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The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer : results from the IDENTIFY study
Sinan Khadhouri, Kevin M Gallagher, Kenneth R. MacKenzie, Taimur T. Shah, Chuanyu Gao, 2025, original scientific article

Abstract: Objectives: To assess the contemporary malignancy rate in isolated de novo red patchesin the bladder and associated risk factors for better selection of red patch biopsy.Patients: Patients from the IDENTIFY dataset; Patients referred to secondary carewith suspected urinary tract cancer and found to have isolated de novo red patcheson cystoscopy.Methods: We reported the unadjusted cancer prevalence in isolated de novo redpatches that were biopsied; multivariable logistic regression was used to explorecancer-associated risk factors including age, sex, smoking, type of haematuria, LUTS,UTIs and a suspicious-looking red patch (as reported by the cystoscopist). Sub-analysis of these by clinical role and experience was performed.Results: A total of 1110 patients with isolated de novo red patches were included.41.5% (n = 461) were biopsied, with a malignancy rate of 12.8% (59/461), whichwas significantly higher in suspicious versus non-suspicious red patches (19.1%vs. 2.81%, p < 0.01). There was a significant association between bladder cancer andage (OR 1.04, 95% CI 1.01–1.07, p = 0.01), smoking history (OR 2.62, 95% CI 1.09–6.27, p = 0.03) and suspicious-looking patch (OR 6.50, 95% CI 2.47–17.1, p < 0.01).The majority of malignancies were in over 60-year-olds. Malignancy rates in suspicious versus non-suspicious red patches did not differ significantly betweenclinical roles or experiences.Limitations included subjectivity in classifying a suspicious patch and selection biasas not all patches were biopsied.Conclusions: Many patients still undergo unnecessary biopsies under general anaes-thetic for isolated de novo red patches. Clinicians should consider the patient’s age,smoking status and how suspicious-looking the patch is, before deciding on surveil-lance versus biopsy to improve cancer diagnostic yield.
Keywords: biopsy, bladder cancer, cystoscopy, haematuria, red patch, risk factors
Published in DiRROS: 09.04.2026; Views: 163; Downloads: 60
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Decoding polarity gradient enabled ultra-high lithium ion conduction
Yuqing Chen, Aiping Wang, Yun Zhao, Wei Wang, Robert Dominko, Peitao Xiao, Peng Gao, Yan Duan, Baohua Li, Xiangming He, Jilei Liu, 2026, original scientific article

Published in DiRROS: 10.03.2026; Views: 376; Downloads: 197
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New physics search at the CEPC : a general perspective
Xiaocong Ai, Stefan Antusch, Peter Athron, Miha Nemevšek, Xuai Zhuang, 2025, original scientific article

Abstract: The Circular Electron-Positron Collider (CEPC), a proposed next-generation Higgs factory, provides new opportunities to explore physics beyond the Standard Model (SM). With its clean electron-positron collision environment and the ability to collect large samples of Higgs, W, and Z bosons, the CEPC enables precision measurements and searches for new physics. This white paper outlines the CEPC's discovery potential, including studies of exotic decays of the Higgs, Z, and top quarks, dark matter and dark sector phenomena, long-lived particles, supersymmetry, and neutrino-related signatures. Advanced detector technologies and reconstruction techniques, such as one-to-one correspondence reconstruction and jet origin identification, significantly improve sensitivity to rare and weakly interacting processes. The CEPC is particularly well suited to probe the electroweak phase transition and test models of electroweak baryogenesis and dark sector interactions. In addition, global fit analyses highlight the CEPC's complementary role in constraining a wide range of new physics scenarios. These features position the CEPC as a powerful tool for exploring the next frontier in fundamental particle physics in the post-Higgs discovery era.
Keywords: collider, Standard Model, new physics
Published in DiRROS: 08.12.2025; Views: 1038; Downloads: 314
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