1. Green synthesis of a magnetite/graphitic carbon nitride 2D nanocomposite for efficient ▫$Hg^{2+}$▫ remediationRaghuraj S. Chouhan, Jan Gačnik, Igor Živković, Sreekanth Vijayakumaran Nair, Nigel Willy Van de Velde, Alenka Vesel, Primož Šket, Sonu Gandhi, Ivan Jerman, Milena Horvat, 2023, original scientific article Abstract: Novel nanoadsorbents demonstrate the potential to efficiently eliminate harmful substances, such as Hg2+, from the environment while preserving ecological balance. However, the search for environmentally-friendly nanomaterials as ideal adsorbents, as well as the development of suitable synthesis protocols, remains a challenge. This study presents an effective thermal-sonication technique for producing unique de novo tris-s-triazine carbon nitride nanosheets decorated with magnetite nanoparticles (M-g-CN). The structural integrity and chemical properties of the M-g-CN nanocomposite were extensively characterized using a battery of analytical instruments, including FTIR, SEM, TEM, XRD, XPS, AFM, Raman, and NMR. The obtained data, along with the analysis results, are discussed in detail. The novel synthesis method yields a high percentage (97.7%) of stable, highly selective, and reusable M-g-CN (40 mg mL−1). The resulting M-g-CN effectively binds Hg2+, with binding efficiencies of 96.0%, 97.5%, 98.2%, and 99.4% for Hg2+ concentrations of 50 pg mL−1 in marine, stream, precipitation, and ultra-pure matrices, respectively. Also, the magnetite-decorated particles can be easily retrieved using an applied magnetic field. This greener and scalable synthesis method does not require harsh chemicals, making it cost-effective, eco-friendly, and non-toxic compared to other technologies such as carbon filters, ion exchange resins, chemical precipitation, membrane filtration, electrochemical methods, and biological remediation. Overall, the synthesized M-g-CN exhibits wide-ranging potential applications, particularly as a green adsorbent in passive samplers or materials for remediation purposes.
Keywords: mercury, elimination, nanoadsorbents, nanocomposites
Published in DiRROS: 05.01.2026; Views: 84; Downloads: 33
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2. Glyoxal as single crosslinker for mechanically blown, condensed and hydrolyzable tannin foamsJonas Eckardt, Michele De Nato, Elena Colusso, Lorenzo Moro, Primož Šket, Samuele Giovando, Gianluca Tondi, 2025, original scientific article Published in DiRROS: 05.12.2025; Views: 202; Downloads: 84
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4. Thiol-reactive or redox-active : revising a repurposing screen led to a new invalidation pipeline and identified a true noncovalent inhibitor against papain-like protease from SARS-CoV-2Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, 2025, original scientific article Abstract: The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging. Comprehensive investigations utilizing enzymatic, binding studies, and cellular assays revealed the previously reported inhibitors to act in an unspecific manner. At present, GRL-0617 and its derivatives remain the best-validated compounds with demonstrated antiviral activity in cells and in mouse models. In this study, we refer to the pitfalls of the redox sensitivity of PLpro. Using a screening-based approach to identify inhibitors of PLpro’s proteolytic activity, we made extensive efforts to validate active compounds over a range of conditions and readouts, emphasizing the need for comprehensive orthogonal data when profiling putative PLpro inhibitors. The remaining active compound, CPI-169, was shown to be a noncovalent inhibitor capable of competing with GRL-0617 in NMR-based experiments, suggesting that it occupied a similar binding site and inhibited viral replication in Vero-E6 cells, opening new design opportunities for further development as antiviral agents.
Keywords: SARS-CoV-2, drug repurposing, papain-like protease, redox, STD-NMR, CPI-169, GRL-0617
Published in DiRROS: 20.08.2025; Views: 410; Downloads: 187
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5. Employing microalga Chlorella sorokiniana in the biosynthesis of paramagnetic and catalytically functional manganese clusterMarija Tanović, Milan Žižić, Milica Milenković, Zvonko Jagličić, Wilfred Hagen, Marina Stanić, Dalibor M. Stanković, Snežana Kovačević, Dmitry Karpov, Primož Šket, Uroš Javornik, Ivan Spasojević, Milena Dimitrijević, 2025, original scientific article Keywords: biosynthesis, manganese, microalgae
Published in DiRROS: 13.06.2025; Views: 536; Downloads: 288
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6. Deactivation of copper electrocatalysts during ▫$CO_2$▫ reduction occurs via dissolution and selective redeposition mechanismBlaž Tomc, Marjan Bele, Mohammed Azeezulla Nazrulla, Primož Šket, Matjaž Finšgar, Angelja Kjara Surca, Ana Rebeka Kamšek, Martin Šala, Jan Šiler Hudoklin, Matej Huš, Blaž Likozar, Nejc Hodnik, 2025, original scientific article Keywords: electrochemistry, catalysts, copper, hydrogen production
Published in DiRROS: 07.02.2025; Views: 794; Downloads: 404
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7. Synthesis of anti-inflammatory drugs’ chalcone derivatives and a study of their conformational properties through a combination of nuclear magnetic resonance spectroscopy and molecular modelingNikitas Georgiou, Andromachi Tzani, Kyriaki Vavougyiou, Christos Papadopoulos, Nikolaos Eleftheriadis, Primož Šket, Demeter Tzeli, Tuomas Niemi-Aro, Anastasia Detsi, Thomas Michael Mavromoustakos, 2025, original scientific article Published in DiRROS: 31.01.2025; Views: 603; Downloads: 400
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9. Towards a better understanding of biofoams : multi-technique characterization of various tannin-furanic foams to assist in material selection for product designThomas Sepperer, Giulia Saccomano, Diana E. Bedolla, Raphael J. F. Berger, Primož Šket, Elena Longo, Gregor A. Zickler, Saeed Borhani, Diego Dreossi, Lisa Vaccari, Maurizio E. Musso, Francesco D’Amico, 2024, original scientific article Published in DiRROS: 27.01.2025; Views: 592; Downloads: 383
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10. Role of isotropic lipid phase in the fusion of photosystem II membranesKinga Böde, Uroš Javornik, Ondřej Dlouhý, Ottó Zsiros, Avratanu Biswas, Ildikó Domonkos, Primož Šket, Václav Karlický, Bettina Ughy, Petar H. Lambrev, Vladimír Špunda, Janez Plavec, Győző Garab, 2024, original scientific article Published in DiRROS: 27.08.2024; Views: 993; Downloads: 623
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