20.500.12556/DiRROS-8779 Vpliv pooperativne radioterapije pri multimodalnem zdravljenju lokalnmo napredovalega raka dojke The impact of radiotherapy in multimodal management of locally advanced breast cancer We retrospectively analyzed the data from 55 patients treated for noninflammatory locally advanced breast cancer (LABC) with neoadjuvant chemotherapy and surgery with or without radiotherapy. The mean follow-up was 55 months. The purpose was to evaluate and compare the impact of postoperative radiotherapy, whether it was indicated on the basis of clinical stage at presentation of the disease or on downstaged pathological disease after initial chemotherapy. The 3-year overall survival (OS) was 74%, disease-free survival (DFS) 73% and relapse-free survival (RFS) 87%. The OS and DFS benefit was seen in those receiving radiation, with a mean OS of 89 months vs. 68 months (p=0.029) and mean DFS of 72 months vs. 54 months (p=0.029). Total LRR was 11% (8% vs. 17% in no RT group, p=0,349) and mean RFS of 95 months vs. 86 months (p=0.164). Significantly lower OS and DFS of the patients who were not treated with radiotherapy suggest that the indication for radiation treatment should be based on clinical pre-chemotherapy stage rather than pathological post-chemotherapy stage for non-inflammatory LABC. true false true Slovenski jezik Ni določen by Authors Neznano 2018-08-31 13:30:11 2018-08-31 13:30:11 2022-08-24 17:29:46 0000-00-00 00:00:00 2008 0 0 BSDOCID143368; str. 89-93 št. 2 Letn. 12 2008 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1408-1741 URN:NBN:SI:doc-FHL0FV8M 25344473 65324032 RAZ_But_Hadzic_Jasna_i2008.pdf RAZ_But_Hadzic_Jasna_i2008.pdf 1 10BB7E024537557199A5E794B51B9051 d3f8d3173fd4f89f65c4f95272e2542857539e0b1cbe393cdd1988b52c12090d 5d89e4eb-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/740201f0-987a-4138-b61f-d33b753a2ca2 https://dirros.openscience.si/Dokument.php?lang=slv&id=10560 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0