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Query: "author" (Gregor Serša) .

31 - 40 / 119
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31.
Adenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiation
Gregor Serša, Maja Čemažar, Zvonimir Rudolf, Albert-Peter Fras, 1999, original scientific article

Abstract: Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was found.
Published in DiRROS: 22.01.2024; Views: 132; Downloads: 33
.pdf Full text (410,27 KB)

32.
Cryosurgery combined with radiotherapy of tumors in mice
Albert-Peter Fras, Simona Kranjc Brezar, Maja Čemažar, Gregor Serša, 1999, original scientific article

Abstract: Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation.
Published in DiRROS: 22.01.2024; Views: 142; Downloads: 39
.pdf Full text (311,91 KB)

33.
Plasma membrane fluidity alterations in cancerous tissues
Marjeta Šentjurc, Mihael Sok, Gregor Serša, 1998, original scientific article

Abstract: Plasma membrane is a heterogeneous structure with several coexisting domains having different fluidity characteristics. It plays an important role in the control of cell growth, differentiation and transformation. Fluidity of the whole plasma membrane reflects the ordering and dynamics of phospholipid acyl chains in specific membrane domains, as well as the fraction of each domain inthe membrane. Changes in the membrane fluidity affect processes on the membrane such as transport, enzyme activities and expression of the redeptors.In this paper we present results of our recent electron paramagneticresonance (EPR) studies of plasma membrane fluidity characteristics, which take into account heterogeneous nature of the plasma membrane, By the computer simulation of the EPR spectra line-shapes, the number of coexisting domains in the plasma membrane, their relative portion inthe membrane as well as the ordering and dynamics of each domain be determined. Therefore, we could distinguish the contribution of the relative portion of each domain from the contribution of fulidity alterations in the domain to the entire fluidity changes in the membrane. Two examples will be discussed: membrane fluidity characteristics of excised lung tumor tissues andinfluence of microtubule depolymerizing agent vinblastine on membrane fluidity of vinblastine sensitive and resistant HeLa cells.
Published in DiRROS: 19.01.2024; Views: 128; Downloads: 31
.pdf Full text (1,91 MB)

34.
In vivo electroporation of the urinary bladder in mice
Peter Veranič, Kristijan Jezernik, Maja Čemažar, Gregor Serša, 1998, original scientific article

Published in DiRROS: 19.01.2024; Views: 127; Downloads: 36
.pdf Full text (556,60 KB)

35.
Vinblastine increases antitumor effectiveness of bleomycin
Maja Čemažar, Marija Auersperg, Gregor Serša, 1997, original scientific article

Abstract: In our previous vinblastine (VELBE) was shown to increase the plasma membrane fluidity. This effect of VELBE might be expolited for better transport of drugs through the plasma membrane. Bleomycin (BLM) is a highly cytotoxic drug when present inside the cells but has a hampered transport through the plasma membrane. The aim of the present study was to determine whether pretreatment with VELBE can increase the effect of BLM on intraperitoneal SA-1 tumors in mice. BLM and VELBE were used as single agents or in various combinations, i.e. VELBE and BLM injected simultanously, BLM injected 24 h before VELBE or VELBE injected 24 h before BLM. Mice survival was the end-point used for determining the effect of this combined treatments. VELBE and BLM as a single treatment significantly prolonged median survival time of study animals compared to controls. Furthermore, when VELBE and BLM were combined, all threetested combinations were more effective than VELBE or BLM as single treatments. The effect on animal survival was equal when VELBE was given 24 h after or simultanously with BLM. The longest survival, however was obtained when VELBE was injected 24 h before BLM. From these results we can conclude that the underlying mechanisms for more than additive effect of VELBE and BLM when VELBE was given 24 h before BLM could be attributed to an increased membrane fluidity, possibly in combination with a cell kinetic effect.
Published in DiRROS: 18.01.2024; Views: 114; Downloads: 25
.pdf Full text (1,28 MB)

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Seventh international symposium on neutron capture therapy for cancer
Gregor Serša, Janez Škrk, 1996, other component parts

Published in DiRROS: 16.01.2024; Views: 154; Downloads: 32
.pdf Full text (108,08 KB)

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Combined treatment of murine SA-1 tumors by human leukocyte interferon alpha and electrotherapy
Gregor Serša, Damijan Miklavčič, 1993, original scientific article

Keywords: rak (medicina), zdravljenje, elektroterapija, interferon
Published in DiRROS: 10.01.2024; Views: 144; Downloads: 34
.pdf Full text (454,89 KB)

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