Stranski učinki ob zdravljenju rakavih bolezni z zaviralci tirozinskih kinaz
Zaviralci tirozin-kinaz so multitarčna zdravila, ki prek zaviranja različnih celičnih procesov učinkujejo pri več vrstah rakavih boleznih. Čeprav so stranski učinki ob zaviralcih tirozinskih kinaz v splošnem prenosljivi, pa so lahko tudi resni in povzročajo nemalo preglavic bolnikom, ki prejemajo zdravila dolgotrajno. Pogosto je potrebno zmanjšanje odmerkov ali prehodna ukinitev, redkeje pa se odločimo za trajno prekinitev zdravljenja. Značilni so kožna toksičnost, kardiovaskularni zapleti, težave gastrointestinalnega trakta - predvsem diareja, nepravilno delovanje ščitnice in utrujenost ob zdravljenju rakave bolezni.
Tyrosine kinase inhibitors are multicentric drugs that inhibit different cellular processes and are effective in the treatment of many types of cancer. Although the side effects of tyrosine kinase inhibitors are generally tolerable, they may also be serious and cause numerous problems in patients receiving long-term medication. Dosage reductions or transient withdrawal are often required, but only rarely is the treatment permanently discontinued. Typical complications include skin toxicity, cardiovascular complications, problems in the gastrointestinal tract, in particular diarrhoea, thyroid malfunction, and treatment-specific fatigue. The present article lays out the most common side effects of treatment with tyrosine kinase inhibitors.
by Authors
2018
2018-10-26 11:02:39
1060
tarčna zdravila, zaviralci tirozinskih kinaz, stranski učinki
targeted drugs, tyrosine kinase inhibitors, side effects
Marina
Mencinger
70
UDK
4
616-006
ISSN pri članku
9
1408-1741
DOI
15
10.25670/oi2018-004on
COBISS_ID
3
2990971
OceCobissID
13
65324032
RAZ_Mencinger_Marina_i2018.pdf
103429
Predstavitvena datoteka
2018-10-26 11:02:40