1. Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer : long-term results of phase II OIGIT-01 TrialDanijela Golo, Jasna But-Hadžić, Franc Anderluh, Erik Brecelj, Ibrahim Edhemović, Ana Jeromen, Mirko Omejc, Irena Oblak, Ajra Šečerov Ermenc, Vaneja Velenik, 2018, original scientific article Abstract: The purpose of the study was to improve treatment efficacy for locally advanced rectal cancer (LARC) by shifting half of adjuvant chemotherapy preoperatively to one induction and two consolidation cycles. Patients and methods Between October 2011 and April 2013, 66 patients with LARC were treated with one induction chemotherapy cycle followed by chemoradiotherapy (CRT), two consolidation cycles, surgery and three adjuvant capecitabine cycles. Radiation doses were 50.4 Gy for T2-3 and 54 Gy for T4 tumours in 1.8 Gy daily fraction. The doses of concomitant and neo/adjuvant capecitabine were 825 mg/m2/12h and 1250mg/m2/12h, respectively. The primary endpoint was pathologic complete response (pCR). Results Forty-three (65.1%) patients were treated according to protocol. The compliance rates for induction, consolidation, and adjuvant chemotherapy were 98.5%, 93.8% and 87.3%, respectively. CRT was completed by 65/66 patients, with G % 3 non-hematologic toxicity at 13.6%. The rate of pCR (17.5%) was not increased, but N and the total-down staging rates were 77.7% and 79.3%, respectively. In a median follow-up of 55 months, we recorded one local relapse (LR) (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates were 64.0% (95% CI 63.89%64.11) and 69.5% (95% CI 69.39%69.61), respectively. Conclusions In LARC preoperative treatment intensification with capecitabine before and after radiotherapy is well tolerated, with a high compliance rate and acceptable toxicity. Though it does not improve the local effect, it achieves a high LR rate, DFS, and OS.
Keywords: rectal cancer, neoadjuvant chemotherapy, preoperative chemoradiotherapy
Published in DiRROS: 11.06.2024; Views: 705; Downloads: 373
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2. Dopolnilno obsevanje po ohranitveni operaciji raka dojk s sočasnim dodatkom doze na ležišče tumorja : izidi zdravljenjaMitja Anžič, Jasenka Gugić Kevo, Andreja Gojkovič Horvat, Danijela Golo, Maja Ivanetič Pantar, Tanja Marinko, Marija Snežna Paulin-Košir, Ivica Ratoša, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, kemoterapija
Published in DiRROS: 27.01.2023; Views: 1199; Downloads: 316
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3. Trastuzumab emtanzin in pooperativno obsevanje po operaciji raka dojk : preliminarni rezultati akutne toksičnosti sočasnega zdravljenjaEva Pribožič, Tina Pavlin, Mitja Anžič, Andreja Gojkovič Horvat, Maja Ivanetič Pantar, Danijela Golo, Jasenka Gugić Kevo, Marija Snežna Paulin-Košir, Tanja Marinko, Simona Borštnar, Anja Kovač, Ivica Ratoša, 2022, published professional conference contribution abstract Keywords: onkologija, rak dojke, kemoterapija
Published in DiRROS: 27.01.2023; Views: 1341; Downloads: 328
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4. Zdravljenje raka dojke z obsevanjemTanja Marinko, Marija Snežna Paulin-Košir, Andreja Gojkovič Horvat, Jasenka Gugić Kevo, Danijela Golo, Ivica Ratoša, Maja Ivanetič Pantar, 2020, not set Keywords: bolnice, zdravstveni nasveti
Published in DiRROS: 15.03.2021; Views: 2340; Downloads: 556
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5. Smernice za obravnavo bolnikov z malignimi limfomiBarbara Jezeršek Novaković, Gorana Gašljević, Danijela Golo, Monika Jagodic, Tanja Južnič Šetina, Jana Pahole Goličnik, Veronika Kloboves-Prevodnik, Gregor Kos, Marija Skoblar Vidmar, Uroš Smrdel, Marjeta Vovk, Lorna Zadravec-Zaletel, 2016, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: maligni limfomi, smernice, novotvorbe
Published in DiRROS: 27.05.2020; Views: 2658; Downloads: 755
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