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Query: "author" (Barbara Jezeršek Novaković) .

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Treatment outcomes and relative dose intensity of chemotherapy in patients with advanced Hodgkin lymphoma
Samo Rožman, Barbara Jezeršek Novaković, Nina Ružić Gorenjec, Srdjan Novaković, 2022, original scientific article

Abstract: The present retrospective study was undertaken to investigate the association of relative dose intensity (RDI) with the outcome of patients with advanced stage Hodgkin lymphoma (HL) receiving ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and escalated BEACOPP regimens (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). A total of 114 patients with HL treated between 2004 and 2013 were enrolled for evaluation. The association of variables with overall survival (OS) and progression-free survival (PFS) was analysed using univariate and multivariate Cox proportional hazards models. The median age of patients was 39 years, and the majority were male and had stage IV disease. A total of 54 patients received ABVD and 60 received BEACOPP chemotherapy with 24 and four deaths, respectively. Patients in the BEACOPP group were significantly younger with lower Charlson comorbidity index (CCI) and better performance status in comparison with the ABVD group, making the comparison of groups not possible. In the ABVD group, RDI was not significantly associated with OS (P=0.590) or PFS (P=0.354) in a multivariate model where age was controlled. The low number of events prevented this analysis in the BEACOPP group. The age of patients was strongly associated with both OS and PFS; all statistically significant predictors for OS and PFS from univariate analyses (chemotherapy regimen, CCI, RDI, performance status) lost their effect in multivariate analyses where age was controlled. Based on these observations, it was concluded that RDI was not associated with OS or PFS after age is controlled, neither in all patients combined nor in the ABVD group.
Keywords: Hodgkin lymphoma, chemotherapy, outcome, primary treatment
Published in DiRROS: 23.09.2022; Views: 148; Downloads: 36
.pdf Full text (794,55 KB)

Trends in specialized palliative care referrals at an oncology center from 2007 to 2019
Lučka Boltežar, Barbara Jezeršek Novaković, Maja Ebert Moltara, 2021, original scientific article

Keywords: palliative care, primary site of cancer, early referral
Published in DiRROS: 21.09.2022; Views: 81; Downloads: 61
.pdf Full text (1,80 MB)
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Izzivi sodobnih pristopov onkološke zdravstvene nege in zdravljenja : zbornik predavanj
2009, proceedings of professional or unreviewed scientific conference contributions

Keywords: onkologija, karcinogeneza, vaskularni endotelijski rastni dejavnik, angiogeneza, biološka zdravila, zborniki
Published in DiRROS: 15.07.2020; Views: 1351; Downloads: 502
.pdf Full text (3,91 MB)

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