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Query: "author" (Božidar Casar) .

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1.
Evaluation of water equivalency of Plastic waterTM for high-energy electron beams using IAEA TRS-398 code of practice
Božidar Casar, Urban Zdešar, Vlado Robar, 2004, original scientific article

Abstract: Electrochemotherapy (ECT) is a novel method for efficient tumor treatment in clinical environment. It combines local drug delivery and application of shorthigh voltage pulses, which permeabilize the plasma membrane by electroporation. Drug can enter only the cells with permeabilzed membrane. Recently, medical device CliniporatorTM for controlled electroporation was developed. Here, we present a web-application that extends the functionality of this medical device. The aim of the application is to collect, store and toallow the analysis of every ECT application using this medical device. The application helps transferring data collected by dev;ce during the electroporation process to the central database, and enables filling of medical records through the web forms. The application is based on technologies ASP, HTML, Flash, JavaScript, XML and others. The application main advantages are easy and rapid data access, scalability and independence of client computer operating system as well as easy application debugging and upgrading.
Published in DiRROS: 13.02.2024; Views: 98; Downloads: 21
.pdf Full text (146,09 KB)

2.
Tertiary collimator system for stereotactic radiosurgery with linear accelerator
Božidar Casar, 1998, original scientific article

Abstract: In the last decade, stereotactic radiosurgery (SRS) with linear accelerator (linac) has become an important irradiation technique for a variety of malignant and benign intracranial lesions. Although there exist some other radiosurgery techniques, linac based SRS meets the requirements needed for SRSwith low cost modifications. On of the most important additional parts of the equipment is tertiary collimator system which can be attached onto the linac head. We designed and built such system that can be easily fixed onto linac PHILIPS SL - 75/5 with 5 MV photon energy. In our department, we alreadyuse this linac for conventional radiation therapy. Our tertiary collimator system meets all the requirements important for this special modality of radiation therapy. It allows fine centering of the system and has ten various collimators with divergent circular openings having a nominal field diameter ranging from 1.0 cm to 4.0 cm at the isocenter. The accuracy ofthe system was checked by exposing x - ray films at various gantry positions, and recording misalignment of the beams. The width of penumbra was determined using two different dosimetry techniques (film dosimetry and diode measurements).
Published in DiRROS: 19.01.2024; Views: 137; Downloads: 34
.pdf Full text (1,30 MB)

3.
A novel approach for the definition of small-field sizes using the concept of superellipse
Ignasi Méndez Carot, Božidar Casar, 2021, original scientific article

Abstract: In radiotherapy, field sizes are defined in terms of the dimensions of the irradiation area. However, geometric square fields result in irradiation areas with rounded corners, which become almost elliptical for small fields. Superellipses are a family of curves encompassing shapes lying between ellipses and rectangles. The purpose of this work was to analyze the advantages and disadvantages of a novel approach that describes small-field sizes with superellipses. Square fields with nominal side lengths ranging from 0.5 to 10 cm were irradiated with two different linacs using 6 and 10 MV photon beams with and without flattening filters. Field size dimensions and output factors were measured by employing radiochromic films and the Radiochromic.com software. An alternative definition of equivalent square small-field size based on the superellipse (Sse) was introduced. The degree n of the superellipse for 10 cm nominal fields measured between 14.8 % 1.0 to 27.7 % 1.9. However, it decreased with the field size, down to between 2.26 % 0.10 and 2.64 % 0.15 for 0.5 cm nominal side lengths. A relation between the degree n and the equivalent square small-field size (Sclin) as defined by Cranmer-Sargison et al. [%A methodological approach to reporting corrected small field relative outputs,% Radiotherapy and Oncology 109, 350%355 (2013)] was found. For nominal side lengths of 10 cm, Sse was between 0.34 % 0.04% and 0.10 % 0.01% smaller than Sclin, while for 0.5 cm nominal side length Sse was between 9.5 % 0.6% and 7.4 % 0.7% smaller than Sclin. There was no significant difference in the goodness of the regression between using Sse or Sclin to fit field output factors with the function proposed by Sauer and Wilbert. Small fields were found to be more accurately characterized with superellipses. The advantages and disadvantages of describing field sizes with superellipses were examined. Field output factors can be derived with equivalent square small-field sizes based on the superellipse approach.
Keywords: superellipsa, small fields, dosimetry, radiotherapy
Published in DiRROS: 07.09.2022; Views: 380; Downloads: 235
.pdf Full text (2,84 MB)
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Book of abstracts
2000, not set

Published in DiRROS: 29.04.2021; Views: 810; Downloads: 261
.pdf Full text (962,38 KB)

7.
Novosti pri zdravljenju z obsevanjem : protonska terapija
Božidar Casar, 2019, published professional conference contribution (invited lecture)

Keywords: sevanja, onkologija, protonska terapija
Published in DiRROS: 03.04.2020; Views: 1683; Downloads: 497
.pdf Full text (268,95 KB)

8.
Radioterapija s protonskimi žarki
Božidar Casar, Primož Strojan, 2018, professional article

Abstract: Ob kirurškem in sistemskem zdravljenju je radioterapija eden od treh stebrov zdravljenja raka. Izjemen tehnološki razvoj na področju pospeševalnikov nabitih delcev je pripeljal do uveljavitve protonske radioterapije kot terapije izbora pri določenih skupinah bolnikov obolelih za rakom, v prvi vrsti otrok. Velika konkurenčnost med proizvajalci je botrovala postopnemu znižanju cen protonskih pospeševalnikov, ki so v zadnjih letih postali dostopni tudi državam, ki ne sodijo med najbogatejše. Kompleksnost radioterapije s protoni, velikost naprav in še vedno sorazmerno visoka cena so glavne ovire, da protonskih centrov že v tem trenutku ni več in da takšnega centra še vedno ni niti v Sloveniji niti ne drugod v jugovzhodni Evropi. Izbor bolnikov, ki bi imeli pomembno klinično korist od protonske radioterapije, je zahteven in tudi v svetu še ne docela dorečen. Prednost protonske pred konvencionalno fotonsko radioterapijo je v večji biološki učinkovitosti protonskih žarkov. Tudi fizikalno gledano so dozimetrične lastnosti protonskih žarkov bistveno ugodnejše glede sevalne obremenitve zdravih tkiv in rizičnih organov: večina njihove energije se sprosti na mestu, kjer je tumor, za razliko od fotonskih žarkov, kjer se večina energije sprosti v prvih nekaj centimetrih pod površino kože, kjer žarki vstopajo v telo. Podobno kot mnoge druge države je tudi Slovenija pred odločitvijo, kdaj in kako ustvariti pogoje za protonsko terapijo, ki pa jo bo treba sprejeti hitro in transparentno.
Keywords: radioterapija, protoni, Braggov vrh, protonsko zdravljenje
Published in DiRROS: 26.10.2018; Views: 3217; Downloads: 869
.pdf Full text (149,37 KB)

9.
Stereotaktična tehnika v radioterapiji
Božidar Casar, Primož Strojan, 2003, professional article

Published in DiRROS: 31.08.2018; Views: 2685; Downloads: 642
.pdf Full text (280,17 KB)

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