20.500.12556/DiRROS-8795 Slabost in bruhanje pri bolnikih na sistemskem zdravljenju raka Systemic Treatment-Induced Vomiting and Nausea Preprečevanje ter kontrola slabosti in bruhanja sta med najpomembnejšimi nalogami pri podpornem zdravljenju bolnikov z rakom. Poznamo akutno, pozno in anticipatorno slabost, ki so povzročene s citostatsko terapijo, ter kronično slabost in bruhanje pri bolnikih z napredovalim rakom. Osnova antiemetskega zdravljenja je nevrokemijska kontrola slabosti in bruhanja. V sluznici prebavil in v osrednjem živčevju so številni serotoninski, nevrokininski, dopaminski, histaminski in drugi receptorji, na katere se vežejo ustrezni prenašalci. Mnogi antiemetiki delujejo po mehanizmu kompetitivne inhibicije prek teh receptorjev tako v perifernem kot v osrednjem živčevju. Prevention and control of nausea and vomiting are of paramount importance in the treatment of cancer patients. The most commonly described types are acute, delayed, and anticipatory chemotherapyinduced nausea and vomiting and chronic nausea and vomiting in advanced cancer patients. The basis for antiemetic therapy is the neurochemical control of both. Although the exact mechanism is not well understood,the peripheral neuroreceptors and the chemoreceptor trigger zone are known to contain receptors for serotonin, substance P, dopamine, histamine, opioids, and numerous other endogenous neurotransmitters. Many antiemetics act by competitively blocking the receptors for these substances, thereby inhibiting stimulation of peripheral nerves at the chemoreceptor zone, and perhaps at the vomiting center. true false true Slovenski jezik Angleški jezik by Authors Neznano 2018-08-31 13:30:32 2018-08-31 13:30:32 2022-08-24 17:31:01 0000-00-00 00:00:00 2009 0 0 BSDOCID145293; str. 51-53 št. 1 Letn. 13 2009 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1408-1741 URN:NBN:SI:doc-261AOQ4H 25711321 65324032 RAZ_Borstnar_Simona_i2009.pdf RAZ_Borstnar_Simona_i2009.pdf 1 F22DCFC6BDF27280AC7073037A0C2407 f233ca7b42bf18d027e42ecf93df8c666cc8394bbcf78d2c46c6f6008d76ca4f 5ea32cb2-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/dd7174a5-5e6f-4e5b-aa01-c69ef2428d99 https://dirros.openscience.si/Dokument.php?lang=slv&id=10576 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0