20.500.12556/DiRROS-8628 Progresivna multifokalna levkoencefalopatija po rituksimabu pri bolniku z recidivnim limfomom plaščnih celic v popolni remisiji Progressive multifocal leukoencephalopathy following rituximab therapy in a patient with a relapsed mantle cell lymphoma in complete remission Progresivna multifokalna levkoencefalopatija (PML) je redko in običajno smrtno demielinizacijsko obolenje možganov, ki se razvije skoraj izključno pri bolnikih z imunsko pomanjkljivostjo in je posledica reaktivacije latentne okužbe s polioma virusom JC. V zadnjih letih so opisani tudi primeri PML po zdravljenju z rituksimabom. Predstavljamo naš prvi potrjeni primer PML pri 55-letnem HIV-negativnem bolniku z recidivnim limfomom plaščnih celic, pri katerem smo raka uspešno zdravili s kemoterapijo in rituksimabom ter z avtologno presaditvijo perifernih krvotvornih matičnih celic (PKMC). S primerom želimo opozoriti na pomembnost PML v diferencialni diagnozi pri bolnikih z napredujočo nevrološko simptomatiko in imunsko pomanjkljivostjo po zdravljenju limfoma z rituksimabom ter pomembnost zgodnjega prepoznavanja te bolezni z dokazom JC-virusne okužbe v likvorju ali v vzorcu stereotaktične biopsije možganov. Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal demyelinating disease of the brain that is developed almost exclusively in patients with immunodeficiency and is a result of a latent infection with the JC polyomavirus. In recent years, several cases of PML have been reported following rituximab therapy. We present our first confirmed case of PML in a 55-year-old HIV-negative patient with a relapsed mantle cell lymphoma who was treated successfully with chemotherapy, rituximab and autologous transplantation of peripheral haematopoietic stem cells (PHSC). By reporting this case we wish to draw attention to the importance of PML in differential diagnosis of patients with a progressing neurological symptoms and immunodeficiency following lymphoma treatment with rituximab and stress the importance of early detection of this disease with evidence of JC virus infection in the cerebrospinal fluid or stereotactic brain biopsy sample. true false true Slovenski jezik Angleški jezik by Authors Neznano 2018-08-31 13:27:03 2018-08-31 13:27:03 2022-08-16 10:08:55 0000-00-00 00:00:00 2012 0 0 Soavtorji: Matej Horvat, Mara Popović, Barbara Jezeršek Novaković; str. 48-51, 56 št. 1 Letn. 16 jun. 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.15-006.6-08-06:616.831 1408-1741 URN:NBN:SI:doc-9M4PZWBN 1320571 65324032 RAZ_Ros-Opaskar_Tanja_i2012.pdf RAZ_Ros-Opaskar_Tanja_i2012.pdf 1 3AA9BC9139BD38E6704536330E2F508A 87a814f126edb0057e2c92a91a53430657a381b3da7d94bc6262c072ffa11b4b 53a125a7-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/f34e208b-884f-48c1-8fe8-6e3570630046 https://dirros.openscience.si/Dokument.php?lang=slv&id=10409 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0