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Query: "keywords" (beta-lactamases) .

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1.
Biological activity of rat fibroblast interferon beta
1993, original scientific article

Abstract: The biological activity of rat fibroblast beta interferon was studied. Rat embryonal fibroblasts (Wistar strain-WiREF) were used as a source of interferon. Cells were grown in suspension and on the microcarries (Cytodex 3). In the exponential phase of cell growth the induction was performed. The biological activity of the obtained interferon was tested on the homologous cells. Interferon's influence on cell growth, morphology and intracellular level of some hydrolases was measured.
Keywords: fibroblasts-drug effects, interferon-beta, rats
Published in DiRROS: 10.01.2024; Views: 137; Downloads: 35
.pdf Full text (384,48 KB)

2.
Differences in ratio of carbon stable Isotopes among barley grain milling fractions with various concentrations of beta-glucans
Tom Levanič, Blaž Cigić, Mateja Germ, Ivana Polišenská, Kateřina Vaculová, Igor Pravst, Darja Kocjan Ačko, Ivan Kreft, 2023, original scientific article

Abstract: The grains of three barley varieties were milled and sieved to obtain respective milling fractions with a content of beta-glucans (b-G) from 1.4 to 10.7%. The enriched fraction obtained by the extraction and precipitation contained 24.7% of b-G. The differences between the ratio of stable C carbon isotopes were established. Milling fractions with coarse particles had more beta-glucans and a more negative ratio of δ 13C isotope in comparison to the respective intact barley grain. However, the enriched fraction had a less negative isotope ratio. So, it is not expected that the deviation from the stable isotope ratio of grain in milling fractions is the result of the content of b-G, but it depends on other barley grain constituents. In different parts of barley grain, there are substances with different stable isotope ratios, and by milling and sieving, they are assorted to the same milling fraction with most of the b-G. The method for determining the ratio of a stable carbon isotope in diverse barley grain fractions, applied in this investigation, is potentially opening the possibility for an additional method of screening the concentration of bioactive constituents in barley grain.
Keywords: beta-glucans, starch, barley, stable isotopes, nutrition, milling
Published in DiRROS: 02.08.2023; Views: 334; Downloads: 162
.pdf Full text (893,76 KB)
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3.
Brain dynamics underlying preserved cycling ability in patients with Parkinson’s disease and freezing of gait
Teja Ličen, Martin Rakuša, Nicolaas I. Bohnen, Paolo Manganotti, Uroš Marušič, 2022, review article

Abstract: Parkinson’s disease (PD) is generally associated with abnormally increased beta band oscillations in the cortico-basal ganglia loop during walking. PD patients with freezing of gait (FOG) exhibit a more distinct, prolonged narrow band of beta oscillations that are locked to the initiation of movement at ∼18 Hz. Upon initiation of cycling movements, this oscillation has been reported to be weaker and rather brief in duration. Due to the suppression of the overall beta band power during cycling and its continuous nature of the movement, cycling is considered to be less demanding for cortical networks compared to walking, including reduced need for sensorimotor processing, and thus unimpaired continuous cycling motion. Furthermore, cycling has been considered one of the most efficient non-pharmacological therapies with an influence on the subthalamic nucleus (STN) beta rhythms implicative of the deep brain stimulation effects. In the current review, we provide an overview of the currently available studies and discuss the underlying mechanism of preserved cycling ability in relation to the FOG in PD patients. The mechanisms are presented in detail using a graphical scheme comparing cortical oscillations during walking and cycling in PD.
Keywords: gait, freezing of gait, Parkinson's disease, cycling, cortical oscillations, beta band
Published in DiRROS: 21.06.2022; Views: 532; Downloads: 426
.pdf Full text (469,86 KB)
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4.
The effects of topical antibiotics on eradication and acquisition of third-generation cephalosporin and carbapenem-resistant Gram-negative bacteria in ICU patients : ǂa ǂpost hoc analysis from a multicentre cluster-randomized trial
Nienke L. Plantinga, Bastiaan H. Wittekamp, Christian Brun-Buisson, Marc J. M. Bonten, 2020, original scientific article

Abstract: Objectives: The aim was to quantify the effects of selective digestive tract decontamination (SDD) consisting of a mouth paste and gastro-enteral suspension, selective oropharyngeal decontamination with a mouth paste (SOD) and 1-2% chlorhexidine (CHX) mouthwash on eradication and acquisition of carriage of third-generation cephalosporin-resistant Enterobacterales (3GCR-E) and carbapenem-resistant Gram-negative bacteria (CR-GNB) in Intensive Care Unit (ICU) patients. Methods: This was a nested cohort study within a cluster-randomized cross-over trial in six European countries and 13 ICUs with 8665 patients. Eradication and acquisition during ICU stay of 3GCR-E and CRGNB were investigated separately in the rectum and respiratory tract for the three interventions and compared with standard care (SC) using Cox-regression competing events analyses. Results: Adjusted cause specific hazard ratios (CSHR) for eradication of rectal carriage for SDD were 1.76 (95% CI 1.31-2.36) for 3GCR-E and 3.17 (95% CI 1.60-6.29) for CR-GNB compared with SC. For the respiratory tract, adjusted CSHR for eradication of 3GCR-E were 1.47 (0.98-2.20) for SDD and 1.38 (0.92-2.06) for SOD compared with SC, and for eradication of CR-GNB these were 0.77 (0.41-1.45) for SDD and 0.81 (0.44-1.51) for SOD, compared with SC. Adjusted CSHRs for acquisition of rectal carriage during SDD (compared with SC) were 0.51 (0.40-0.64) for 3GCR-E and of 0.56 (0.40-0.78) for CR-GNB. Adjusted CSHRs for acquiring respiratory tract carriage with 3GCR-E compared with SC were 0.38 (0.28-0.50) for SDD and 0.55 (0.42-0.71) for SOD, and for CR-GNB 0.46 (0.33-0.64) during SDD and 0.60 (0.44-0.81) during SOD, respectively. SOD was not associated with eradication or acquisition of 3GCR-E and CR-GNB in the rectum. Conclusions: Among mechanically ventilated ICU patients, SDD was associated with more eradication and less acquisition of 3GCR-E and CR-GNB in the rectum than SC. SDD and SOD were associated with less acquisition of both 3GCR-E and CR-GNB than SC in the respiratory tract.
Keywords: intensive care units -- analysis -- epidemiology, bacterial drug resistance, anti-infective agents -- therapeutic use decontamination, beta-lactamases, Gram-negative bacteria, gastrointestinal tract -- microbiology -- drug therapy, cohort studies, colonization, ESBL, digestive tract
Published in DiRROS: 27.05.2022; Views: 496; Downloads: 198
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5.
Štiri posplošitve porazdelitve beta
Anton Cedilnik, 1993, original scientific article

Abstract: Porazdelitve, opisane v tem sestavku, imajo isti kompleksno analitični funkcijski izraz kot običajna porazdelitev beta, nosilci pa so omejeni, na eno stran omejeni ali neomejeni intervali. Te porazdelitve analiziramo, izračunamo momente, določimo racionalne transformacije in izpeljemo še nekaj limitnih izrekov.
Keywords: matematika, verjetnostni račun, porazdelitev beta, limitni izreki
Published in DiRROS: 12.07.2017; Views: 4185; Downloads: 1774
.pdf Full text (720,83 KB)

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