1. Učinki obsevanja mišjih tumorjev na naučeno imunost in naravne celice ubijalkeTim Božič, Boštjan Markelc, Barbara Lisec, Iva Šantek, Simona Kranjc Brezar, Živa Pišljar, Tanja Jesenko, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, miši, celice ubijalke
Published in DiRROS: 11.03.2026; Views: 57; Downloads: 14
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2. Recombinant cd30 nanobodies as robust and costeffective alternatives to conventional antibodies for diagnostics of hematologic malignanciesUrša Štrancar, Ario De Marco, Tim Božič, Živa Pišljar, Urša Lampreht Tratar, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: krvni raki, diagnostična dejavnost, onkologija
Published in DiRROS: 11.03.2026; Views: 43; Downloads: 10
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5. Protitumorsko delovanje utišanja transkripcijskega faktorja E2F1 na modelu humanega kolorektalnega karcinoma : in vitro in in vivo spoznanjaSimona Kranjc Brezar, Tanja Jesenko, Monica Cazzato, Živa Pišljar, Boštjan Markelc, Tim Božič, Gabriele Grassi, Maja Čemažar, 2024, published scientific conference contribution abstract (invited lecture) Keywords: rak debelega črevesa in danke, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 154; Downloads: 24
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6. Validacija nanoteles za vezavo na specifične antigene mukoznega melanoma (MM)Urša Lampreht Tratar, Ario De Marco, Urša Štrancar, Tim Božič, Barbara Perić, Maja Čemažar, 2024, published scientific conference contribution abstract Keywords: melanom, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 127; Downloads: 25
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8. Chemokine CCL5 overexpression combined with radiotherapy modulates Th1-mediated immune response and leads to significant tumor growth delay in mouse tumor modelsTim Božič, Iva Šantek, Živa Pišljar, Simona Kranjc Brezar, Gregor Serša, Boštjan Markelc, Maja Čemažar, 2026, original scientific article Abstract: This study investigated the antitumor efficacy of chemokine CCL5 gene therapy using gene electrotransfer (GET) in combination with radiotherapy (RT) in solid murine tumors CT26 and 4T1. In vitro, CT26 and 4T1 tumor cells transfected with plasmid DNA (pDNA) encoding CCL5 induced migration of RAW264.7 macrophages. In vivo, CCL5 overexpression achieved via GET of pDNA encoding CCL5 led to increased splenocyte infiltration in dorsal window chamber models. When combined with RT, GET of pDNA encoding CCL5 shifted the tumor cytokine profile toward a proinflammatory state, with elevated Ifn-γ, Cxcl9, Cxcl10, and Il-12α. Although CD8 + and CD4 + T cells were reduced post-treatment, due to radiation-induced cell death, the combination of GET of pDNA encoding CCL5 and RT significantly delayed tumor growth in both models. In 4T1 tumors, this delay was also significant compared to the equivalent treatment with GET of control pDNA. These findings support GET of pDNA encoding CCL5 combined with RT as a strategy to enhance immune-mediated tumor control.
Keywords: chemokines, gene electrotransfer, gene therapy, mouse, radiotherapy
Published in DiRROS: 13.02.2026; Views: 347; Downloads: 47
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9. New mitochondrial ▫$K_V$▫1.3 conjugates are potent and specific inducers of apoptosis in cancer modelsŠpela Gubič, Marzia Fois, Ivan Džajić, Katja Kološa, Alja Štern, Maša Omerzel, Tim Božič, Boštjan Markelc, Tanja Jesenko, Maja Čemažar, Bojana Žegura, Tina Kosjek, Andrej Emanuel Cotman, Tihomir Tomašič, Lucija Peterlin-Mašič, 2026, original scientific article Keywords: mitochondrial targeting, mitochondrial KV1.3, apoptosis, cancer
Published in DiRROS: 12.02.2026; Views: 391; Downloads: 80
Full text (7,40 MB)
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