Digital repository of Slovenian research organisations

Search the repository
A+ | A- | Help | SLO | ENG

Query: search in
search in
search in
search in

Options:
  Reset


Query: "author" (Peter Perdih) .

1 - 1 / 1
First pagePrevious page1Next pageLast page
1.
Post-polymerization modification of poly(L-glutamic acid) with d-(+)-glucosamine
Peter Perdih, Sašo Čebašek, Alenka Možir, Ema Žagar, 2014, original scientific article

Abstract: Carboxyl functional groups of poly(L-glutamic acid) (PGlu) were modified with a D-(+)-glucosamine (GlcN) by amidation using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4- methylmorpholinium chloride (DMTMM) as a coupling reagent. The coupling reaction was performed in aqueous medium without protection of hydroxyl functional groups of D-(+)-glucosamine. Poly(L-glutamic acid) and GlcN functionalized polyglutamates (P(Glu-GlcN)) were thoroughly characterized by 1D and 2D NMR spectroscopy and SEC-MALS to gain detailed information on their structure, composition and molar mass characteristics. The results reveal successful functionalization with GlcN through the amide bond and also to a minor extent through ester bond formation in position 1 of GlcN. In addition, a ratio between the α- and β-form of glucosamine substituent coupled to polyglutamate repeating units as well as the content of residual dimethoxy triazinyl active ester moiety in the samples were evaluated.
Keywords: poly(L-glutamic acid), glucosamine, glycopolypeptide
Published in DiRROS: 16.12.2014; Views: 4522; Downloads: 902
URL Link to full text

Search done in 0.03 sec.
Back to top