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Query: "author" (Damjan Glavač) .

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1.
MicroRNAs and long non-coding RNAs : prospects in diagnostics and therapy of cancer
Nina Hauptman, Damjan Glavač, 2013, published scientific conference contribution

Abstract: Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potentialbiomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic andprognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish differentcancer types and classify their sub-types.Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development andprogression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficialin future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulationof many genes connected to survival and proliferation. Research is directed in development of useful markers fordiagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are alreadyin clinical trials.
Keywords: microRNAs, long non-coding RNAs, biomarker
Published in DiRROS: 22.03.2024; Views: 44; Downloads: 21
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2.
Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin
Vesna Todorović, Gregor Serša, Vid Mlakar, Damjan Glavač, Maja Čemažar, 2012, original scientific article

Abstract: Background. Electrochemotherapy is a local treatment combining chemotherapy and electroporation and is highly effective treatment approach for subcutaneous tumours of various histologies. Contrary to surgery and radiation, the effect of electrochemotherapy on metastatic potential of tumour cells has not been extensively studied. The aim of the study was to evaluate the effect of electrochemotherapy with bleomycin on the metastatic potential of human melanoma cells in vitro. Materials and methods. Viable cells 48 hours after electrochemotherapy were tested for their ability to migrate and invade through Matrigel coated porous membrane. In addition, microarray analysis and quantitative Real-Time PCR were used to detect changes in gene expression after electrochemotherapy. Results. Cell migration and invasion were not changed in melanoma cells surviving electrochemotherapy.Interestingly, only a low number of tumourigenesis related genes was differentially expressed after electrochemotherapy. Conclusions. Our data suggest that metastatic potential of human melanoma cells is not affected by electrochemotherapy with bleomycin, confirming safe role of electrochemotherapy in the clinics.
Published in DiRROS: 21.03.2024; Views: 60; Downloads: 36
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3.
Molekularna genetika dednega raka
Metka Ravnik-Glavač, Damjan Glavač, 2000, published scientific conference contribution

Published in DiRROS: 17.09.2019; Views: 2597; Downloads: 453
.pdf Full text (422,93 KB)

4.
Metode in tehnike določanja mutacij v molekularni onkologiji
Damjan Glavač, 2006, published professional conference contribution

Keywords: mutacije, onkologija, molekularna onkologija
Published in DiRROS: 16.09.2019; Views: 2364; Downloads: 497
.pdf Full text (208,27 KB)

5.
Molekularna genetika pljučnega raka
Damjan Glavač, Metka Ravnik-Glavač, 1998, published scientific conference contribution

Published in DiRROS: 16.09.2019; Views: 2292; Downloads: 458
.pdf Full text (330,07 KB)

6.
Medularni rak ščitnice - dedna bolezen
Damijan Bergant, Damjan Glavač, 2006, published scientific conference contribution

Published in DiRROS: 16.09.2019; Views: 1849; Downloads: 450
.pdf Full text (311,23 KB)

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