1. Additive and lithographic manufacturing of biomedical scaffold structures using a versatile thiol-ene photocurable resinMichael Kainz, Stjepan Perak, Gerald Stubauer, Sonja Kopp, Sebastian Kauscheder, Julia Hemetzberger, Adrián Martínez Cendrero, Andrés Díaz Lantada, Disha Tupe, Zoltan Major, Darja Marolt Presen, 2024, original scientific article Published in DiRROS: 20.03.2024; Views: 61; Downloads: 30 Full text (2,56 MB) This document has many files! More... |
2. Incidenca raka v prvem letu epidemije covida-19Vesna Zadnik, Tina Žagar, Nika Bric, Mojca Birk, Amela Duratović Konjević, Ana Mihor, Katarina Lokar, Sonja Tomšič, 2023, professional article Abstract: Uvod: Število novih diagnoz raka (incidenca) se v Sloveniji v zadnjem desetletju povečuje za povprečno 1,6 % na leto. V letu 2020, prvem letu omejitvenih ukrepov zaradi epidemije covida19, smo s platformo OnKOvid predvideli 3–8-odstotni padec novih diagnoz raka. Namen je predstaviti uradno incidenco raka za Slovenijo za leto 2020 in ugotoviti, kolikšen je bil dejansko manko novih diagnoz raka. Metode: V Registru raka Republike Slovenije smo v skladu z mednarodnimi pravili registrirali vse nove primere raka pri prebivalcih s stalnim prebivališčem v Sloveniji. Primerjali smo jih z registrirano incidenco za 2019, modelno incidenco za 2020, preliminarnimi rezultati OnKovida in dostopnimi rezultati incidence iz registrov raka iz drugih držav. Rezultati: V letu 2020 je za rakom zbolelo 15.096 oseb v Sloveniji (7.034 žensk, 8.002 moška). Glede na modelno oceno incidence za leto 2020 gre za manko 1.854 oseb (10,9 %; 11,6 % žensk, 10,4 % moških). Pri tem je za 10,5 % manj ugotovljenih rakov v omejenem stadiju, najbolj izrazito v starosti 50–69 let (za 13,2 %). Upad je primerljiv s poročili iz Anglije, ZDA in Kanade ter deloma večji kot na Škotskem in Švedskem. Najbolj izrazit upad novih diagnoz raka ugotavljamo pri nemelanomskem kožnem raku (23 %, najbolj po 50. letu), raku prostate (15,9 %, najbolj v omejenem stadiju), pljučnem raku (8,9 %, 60–64 let, v razširjenem stadiju), raku dojk (8,3 %, 45–64 let), ne-Hodgkinovem limfomu (9 %) in levkemijah (11,6 %). Pri kožnem melanomu, raku debelega črevesa in danke ni bilo primanjkljaja. Zaključek: Upad incidence raka v letu 2020 gre verjetno na račun omejitvenih ukrepov, reorganizacije zdravstva in z zdravjem povezanega vedenja med epidemijo covida-19, beležijo jo v več državah. Med epidemijami je potrebno nemoteno izvajanje onkologije. Keywords: rak, incidenca, register raka, epidemija, covid-19 Published in DiRROS: 26.02.2024; Views: 120; Downloads: 23 Full text (301,68 KB) |
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4. Bone marrow toxicity and antitumor action of adriamycin in relation to the antioxidant effects of melatoninValentina Rapozzi, Laura Perissin, Sonja Zorzet, Marina Comelli, Irene Mavelli, Marjeta Šentjurc, Alja Pregelj, Milan Valter Schara, Tullio Giraldi, 1998, original scientific article Published in DiRROS: 19.01.2024; Views: 128; Downloads: 35 Full text (1,73 MB) |
5. Impact assessment of the Gajke and Brstje landfills on groundwater status using stable and radioactive isotopesSonja Cerar, Luka Serianz, Polona Vreča, Marko Štrok, Tjaša Kanduč, 2023, original scientific article Abstract: Waste disposal in landfills represents a severe threat to aquatic environments on the local, regional, and global levels. In Slovenia, there are 69 registered landfills where groundwater is regularly monitored. However, isotope techniques are not regularly employed. Therefore, we employed isotope analysis of hydrogen, carbon, and oxygen in combination with total alkalinity to assess the impact of the selected landfill on groundwater and to evaluate the biogeochemical processes at work. The δ18O, δ2H, δ13CDIC, 3H activity and total alkalinity were determined in October 2020 at 12 sampling points from the surrounding area of the Gajke and Brstje landfills and leachate from the Gajke landfill. The δ18O (-9.24 ± 0.3 ‰) and δ2H (-64.9 ± 2.7 ‰) in groundwater indicate that the main water source consists in direct infiltration of precipitation, with no significant isotopic fractionation. Total alkalinity in the investigated area ranges from 5.45 to 73 mM and δ13CDIC from –14.9 to +6.1 ‰, respectively. Higher values of total alkalinity (up to 73 mM), δ13CDIC (up to +6.1 ‰), δ18O (-7.64 ‰) and 3H (209.8 TU) are detected in the leachate, indicating biogeochemical process related to CO2 reduction or methanogenesis. Methanogenesis could be present at locations GAP-10/13 (Brstje landfill) and G-2 (Gajke landfill) with δ13CDIC values ranging from –8.2 to –7.6 ‰ and with dissolved oxygen values around 0 % and elevated 3H values (from 16 to 18 TU). This study demonstrates the effectiveness of isotopic analysis as a valuable tool for monitoring landfills, revealing shifts in biogeochemical processes within the groundwater there. Keywords: groundwater, monitoring, landfill, stable isotopes, tritium, Gajke, Brstje Published in DiRROS: 16.01.2024; Views: 158; Downloads: 54 Full text (8,52 MB) |
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8. Advantages and disadvantages of hormone replacement therapySonja Bebar, Marjetka Uršič-Vrščaj, 1996, review article Abstract: In the developed countries, more than 30% of female population is in the postmenopusal period of their life. Approximately one third of these present with severe clinical menopausal symptoms, such as hot flushes, sleeplessness, night sweats, and depression. Many women search medical help. By means of hormone replacement therapy (HRT), these problems can be either completely eliminated or alleviated in 90% of women. The suspected association between HRT and risk of carcinoma should be ignored, however. While estrogens in combination with progestogens exert a protective effec against ovarian and endometrial carcinomas, a possible correlation between HRT and breast cancer has not been fully explained yet. Nevertheless, some published reports have indicated a slightly increased risk of breast cancer after a prolonged use of HRT. Published in DiRROS: 16.01.2024; Views: 117; Downloads: 32 Full text (229,66 KB) |
9. Natural porcine interferon gamma (PoIFN gamma)Bratko Filipič, Sonja Rozman, Katarina Carlsson, Avrelija Cencič, 1993, original scientific article Abstract: The natural porcine motogen induced gamma interferon (PoIFN gamma) was studied and compared with the human inerferons gamma (HuIFN gamma) and alpha (HuIFN alpha). A comparison was performed by the following criteria: pH 2.0 and 56 C stability, molecular weight, dot-blot reactions and cross reactivity (neutralisation index). The biological activity of porcine and human interferons in vitro (antiviral and antiproliferative) was correlated on humannontransformed (HEF) and transformed cells (FL). Keywords: interferon type II-analysis, cells, cultured-drug effects Published in DiRROS: 10.01.2024; Views: 126; Downloads: 35 Full text (335,59 KB) |
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