1. Diagnostic performance of p16/Ki-67 dual immunostaining at different number of positive cells in cervical smears in women referred for colposcopyUršula Salobir Gajšek, Andraž Dovnik, Iztok Takač, Urška Ivanuš, Tine Jerman, Simona Šramek Zatler, Alenka Repše-Fokter, 2021, original scientific article Abstract: . The aim of the study was to evaluate the diagnostic accuracy of p16/Ki-67 dual immunostaining (p16/ Ki-67 DS) in cervical cytology and the number of positive p16/Ki-67 cells to diagnose high grade cervical intraepithelial neoplasia (CIN2+) in colposcopy population. Subjects and methods. We performed an analysis on a subset cohort of 174 women enrolled within a large-scale randomised controlled human papillomavirus (HPV) self-sampling project organised as part of the population-based Cervical Cancer Screening Programme ZORA in Slovenia. This subset cohort of patients was invited to the colposcopy clinic, underwent p16/Ki-67 DS cervical cytology and had the number of p16/Ki-67 positive cells determined. Results. Among analysed women, 42/174 (24.1%) had histologically confirmed CIN2+. The risk for CIN2+ was increasing with the number of positive cells (p < 0.001). The sensitivity of p16/Ki-67 DS for detection of CIN2+ was 88.1%, specificity was 65.2%, positive predictive value was 44.6% and negative predictive value was 94.5%. Conclusions. Dual p16/Ki-67 immunostaining for the detection of CIN2+ has shown high sensitivity and high negative predictive value in our study, which is comparable to available published data. The number of p16/Ki-67 positive cells was significantly associated with the probability of CIN2+ detection. We observed a statistically significant and clinically relevant increase in specificity if the cut-off for a positive test was shifted from one cell to three cells.
Keywords: cervical cytology, high-grade dysplasia, p16/Ki-67 immunostaining
Published in DiRROS: 22.07.2024; Views: 205; Downloads: 75
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2. Incidence of positive peritoneal cytology in patients with endometrial carcinoma after hysteroscopy vs. dilatation and curettageAndraž Dovnik, Bojana Crnobrnja, Branka Žegura Andrić, Iztok Takač, Maja Pakiž, 2017, original scientific article Abstract: Background. The aim of the study was to compare the frequency of positive peritoneal washings in endometrial cancer patients after either hysteroscopy (HSC) or dilatation and curettage (D&C). Patients and methods. We performed a retrospective analysis of 227 patients who underwent either HSC (N = 144) or D&C (N = 83) and were diagnosed with endometrial carcinoma at the University Medical Centre Maribor between January 2008 and December 2014. The incidence of positive peritoneal cytology was evaluated in each group. Results. There was no overall difference in the incidence of positive peritoneal washings after HSC or D&C (HSC = 13.2%; D&C = 12.0%; p = 0.803). However, a detailed analysis of stage I disease revealed significantly higher rates of positive peritoneal washings in the HSC group (HSC = 12.8%; D&C = 3.4%; p = 0.046). Among these patients, there was no difference between both groups considering histologic type (chi-square = 0.059; p = 0.807), tumour differentiation (chi-square = 3.709; p = 0.156), the time between diagnosis and operation (t = 0.930; p = 0.357), and myometrial invasion (chi-square = 5.073; p = 0.079). Conclusions. Although the diagnostic procedure did not influence the overall incidence of positive peritoneal washings, HSC was associated with a significantly higher rate of positive peritoneal cytology in stage I endometrial carcinoma compared to D&C.
Published in DiRROS: 03.06.2024; Views: 322; Downloads: 187
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3. Postopki za obravnavo bolnic z rakom materničnega vratu v SlovenijiMarjetka Uršič-Vrščaj, Špela Smrkolj, Primož Petrič, Maja Primic-Žakelj, Matej Bračko, Vida Stržinar, Borut Kobal, Branko Cvjetičanin, Andrej Možina, Leon Meglič, Andrej Zore, Barbara Šegedin, Vesna Robič, Albert-Peter Fras, Sonja Bebar, Aleš Vakselj, Milan Baškovič, Astrid Djurišić, Olga Cerar, Iztok Takač, Andraž Dovnik, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: smernice
Published in DiRROS: 09.06.2020; Views: 2266; Downloads: 588
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4. Smernice za obravnavo bolnic z rakom materničnega vratu v SlovenijiMarjetka Uršič-Vrščaj, Špela Smrkolj, Primož Petrič, Maja Primic-Žakelj, Matej Bračko, Vida Stržinar, Borut Kobal, Branko Cvjetičanin, Andrej Možina, Leon Meglič, Andrej Zore, Barbara Šegedin, Vesna Robič, Albert-Peter Fras, Sonja Bebar, Aleš Vakselj, Milan Baškovič, Astrid Djurišić, Olga Cerar, Iztok Takač, Andraž Dovnik, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: smernice
Published in DiRROS: 05.06.2020; Views: 2335; Downloads: 580
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5. Postopki za obravnavo bolnic z rakom materničnega vratu v SlovenijiMarjetka Uršič-Vrščaj, Špela Smrkolj, Primož Petrič, Maja Primic-Žakelj, Matej Bračko, Vida Stržinar, Borut Kobal, Branko Cvjetičanin, Andrej Možina, Leon Meglič, Andrej Zore, Barbara Šegedin, Vesna Robič, Albert-Peter Fras, Sonja Bebar, Aleš Vakselj, Milan Baškovič, Astrid Djurišić, Olga Cerar, Iztok Takač, Andraž Dovnik, 2012, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: smernice
Published in DiRROS: 04.06.2020; Views: 1668; Downloads: 0 |
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7. Nove smernice za zdravljenje predrakavih sprememb materničnega vratuIztok Takač, Špela Smrkolj, Urška Ivanuš, Darja Arko, Andraž Dovnik, 2015, published scientific conference contribution abstract (invited lecture) Keywords: maternični vrat, predrakave spremembe, zdravljenje, smernice
Published in DiRROS: 09.04.2020; Views: 1994; Downloads: 570
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8. Novosti v zdravljenju raka dojk in raka jajčnikov ASCO, Annual Meeting, Chicago, 1.-5. 6. 2012Iztok Takač, Andraž Dovnik, 2012, popular article Keywords: dojka, novotvorbe, jajčnik, novotvorbe, zdravljenje, strokovna srečanja, ginekologija
Published in DiRROS: 31.08.2018; Views: 3226; Downloads: 883
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