1. Cardiotoxicity of concomitant radiotherapy and trastuzumab for early breast cancerTanja Marinko, Jure Dolenc, Cvetka Bilban-Jakopin, 2014, original scientific article Abstract: Background. Trastuzumab therapy given in combination with one of several chemotherapy regimens is currently considered the standard of care for the treatment of early-stage, human epidermal growth factor receptor-2 (HER2) -positive breast cancer. The treatment with trastuzumab is due to a significant impact on the survival part of the standard adjuvant treatment of patients with HER2-positive breast cancer. Patients treated with postoperative breast or chest wall irradiation receive trastuzumab concomitant with radiotherapy. In a small proportion of patients trastuzumab causes cardiotoxicity. Preclinical findings indicate a radiosensibilizing effect of trastuzumab in breast cancer cells, but it is not yet clear whether it radiosensibilizes cells of healthy tissues too.Conclusions. Special attention is required when left breast or left thoracic wall is irradiated in patient receiving trastuzumab, because long-term effects of the concurrent treatment with trastuzumab and radiotherapy are not yet known. In an era where more patients are surviving a diagnosis of breast cancer, better understanding and earlier detection of therapy-induced cardiac toxicity will be of paramount importance.
Keywords: radiotherapy, cardiotoxicity, trastuzumab, early breast cancer
Published in DiRROS: 11.04.2024; Views: 57; Downloads: 32
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2. Persistent chromosomal aberrations in somatic cells in testicular cancer patients after different therapiesCvetka Bilban-Jakopin, Marjan Bilban, 2001, original scientific article Abstract: Background. The damage due to radiation or chemotherapeutic agents has been estimated successfully for the last 35 years from the numbers of the chromosome changes. This finding may serve as biological dosimeter. The aim ofthe study was to find persistent chromosomal aberrations in somatic cells intesticular cancer patients after different therapies. Patients and methods. This prospective study includes 60 patients with testicular tumours. With respect to the histological results and various therapies that they were giventhey were divided into four groups. Prior to treatment, we did not detectany deviations either in the genome picture of our patients or in that of the subjects of the control group without malignant disease. The changes inthe genome of individual cells after therapy were detected by the following tests: structural chromosomal aberrations (SCA) test, sister chromatid exchange (SCE) test and micronucleus (MN) test performed on binuclear lymphocytes. (Abstract truncated at 2000 characters)
Published in DiRROS: 26.01.2024; Views: 136; Downloads: 30
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3. Smernice zdravljenja raka dojkCvetka Bilban-Jakopin, Jožica Červek, Tanja Čufer, Darja Eržen, Rastko Golouh, Kristijana Hertl, Janez Lamovec, Jurij Lindtner, Elga Majdič, Bojana Pajk, Ana Pogačnik, Miljeva Rener, Barbara Vidergar-Kralj, Maja Primic-Žakelj, Janez Žgajnar, 2004, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 1760; Downloads: 459
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6. Onkološko genetsko svetovanje za dedni rak dojk in/ali jajčnikov - 4 letne izkušnje Skupine za Onkološko genetsko svetovanjeMateja Krajc, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, Srdjan Novaković, Miljeva Rener, Aleš Vakselj, Janez Žgajnar, 2004, published professional conference contribution abstract Published in DiRROS: 17.09.2019; Views: 2144; Downloads: 580
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7. Dokazovanje mutacij v BRCA1 genu z analizo talitvene krivulje PCR produktovSrdjan Novaković, Vida Stegel, Mateja Krajc, Janez Žgajnar, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, 2006, published scientific conference contribution Published in DiRROS: 17.09.2019; Views: 2373; Downloads: 591
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8. Dedni rak širokega črevesaMateja Krajc, Janez Žgajnar, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, Srdjan Novaković, Vida Stegel, 2006, published professional conference contribution Published in DiRROS: 17.09.2019; Views: 2027; Downloads: 534
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