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Query: "author" (Nina Boc) .

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1.
MR staging karcinoma rektuma : kaj želi klinik izvedeti od radiologa
Anja Meden Boltežar, Nina Boc, 2022, published scientific conference contribution

Abstract: Pri bolnikih s karcinomom rektuma je v sklopu zamejitvenih preiskav glede na trenutne smernice potrebno opraviti MR preiskavo medenice. Pri tem je pomembna tako tehnična izvedba preiskave, kot tudi struktura samega izvida, ki ga pripravi radiolog. Ključni podatki, ki jih mora vsebovati izvid so: T in N status, oddaljenost od anokutane in anorektalne linije, podatek o infiltraciji analnega kompleksa, odnos tumorja glede na mezorektalno fascijo in podatek o ekstramuralni vaskularni invaziji. Za dobro izvedbo preiskave in pripravo izvida je ključna komunikacija med napotnim zdravnikom in radiologom. Podatki s katerimi želi radiolog razpolagati med pripravo izvida so: izvid digitorektalnega pregleda, izvid rektoskopije ali kolonoskopije z opisano globino na kateri leži tumorska formacija in patohistološki izvid tumorske formacije. Dobra komunikacija v smislu posredovanja izvidov vseh opravljenih preiskav in kliničnega statusa je še toliko bolj pomembna v sklopu sledenja po neoadjuvantnem zdravljenju, saj je le s slikovnimi preiskavami včasih težko ločiti med postterapevtskimi spremembami in ostankom tumorja.
Keywords: rak rektuma, sistemsko zdravljenje, rak prebavil
Published in DiRROS: 13.01.2023; Views: 84; Downloads: 18
.pdf Full text (96,17 KB)

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Transabdominalna ali transvaginalna UZ vodena biopsija mezenhimskih tumorejv maternice : pogled ginekologa in pogled radiologa
Jure Knez, Tadeja Skok, Nina Boc, 2022, published scientific conference contribution

Keywords: sarkomi, rak maternice, ginekološka onkologija, radiologija
Published in DiRROS: 16.11.2022; Views: 86; Downloads: 32
.pdf Full text (267,07 KB)
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BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome
Ana Blatnik, Domen Ribnikar, Vita Šetrajčič Dragoš, Srdjan Novaković, Vida Stegel, Biljana Grčar-Kuzmanov, Nina Boc, Barbara Perić, Petra Škerl, Gašper Klančar, Mateja Krajc, 2022, original scientific article

Abstract: BAP1 cancer syndrome is a rare and highly penetrant hereditary cancer predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) and cutaneous melanoma are considered BAP1 cancer syndrome core cancers, whereas association with breast cancer has previously been suggested but not confirmed so far. In view of BAP1 immunomodulatory functions, BAP1 alterations could prove useful as possible biomarkers of response to immunotherapy in patients with BAP1-associated cancers. We present a case of a patient with BAP1 cancer syndrome who developed a metastatic breast cancer with loss of BAP1 demonstrated on immunohistochemistry. She carried a germline BAP1 likely pathogenic variant (c.898_899delAG p.(Arg300Glyfs*6)). In addition, tumor tissue sequencing identified a concurrent somatic variant in BAP1 (partial deletion of exon 12) and a low tumor mutational burden. As her triple negative tumor was shown to be PD-L1 positive, the patient was treated with combination of atezolizumab and nab-paclitaxel. She had a complete and sustained response to immunotherapy even after discontinuation of nab-paclitaxel. This case strengthens the evidence for including breast cancer in the BAP1 cancer syndrome tumor spectrum with implications for future cancer prevention programs. It also indicates immune checkpoint inhibitors might prove to be an effective treatment for BAP1-deficient breast cancer.
Keywords: BAP1, breast cancer, hereditary cancer syndromes, immunotherapy
Published in DiRROS: 19.09.2022; Views: 132; Downloads: 62
.pdf Full text (1,12 MB)

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Radiološka ocena odgovora na stereotaktično obsevanje
Nina Boc, 2020, published professional conference contribution

Keywords: stereotaktično obsevanje, medicinska fizika, obsevalne tehnike
Published in DiRROS: 14.04.2022; Views: 264; Downloads: 116
.pdf Full text (518,84 KB)

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Prikaz primera: hipofizitis ob imunoterapiji metastatskega melanoma (MR značilnosti) : Elektronski vir
Tadeja Skok, Nina Boc, 2022, published scientific conference contribution

Keywords: melanom, rak kože, hipofizitis
Published in DiRROS: 11.04.2022; Views: 299; Downloads: 107
.pdf Full text (236,78 KB)

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Slikovne preiskave pri bolnikih z melanomom : Elektronski vir
Nina Boc, Tadeja Skok, 2022, published scientific conference contribution

Keywords: melanom, rak kože, radiologija
Published in DiRROS: 08.04.2022; Views: 314; Downloads: 109
.pdf Full text (309,93 KB)

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Vloga radiomike v napovedovanju učinkovitosti zdravljenja z imunoterapijo pri bolnikih z rakom pljuč
Martina Vrankar, Damijan Valentinuzzi, Nina Boc, Mojca Unk, 2021, published scientific conference contribution

Keywords: rak pljuč, radiomika, imunoterapija
Published in DiRROS: 04.04.2022; Views: 282; Downloads: 112
.pdf Full text (293,52 KB)

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