1. Priporočila za obravnavo bolnic z rakom jajčnikov, jajcevodov in s primarnim peritonealnim seroznim rakom v SlovenijiNina Kovačević, Barbara Šegedin, Sebastjan Merlo, Sonja Bebar, Ana Blatnik, Andrej Cokan, Branko Cvjetičanin, Nina Fokter Dovnik, Barbara Gazić, Biljana Grčar-Kuzmanov, Brigita Gregorič, Matej Horvat, Vid Janša, Jure Knez, Borut Kobal, Manja Šešek, Mateja Krajc, Maja Krajec, Mateja Lasič Pecev, Srdjan Novaković, Maja Pakiž, Maja Ravnik, Špela Smrkolj, Ksenija Strojnik, Erik Škof, Iztok Takač, Gregor Vivod, Vesna Zadnik, Helena Barbara Zobec Logar, 2022, professional article Keywords: rak (medicina), ginekološki raki, ginekologija, onkologija, epidemiologija, histopatologija, preživetje, diagnostika, zdravljenje, kirurgija
Published in DiRROS: 22.01.2026; Views: 348; Downloads: 234
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2. Dnevnik bolnika, ki prejema zdravilo nab-paklitaksel : urednica Janja OcvirkMaja Ravnik-Oblak, Matej Horvat, 2017, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak dojke, kemoterapija, nab-paklitaksel
Published in DiRROS: 02.09.2025; Views: 564; Downloads: 220
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3. Microsatellite instability in colorectal cancerMatej Horvat, Borut Štabuc, 2011, review article Abstract: Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequenceof inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) arerepeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
Published in DiRROS: 19.03.2024; Views: 1433; Downloads: 653
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4. Progresivna multifokalna levkoencefalopatija po rituksimabu pri bolniku z recidivnim limfomom plaščnih celic v popolni remisijiTanja Roš-Opaškar, Matej Horvat, Mara Popović, Barbara Jezeršek Novaković, 2012, original scientific article Abstract: Progresivna multifokalna levkoencefalopatija (PML) je redko in običajno smrtno demielinizacijsko obolenje možganov, ki se razvije skoraj izključno pri bolnikih z imunsko pomanjkljivostjo in je posledica reaktivacije latentne okužbe s polioma virusom JC. V zadnjih letih so opisani tudi primeri PML po zdravljenju z rituksimabom. Predstavljamo naš prvi potrjeni primer PML pri 55-letnem HIV-negativnem bolniku z recidivnim limfomom plaščnih celic, pri katerem smo raka uspešno zdravili s kemoterapijo in rituksimabom ter z avtologno presaditvijo perifernih krvotvornih matičnih celic (PKMC). S primerom želimo opozoriti na pomembnost PML v diferencialni diagnozi pri bolnikih z napredujočo nevrološko simptomatiko in imunsko pomanjkljivostjo po zdravljenju limfoma z rituksimabom ter pomembnost zgodnjega prepoznavanja te bolezni z dokazom JC-virusne okužbe v likvorju ali v vzorcu stereotaktične biopsije možganov.
Published in DiRROS: 31.08.2018; Views: 5664; Downloads: 1336
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