1. The efficacy, safety and tolerability of canakinumab in the treatment of familial Mediterranean fever : a systematic review of the literatureMark Kačar, Sinisa Savic, Jeroen CH van der Hilst, 2020, review article Abstract: Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%-10% of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchicine in doses needed to prevent attacks. For these patients, Canakinumab, a full human antibody against IL-1[beta], has been approved recently by the FDA and EMA. In this article, we present a systematic review of the long-term efficacy, safety, and tolerability of Canakinumab in FMF patients who cannot tolerate colchicine or who are resistant to colchicine treatment.
Keywords: familial Mediterranean fever -- therapy -- review, monoclonal antibodies, canakinumab, anti-IL1 therapy
Published in DiRROS: 08.04.2021; Views: 1003; Downloads: 634
 Full text (463,72 KB)
This document has many files! More... |
