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Query: "author" (Matjaž Zwitter) .

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1.
Improved survival after introduction of chemotherapy for malignant pleural mesothelioma in Slovenia : population-based survey of 444 patients
Viljem Kovač, Matjaž Zwitter, Tina Žagar, 2012, original scientific article

Abstract: Background. Malignant pleural mesothelioma is a rare tumour with increasing frequency throughout the world. Due to long latency after exposure to asbestos, restrictions in the production and use of asbestos have not yet alleviated the burden of mesothelioma. During the last decade, several trials confirmed the benefit of systemic treatment with drugs such as doublets with cisplatina and gemcitabine or pemetrexed for carefully selected patients in good performance status. The purpose of this survey was to assess the impact of systemic treatment for the whole national population of patients with mesothelioma. Patients and methods. A retrospective study included all patients in Slovenia with histologically confirmed diagnosis of malignant pleural mesothelioma in the period from 1974 till 2008. Data from the Cancer Registry of Slovenia were supplemented by review of clinical records of the Institute of Oncology in Ljubljana where virtually all non-surgical treatment for mesothelioma was performed. We analysed the incidence, treatment, and survival of patients treated in the era of infrequent chemotherapy (1974-2003,the first period) and after it (2004-2008, the second period). Results. The survey included 444 patients, of whom 325 and 119 were diagnosed in the first and second period, respectively. Joinpoint regression analysis showed that after 1995 the trend in crude incidence rates increased more rapidly; the annual change was 0.03 per 100,000 per year before 1995 and 0.06 per 100,000 per year after. There was clear male predominance (70%) throughout the period covered by the survey. The proportion of patients above 65 years of age increased from 41.8% to 54.6% for the first and second period, respectively (p = 0.02). With a total of 52 (11.7%) operated patients, surgical treatment was rare and used only for selected patients with early disease and without comorbidity, leading to their relatively long median survival of 13.6 months. Chemotherapy was applied to 56 (17.2%) and to 96 (80.7%) patients during the first and second period, respectively. While a variety of older drugs were used in the first period, the most common regimen in the second period (applied to 91 patients) was doublet of low-dose gemcitabine in prolonged infusion and cisplatin. For the whole population of patients regardless the mode of treatment, median survival was 7.4 and 12.6 months (p-value = 0.037) for the first and second period, respectively. Conclusions. Increasing incidence, male predominance and increased proportion of older patients confirm that the burden of mesothelioma persists in spite o fa 15-years old ban in the production of asbestos. Modern chemotherapy, and in particular treatment with low-dose gemcitabine in prolonged infusion and cisplatin significantly prolonged median survival of patients with malignant pleural mesothelioma in Slovenia.
Published in DiRROS: 21.03.2024; Views: 57; Downloads: 21
.pdf Full text (588,42 KB)

2.
Brain metastases in lung cancer : impact of prognostic factors on patient survival
Uroš Smrdel, Matjaž Zwitter, Viljem Kovač, 2003, original scientific article

Abstract: Background. Brain metastases are common patterns of dissemination in lung cancer patients. In this paper we would like to assess the pattern of brain metastases in lung cancer patients and the impact of prognostic factors on thesurvival of lung cancer patients with brain metastases. Patients and methods. In the year 1998 there were 974 registered patients with lung cancer in Slovenia, six hundred and fifteen of them were treated at the Institute of Oncology Ljubljana and we analyzed them. Among 615 patients 137 (22.3%) of them have had brain metastases during a natural course of disease. Results. For 12 patients presenting with solitary brain metastases (most of them were undertaken metastaseetomy) median survival was 7.6 months, while in patients with multiple brain metastases the median survival was 2.8 months (p = 0.0018). Of the 137 patients 45 (32.8%) were small cell lung cancer patients, 43 (31.4%) were adenocarcinoma patients and 19 (13.9%) were squamous cell carcinoma patients. Patients with performance status (WHO scale) less than 2 had the median survival time 3.7 months while patients with performance status2 or more had median survival time 2.7 moths (p=0.0448). Conclusions. Patients with solitary brain metastases had better survival comparing with those who had multiple metastases. It is surprisingly that the portion of brain metastases patients with adenocarcinoma is almost equal to those with small-call lung cancer therefore, the prophylactic cranial radiation becomes actual for both groups of patients. The performance status of patients with brain metastases remains very important prognostic factor.
Published in DiRROS: 06.02.2024; Views: 118; Downloads: 33
.pdf Full text (98,88 KB)

3.
Ethical principles of autonomy and beneficence in genetic screening for breastcancer
Matjaž Zwitter, Tore Nilstun, Rastislav Golouh, 1996, review article

Published in DiRROS: 16.01.2024; Views: 115; Downloads: 36
.pdf Full text (308,03 KB)

4.
Introduction to ethical analysis
Matjaž Zwitter, Rastislav Golouh, 1996, review article

Published in DiRROS: 16.01.2024; Views: 134; Downloads: 40
.pdf Full text (250,65 KB)

5.
Cyclosporine A for the treatment of hodkin,s disease in relapse after extensive chemotherapy
Matjaž Zwitter, Jože Drinovec, J. Vodnik-Cerar, Žarka Žemva, 1985, original scientific article

Keywords: Hodkinova bolezen
Published in DiRROS: 14.09.2023; Views: 324; Downloads: 68
.pdf Full text (501,33 KB)

6.
Obsevanje vsega telesa pri bolnikih z anaplastičnim mikrocelularnim karcinomom bronhija
Matjaž Zwitter, Berta Jereb, 1977, original scientific article

Keywords: karcinom bronhija, obsevanje, radioterapija
Published in DiRROS: 14.09.2023; Views: 243; Downloads: 70
.pdf Full text (732,96 KB)

7.
O doktrinah in o individualnem odločanju
Matjaž Zwitter, 1999, published scientific conference contribution abstract

Published in DiRROS: 07.07.2021; Views: 785; Downloads: 246
.pdf Full text (578,64 KB)

8.
Smernice za ne-kirurško zdravljenje bolnikov z rakom pljuč
Matjaž Zwitter, Marija-Marjeta Plaper-Vernik, Viljem Kovač, Miha Debevec, 1997, dictionary, encyclopaedia, lexicon, manual, atlas, map

Published in DiRROS: 10.05.2021; Views: 1063; Downloads: 390
.pdf Full text (744,57 KB)

9.
Advanced course on ethics in oncology : programme and course material, June 25 - 28, 2000, Bled, Slovenia
2000, professional monograph

Published in DiRROS: 29.04.2021; Views: 1144; Downloads: 354
.pdf Full text (8,40 MB)

10.
Smernice za ne-kirurško zdravljenje bolnikov z rakom pljuč
Matjaž Zwitter, Viljem Kovač, Marija-Marjeta Plaper-Vernik, dictionary, encyclopaedia, lexicon, manual, atlas, map

Published in DiRROS: 09.04.2021; Views: 887; Downloads: 355
.pdf Full text (602,92 KB)

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