1. Priporočila za obravnavo bolnic z rakom jajčnikov, jajcevodov in s primarnim peritonealnim seroznim rakom v SlovenijiNina Kovačević, Barbara Šegedin, Sebastjan Merlo, Sonja Bebar, Ana Blatnik, Andrej Cokan, Branko Cvjetičanin, Nina Fokter Dovnik, Barbara Gazić, Biljana Grčar-Kuzmanov, Brigita Gregorič, Matej Horvat, Vid Janša, Jure Knez, Borut Kobal, Manja Šešek, Mateja Krajc, Maja Krajec, Mateja Lasič Pecev, Srdjan Novaković, Maja Pakiž, Maja Ravnik, Špela Smrkolj, Ksenija Strojnik, Erik Škof, Iztok Takač, Gregor Vivod, Vesna Zadnik, Helena Barbara Zobec Logar, 2022, professional article Keywords: rak (medicina), ginekološki raki, ginekologija, onkologija, epidemiologija, histopatologija, preživetje, diagnostika, zdravljenje, kirurgija
Published in DiRROS: 22.01.2026; Views: 348; Downloads: 232
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2. Quality of life of women with recurrent vulvar cancer treated with electrochemotherapyGregor Vivod, Ines Cilenšek, Nina Kovačević, Gregor Serša, Maja Čemažar, Sebastjan Merlo, 2025, original scientific article Abstract: Background: The quality of life of patients undergoing oncologic treatment has become an important issue in recent years. Owing to potential mutilation following surgery for vulvar cancer, more conservative approaches have evolved with the integration of new local ablative therapies, such as electrochemotherapy. The aim of this study was to determine the quality of life of women with vulvar cancer recurrence treated with electrochemotherapy for nonpalliative purposes. Patients and methods: Eleven patients with vulvar cancer recurrence were treated with electrochemotherapy from July 2020 to December 2023. Patients completed different questionnaires: the EuroQol - 5 Dimension (EQ-5D), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Vulva Cancer 34 (EORTC QLQ-VU34) and visual analog pain scale (VAS) before and one, three and six months after electrochemotherapy. As a control group, fifteen patients with vulvar cancer recurrence treated with wide local excision completed the EORTC QLQ-C30 and VAS questionnaires before surgery and three and six months after surgery. Results: No significant differences in EQ-5D scores were found between quality of life before electrochemotherapy and at each follow-up visit. A comparison of the EORTC QLQ-C30 scores between the electrochemotherapy and surgery groups showed a significant difference in physical functioning, fatigue, insomnia, and global health status three months after the procedure and in role, cognitive, social functioning and appetite loss six months after the procedure, all of which were in favor of the electrochemotherapy group. The EORTC QLQ-VU34 questionnaire showed improvements in urinary symptoms and symptoms related to scarring and mutilation of the external genitalia in the electrochemotherapy group. The VAS score did not differ significantly between the electrochemotherapy and surgical groups. Conclusions: The study showed that the quality of life after treatment with electrochemotherapy is better in some segments than after surgical treatment.
Keywords: bleomycin, electrochemotherapy, quality of life
Published in DiRROS: 16.01.2026; Views: 317; Downloads: 126
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3. Parenteralna prehrana na domu po onkološkem zdravljenju ginekoloških rakovNada Rotovnik-Kozjek, Mia Majerr, Nizra Palamar, Laura Petrica, Tatjana Slapar, Gregor Vivod, Denis Mlakar-Mastnak, 2024, published scientific conference contribution Keywords: ginekološki raki, parenteralna prehrana, raki rodil
Published in DiRROS: 06.09.2024; Views: 1258; Downloads: 633
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5. Treatment of vulvar cancer recurrences with electrochemotherapy : a detailed analysis of possible causes for unsuccessful treatmentGregor Vivod, Tanja Jesenko, Gorana Gašljević, Nina Kovačević, Maša Omerzel, Gregor Serša, Sebastjan Merlo, Maja Čemažar, 2023, original scientific article Abstract: Background. Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative treatment of gynecological cancers and mostly vulvar squamous cell carcinoma. Some tumors, however, fail to respond to electrochemotherapy. The biological features/determinants for the nonresponsiveness are not determined yet. Patient and methods. A recurrence of vulvar squamous cell carcinoma was treated by electrochemotherapy using intravenous administration of bleomycin. The treatment was performed by hexagonal electrodes according to standard operating procedures. We analyzed the factors that could determine nonresponsiveness to electrochemotherapy. Results. Based on the presented case of nonresponsive vulvar recurrence to electrochemotherapy, we hypothesize that the vasculature of the tumors prior to treatment may predict the response to electrochemotherapy. The histological analysis showed minimal presence of blood vessels in the tumor. Thus, low perfusion may reduce drug delivery and lead to a lower response rate because of the minor antitumor effectiveness of vascular disruption. In this case, no immune response in the tumor was elicited by electrochemotherapy. Conclusions. In this case, of nonresponsive vulvar recurrence treated by electrochemotherapy, we analyzed possible factors that could predict treatment failure. Based on histological analysis, low vascularization of the tumor was observed, which hampered drug delivery and distribution and resulted in no vascular disrupting action of electrochemotherapy. All these factors could contribute to ineffective treatment with electrochemotherapy.
Keywords: electrochemotherapy, bleomycin, vulvar cancer
Published in DiRROS: 25.07.2024; Views: 1287; Downloads: 521
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7. Obravnava bolnic s sumom na raka telesa materniceGregor Vivod, 2023, published scientific conference contribution Abstract: Z naraščajočo incidenco raka materničnega telesa v razvitem svetu je v prihodnjih letih
ocenjeno, da bo v Sloveniji za rakom materničnega telesa zbolelo več kot 400 bolnic letno. Z
obravnavo bolnic s sumom ali že znanim rakom telesa maternice se sreča vsak ginekolog.
Začetna obravnava bolnic vključuje anamnezo (družinska, osebna, ginekološka, sedanja),
splošni klinični pregled ter ginekološki klinični pregled z vaginalnim ultrazvokom. V nadaljnji
obravnavi sledi potrditev diagnoze (histeroskopija, abrazija ali aspiracijska biopsija) ter glede
na klinično presojo ustrezna slikovna diagnostika (CT, MR, PET-CT). Stremeti moramo k
optimalni in čimprejšnji diagnostični obravnavi na primarni in sekundarni ravni ter na
učinkovitem zdravljenju (operativni poseg, obsevanje, sistemsko zdravljenje) na terciarni ravni.
Po končanem zdravljenju morajo biti vse bolnice ustrezno sledene.
Keywords: rak maternice, ginekološki raki, ginekološka onkologija
Published in DiRROS: 30.05.2023; Views: 1309; Downloads: 634
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8. Rak telesa maternice : 7. Šola o ginekološkem raku2023, not set Abstract: Pred vami je zbornik, kjer so zbrani prispevki predavanj s področij, ki obravnavajo etiologijo in epidemiologijo raka materničnega telesa, predstavljene so najnovejše smernice obravnave bolnic z rakom materničnega telesa, novosti na področju patološke in molekularne diagnostike, na področju slikovne diagnostike ter dileme na področju operativnega zdravljenja. V zadnjem delu zbornika je predstavljeno sistemsko zdravljenje raka materničnega telesa ter zdravljenje z obsevanjem.
Published in DiRROS: 24.05.2023; Views: 1482; Downloads: 746
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