1. Učinek kombinacije elektrokemoterapije in anti-pd-1 imunoterapije pri mišjih modelih tumorjev z različnim imunskim statusomSimona Kranjc Brezar, Maša Omerzel, Urša Lampreht Tratar, Tanja Jesenko, Barbara Lisec, Gregor Serša, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, imunoterapija, elektrokemoterapija
Published in DiRROS: 18.03.2026; Views: 236; Downloads: 98
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2. Vzpostavitev elektroprenosa sistema transpomnožujočih mRNA na modelu mišjega melanoma B16-F10 in vitro in in vivoJaka Vrevc Žlajpah, Urška Kamenšek, Urša Lampreht Tratar, Maja Čemažar, Gregor Serša, Katja Uršič Valentinuzzi, 2025, published scientific conference contribution abstract Keywords: elektrokemoterapija, eksperimentalna onkologija, melanom
Published in DiRROS: 18.03.2026; Views: 165; Downloads: 59
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3. Recombinant cd30 nanobodies as robust and costeffective alternatives to conventional antibodies for diagnostics of hematologic malignanciesUrša Štrancar, Ario De Marco, Tim Božič, Živa Pišljar, Urša Lampreht Tratar, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: krvni raki, diagnostična dejavnost, onkologija
Published in DiRROS: 11.03.2026; Views: 167; Downloads: 70
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4. Genski elektroprenos mRNA z zapisom za IL-12 v celicah melanoma in kolorektalnega karcinomaAjda Medved, Urša Lampreht Tratar, Matjaž Peterka, Urban Bezeljak, Nastja Štemberger, Tjaša Marušič, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, genski elektroprenos, elektrokemoterapija
Published in DiRROS: 11.03.2026; Views: 173; Downloads: 63
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6. Genski elektroprenos reporterske mRNA v B16F10 in CT26 celični linijiAjda Medved, Urša Lampreht Tratar, Matjaž Peterka, Urban Bezeljak, Nastja Štemberger, Tjaša Marušič, Maja Čemažar, 2024, published scientific conference contribution abstract Keywords: elektroprenos genov, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 236; Downloads: 62
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7. Validacija nanoteles za vezavo na specifične antigene mukoznega melanoma (MM)Urša Lampreht Tratar, Ario De Marco, Urša Štrancar, Tim Božič, Barbara Perić, Maja Čemažar, 2024, published scientific conference contribution abstract Keywords: melanom, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 220; Downloads: 75
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9. Evaluation of methylene blue solution distribution in the four-point transversus abdominis plane block technique in pigs : a pilot anatomical studyJerneja Sredenšek, Jana Brankovič, Urša Lampreht Tratar, Maja Čemažar, Mihajlo Djokić, Alenka Seliškar, 2025, original scientific article Abstract: Aim: This prospective pilot anatomical study aimed to develop an ultrasoundguided transversus abdominis plane (TAP) block technique that desensitises cranial and mid-abdominal wall in grower pigs. We hypothesised that a fourpoint TAP approach would be more efficient than a three-point TAP in staining relevant nerves of the cranial and mid-abdominal wall. Methods: In phase I, the ultrasound anatomy of the abdominal wall musculature was examined on three pig cadavers (two piglets and one fattening pig) and the ultrasound localization of the needle in the corresponding interfascial plane was practised. In phase II, a three-point TAP injection was performed in three freshly euthanized cadavers of grower pigs. A 1% methylene blue solution (0.3 mL/ kg per injection point) was injected between the transversus abdominis and internal oblique muscle. In phase III, methylene blue solution was injected at four points (0.2 mL/kg per injection point) in four anaesthetized grower pigs prior to euthanasia. Positive nerve staining was defined as continuous staining of at least 1 cm of the nerve length. Binary variables (positive/negative) were used for nerve staining assessment. Results: The four-point TAP technique with a lower injection volume stained more nerves than the three-point technique with a higher injection volume, i.e., 69% of the observed nerves from the eighth-last thoracic to the third lumbar nerve were stained with the four-point TAP technique. The nerves in the centre were stained with a higher success rate, while the eighth-last thoracic and the second lumbar nerve were stained with less success (1/8 and 3/8, respectively). The third lumbar nerve was not stained. Conclusion: The four-point TAP technique could be used as part of a multimodal analgesia approach for cranial and mid-abdominal surgery in pigs, but live animal studies are needed to evaluate the clinical applicability and efficacy of desensitisation.
Keywords: abdominal surgery, cadaveric anatomical study, pig, regional anaesthesia, transversus abdominis plane block, methylene blue
Published in DiRROS: 09.12.2025; Views: 881; Downloads: 199
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10. Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivoAna Mitrović, Izidor Sosič, Špela Kos, Urša Lampreht Tratar, Barbara Breznik, Simona Kranjc Brezar, Bojana Mirković, Stanislav Gobec, Tamara Lah Turnšek, Maja Čemažar, Gregor Serša, Janko Kos, 2017, original scientific article Abstract: Lysosomal cysteine peptidase cathepsin B, involved in multiple processes associated with tumor progression, is validated as a target for anti-cancer therapy. Nitroxoline, a known antimicrobial agent, is a potent and selective inhibitor of cathepsin B, hence reducing tumor progression in vitro and in vivo. In order to further improve its anti-cancer properties we developed a number of derivatives using structure-based chemical synthesis. Of these, the 7-aminomethylated derivative (compound 17) exhibited significantly improved kinetic properties over nitroxoline, inhibiting cathepsin B endopeptidase activity selectively. In the present study, we have evaluated its anti-cancer properties. It was more effective than nitroxoline in reducing tumor cell invasion and migration, as determined in vitro on two-dimensional cell models and tumor spheroids, under either endpoint or real time conditions. Moreover, it exhibited improved action over nitroxoline in impairing tumor growth in vivo in LPB mouse fibrosarcoma tumors in C57Bl/6 mice. Taken together, the addition of a 2-(ethylamino)acetonitrile group to nitroxoline at position 7 significantly improves its pharmacological characteristics and its potential for use as an anti-cancer drug.
Keywords: nitroxoline derivative, cathepsin B, inhibition, tumor invasion, cell migration
Published in DiRROS: 26.07.2024; Views: 1174; Downloads: 845
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