Cirkulirajoče tumorske celice in njihov pomen pri raku dojke : pregled izsledkov dosedanjih raziskav
Circulating tumor cells (CTCs) are epithelial tumor cells detected in the peripheral blood of patients with solid malignant tumors. They originate from the primary tumor or metastatic sites. New techniques have been developed to isolate and characterise these cells, including the FDA-approved CellSearch, which are using mainly cytometric/antibody-based and molecular approaches. Recent advances in theories regarding metastasis support the role of early release of tumor cells in the neoplastic process. It has been found that phenotypic variation exists between the primary tumor and CTCs. Of particular interest is the difference found between primary tumor and CTC HER-2 status in both metastatic and early breast cancer. CTC enumeration has been incorporated into different fields of oncology as a prognostic marker, a tool to monitor therapy response, and a method to understand basic tumor characteristics. But currently, there is still no role for CTCs in clinical practice.
by Authors
2011
2018-08-31 13:26:19
1060
tumor, onkologija, dojke, prognoza, zasevki
Tanja
Marinko
70
Tamara
Lah Turnšek
70
Gregor
Serša
70
UDK
4
618.19-006.6
ISSN pri članku
9
1408-1741
URN
14
URN:NBN:SI:doc-B98AV2ZQ
COBISS_ID
3
1194619
OceCobissID
13
65324032
RAZ_Marinko_Tanja_i2011.pdf
343897
Predstavitvena datoteka
2018-08-31 13:26:20