20.500.12556/DiRROS-9091 Obsevanje bolnic z eno do tremi pozitivnimi pazdušnimi bezgavkami po mastektomiji - da ali ne Patients with One to Three Positive Axillary Lymph Nodes Following Mastectomy: Dilemma Whether to Use Postoperative Radiation Therapy or No Obsevanje po modificirani radikalni mastektomiji (MRM) pri bolnicah z 1-3 pozitivnimi pazdušnimi bezgavkami je že vrsto let predmet strokovnih razprav. Kljub čedalje pogostejšim dokazom o dobrobiti obsevanja po MRM pri bolnicah s t. i. vmesnim tveganjem za lokalno ponovitev pa še vedno ostajajo številna protislovja in nerešena vprašanja o pomenu učinka izboljšane lokalne kontrole na preživetje, o posledicah pozne kardiotoksičnosti obsevanja ob uporabi sodobnih sistemskih zdravil ter o izbiri območja obsevanja in podskupin bolnic, primernih za obsevanje. Večina mednarodnih smernic in sporazumov svetuje obsevanje po MRM v podskupinah bolnic z 1-3 pozitivnimi pazdušnimi bezgavkami, s tehtnim premislekom med koristjo in tveganjem tega zdravljenja. Radiation therapy following a modified radical mastectomy (MRM) applied in the patients with one to three positive axillary lymph nodes has long been a primary issue of many debates. Despite most convincing evidence of the benefits of the post-MRM radiation therapy of the patients at moderate risk for local recurrence, a number of issues and questions, such the effect of improved local control on survival as well as the late cardiotoxic sequelae of radiation therapy irrespective of the most up-to-date systemic therapy, accurate radiation field planning and proper selection of subgroups of patients eligible for radiation, have remained unresolved. In general, the majority of international guidelines and agreements recommend, though not without a careful benefit/risk assessment, performing post-MRM radiation therapy in the subgroup of patients with one to three positive axillary lymph nodes. true false true Slovenski jezik Angleški jezik by Authors Neznano 2018-08-31 13:36:37 2018-08-31 13:36:37 2022-08-24 17:57:02 0000-00-00 00:00:00 2010 0 0 str. 144-146, 170 št. 2 Letn. 14 dec. 2010 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.19-006.6-089:615.849 1408-1741 URN:NBN:SI:doc-MEPJBNQH 1056379 65324032 RAZ_But_Hadzic_Jasna_i2010.pdf RAZ_But_Hadzic_Jasna_i2010.pdf 1 73F6E69A5C6850231F125C8123BF5F80 2328a796efca8db6310e9a997b1787ca17d33bd9fdb3c75e6f7e39bff7e6cba0 725362ce-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/cdc5adb3-6490-476f-9ccc-cda88fd0373e https://dirros.openscience.si/Dokument.php?lang=slv&id=10872 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0