20.500.12556/DiRROS-8133 Radioterapija sekundarnih tumorjev jeter Radiotherapy of secondary liver cancer Sekundarni tumorji jeter, med njimi zasevki tumorjev gastrointestinalnega trakta, raka dojk in pljuč pogosto povzročajo simptome, ki niso obvladljivi s sistemskim zdravljenjem. V primeru difuznih jetrnih zasevkov lahko z obsevanjem celotnih jeter hitro, učinkovito in z majhnimi stroški dosežemo dobro paliacijo simptomov z blagimi neželenimi učinki. Ko je zasevkov manj in je tudi obseg bolezni v telesu manjši, lahko pri izbranih bolnikih z dodatnim lokalnim (ablativnim) zdravljenjem jetrnih zasevkov dosežemo izboljšanje časa do progresa bolezni in celokupnega preživetja. V nadaljevanju prispevka sta opisana radiacijska poškodba jeter in obsevanje jeter z različnimi radioterapevtskimi tehnikami, med katerimi izberemo najustreznejšo glede na obseg bolezni, velikost jetrnih zasevkov, simptome, laboratorijske izvide in stanje zmogljivosti bolnika. Liver is commonly involved in a metastatic setting of gastrointestinal, lung and breast cancers. Symptoms of liver metastases are rarely mitigated by systemic (palliative) treatments only. Whole or partial liver radiotherapy is a cost-effective treatment option with minimal treatment toxicity to offer the mitigation of symptoms to patients with diffuse liver metastatic involvement. This treatment approach is different (and sometimes with curative intent) for selected patients with a lower tumour burden and an oligo-metastatic disease. Local ablative treatments of limited number and size of liver metastases show improvements in local control of the tumour, disease-free survival and overall survival. This article describes radiation induced liver disease and different radiation therapy approaches that can be chosen while taking into account the burden of the disease, size and number of liver metastases, symptoms, laboratory tests, possibilities of other local treatments and the clinical performance status of the patient. radioterapija sekundarni tumorji jeter paliativno obsevanje radiotherapy secondary liver cancer palliative radiotherapy true false true Slovenski jezik Angleški jezik by Authors Neznano 2017-12-13 11:23:03 2017-12-13 11:23:03 2022-08-16 09:55:18 0000-00-00 00:00:00 2017 0 0 str. 30-35 št. 1 Letn. 21 jun. 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1408-1741 2716539 65324032 RAZ_Ratosa_Ivica_i2017.pdf RAZ_Ratosa_Ivica_i2017.pdf 1 87EC1B55E184A98D2F69DD1EE1849805 c9237703407d2dbe2edc08be4ce67e4ffeb255952cfb0c957c5e58944ee998c4 43b1a682-17b5-11ed-b6b8-001a4af901a5 20.500.12556/dirros/5894c340-6417-4435-9148-37b0e5fa3386 https://dirros.openscience.si/Dokument.php?lang=slv&id=10023 Onkološki inštitut Ljubljana Onkologija : strokovni časopis za zdravnike 0 0 0