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Query: "author" (Lojze %C5%BDgajnar) .

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1.
Cysteine proteinase inhibitors stefin A and stefin B in operable carcinoma of the head and neck : Inhibitorji cisteinskih proteinaz stefin A in stefin B pri operabilnem karcinomu glave in vratu
Primož Strojan, Marjan Budihna, Alojz Šmid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez Škrk, 2002, original scientific article

Abstract: Purpose. To evaluate the significance of cysteine proteinase inhibitors stefins (Stefs) A and B for a treatment decision and prognosis in operable squamous cell carcinoma of the head and neck (SCCHN). Patients and methods. Stefs A and B concentrations were determined immunobiochemically using ELISAs in cytosols prepared from the tumor and adjacent normal mucosa from 91 patients with operable SCCHN. The median follow-up period of patients alive atthe close-out date was 5.8 years (range, 5-9.3 years). Results. Stef A concentrations were significantly higher in tumor compared to normal mucosa (FM.05). When a subgroup with clinically palpable nodes) at presentation was taken into consideration (n=57), a significant difference in Stef A (P=0.03) and Stef B (P=0.02) concentrations between those with negative and positive necks, as determined on histopathological examination, was observed. On the univariate survival analysis, higher Stefsć concentrations turned to be prognostically advantageous. Stef A proved its independent prognostic significance also on multivariate setting. Conclusions. With the capability todifferentiate between the pN0- and pN+-stages of the disease in the patientsoriginally presented as node-positive, Stefs A and B could be useful markers when deciding on the extent of neck surgery. In addition, both Stefs proved to be reliable prognosticators for survival in patients with operable SCCHN.
Published in DiRROS: 31.01.2024; Views: 118; Downloads: 29
.pdf Full text (114,91 KB)

2.
Factors influencing rehabilitation in patients with head and neck cancer
Irena Hočevar-Boltežar, Alojz Šmid, Miha Žargi, Avgust Župevc, Igor Fajdiga, Janez Fischinger, Ana Jarc, 2000, original scientific article

Abstract: Purpose. The purpose of the prospective study was to identify the factors adversely influencing the post-treatment rehabilitation in patients with head and neck cancer. Patients and methods. One hundred and ten patients with oral cavity, pharyngeal and laryngeal cancer were examined before surgical treatment in order to find unfavorable factors: hearing loss, defective teeth,impaired pulmonary function, and speech disorders. The patients evaluated the success of their rehabilitation 12 months after the treatment. The influence of possible unfavorable factors, tumor site, and type of surgeryon speech, swallowing and reintegration competence was determinated. Results. The site of the tumor and the type of surgery did not influence the quality of rehabilitation in general. Defective teeth influenced the ability of swallowing but not the speech. Hearing loss impaired the patient's reintegration in their home environment. Impaired pulmonary function did not affect patient's speech. Speech was the poorest in laryngectomized patients. However, about two thirds of the patients were satisfied with their capabilityof speech, swallowing and their rehabilitation in general. Conclusions. Early identification of unfavorable factors, and individually planned rehabilitation can ensure a suitable quality of life for patients thathave undergone surgery for head and neck cancer.
Published in DiRROS: 25.01.2024; Views: 119; Downloads: 36
.pdf Full text (322,91 KB)

3.
Ultrasound-guided aspiration biopsy of subclinical regional metastases of head and neck carcinoma
Alenka Višnar-Perovič, Aleksandar Aničin, Živa Zupančič, Bojana Černelč, Alojz Šmid, Dubravka Vidmar, Milan Gorenc, 2000, original scientific article

Abstract: Background. Studies concerned with the estimation of ultrasound (US) combined with ultrasound-guided aspiration biopsy (USGAB) in the detection of subclinical regional metastases from the planocellular carcinoma of head and neck are promising, but in few cases. Recently, the authors have pointed out the role of lymph node size parameters in order to decide about the use of USGAB. The aim of this study was to test the reliability of US-USGAB for the detection of subclinical regional metastases in patients with planocellular head and neck carcinomas, including the evaluation of lymph node size parameters. Patients and methods. 121 neck sides with no palpable metastases were examined by US in 77 patients with planocellular carcinomas of head and neck. Depending on the results obtained, USGAB was performed on 64 neck sides.After surgery, the results of US-USGAB were compared with histological findings of the dissected lymph nodes. Results. The study showed 77% overall sensitivity of US and USGAB, and 100% specificity, while the versal / longiyudinal diameter was the best predictor of metastatic lymph node involvement. Conclusion. The results of this study established that USGAB is an appropriate method for detection the subclinical regional metastases on neck, and should be included into routine diagnostic work up in the evaluationof the extent of head and necks carcinomas.
Published in DiRROS: 24.01.2024; Views: 140; Downloads: 32
.pdf Full text (415,17 KB)

4.
Cathepsin H in squamous cell carcinoma of the head and neck
Primož Strojan, Marjan Budihna, Alojz Šmid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez Škrk, 1999, original scientific article

Published in DiRROS: 22.01.2024; Views: 134; Downloads: 36
.pdf Full text (557,02 KB)

5.
Early glottic cancer : the influence of primary therapy on ultimate organ preservation
Hotimir Lešničar, Alojz Šmid, Branko Zakotnik, 1997, original scientific article

Published in DiRROS: 16.01.2024; Views: 146; Downloads: 33
.pdf Full text (215,84 KB)

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Using Ground Penetrating Radar (GPR) for detecting a crypt beneath a paved church floor
Marjana Zajc, Alojzij Grebenc, 2023, original scientific article

Abstract: After the discovery of an archive document regarding an underground crypt beneath the f loors of the Church of St. Margaret (Sv. Marjeta) in Dol pri Ljubljani, Slovenia, further research was carried out to confirm its presence. An area filled with construction waste was discovered during a recent small-scale renovation of the church floor. This finding suggested the potential underground chamber may have been partly filled in during one of the previous restorations. A non-invasive GPR study was carried out along eight profiles inside the church to prove the existence of an underground crypt. Results show the presence of an air-filled chamber, confirmed later by a hole drilled in the floor. Additional findings in the church archive and pictures taken by a camera, lowered through a drilled hole, revealed three previously unknown caskets in the crypt. According to the archives, two of them belong to Baron Wolf Daniel Erberg and his wife who died in 1783 and 1774, respectively.
Keywords: Ground Penetrating Radar (GPR), church Sv. Marjeta, crypt, underground chamber, Baron Erberg, Dol pri Ljubljani
Published in DiRROS: 16.01.2024; Views: 134; Downloads: 42
.pdf Full text (2,91 MB)

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Extracorporeal shock - wave lithotripsy in the management of bile duct stones
Alojz Pleskovič, Franc Jelenc, 1994, not set

Keywords: žolčnik, diagnostika, žolčni kamni
Published in DiRROS: 11.01.2024; Views: 161; Downloads: 37
.pdf Full text (460,86 KB)

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