizirajočo polinevropatijo.
Keywords: zaviralci imunskih nadzornih točk, toksičnost zdravil, imunske bolezni živčnega sistema
Published in DiRROS: 18.07.2025; Views: 497; Downloads: 148
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Keywords: rak (medicina), melanom, kožne bolezni, ultrazvočno sevanje, zaščita, preprečevanje bolezni
Published in DiRROS: 23.01.2025; Views: 583; Downloads: 234
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Keywords: krompir, zgodovina krompirja, krompirjevi škodljivci, krompirjeve bolezni, raziskave krompirja, Nacionalni inštitut za biologijo, sistemska biologija
Published in DiRROS: 02.12.2024; Views: 718; Downloads: 769
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Abstract: Cilja zdravljenja z obsevanjem benignih bolezni sta povrnitev funkcije in izboljšanje kakovosti življenja. Obsevanje benignih bolezni se običajno izvaja z nizko dnevno in celokupno obsevalno dozo. V primerjavi z dozo, ki se jo uporablja za zdravljenje malignih obolenj, je doza tukaj navadno precej nižja. S sodobnimi obsevalni-mi tehnikami, ki se uporabljajo v radioterapiji v zadnjem desetletju, je tveganje za poškodbe zdravega tkiva majhno. Z natančnim načrtovanjem obsevanja se žarki usmerijo na prizadeto območje, kar omogoča ohranitev zdravih tkiv. Obsevanje je tako varno in učinkovito, a je treba kljub temu vedno oceniti, kdaj je dobrobit obsevanja večja od morebitnih neželenih učinkov.
Keywords: obsevanje, benigne bolezni, bolečina
Published in DiRROS: 26.07.2024; Views: 1117; Downloads: 434
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