20.500.12556/DiRROS-5828 Fluid therapy: double-edged sword during critical care? Fluid therapy is still the mainstay of acute care in patients with shock or cardiovascular compromise. However, our understanding of the critically ill pathophysiology has evolved significantly in recent years.The revelation of the glycocalyx layer and subsequent research has redefined the basics of fluids behavior in the circulation. Using less invasive hemodynamic monitoring tools enables us to assess the cardiovascular function in a dynamic perspective. This allows pinpointing even distinct changes induced by treatment, by postural changes, or by interorgan interactions in real time and enables individualized patient management. Regarding fluids as drugs of any other kind led to the need for precise indication, way of administration, and also assessment of side effects.We possess now the evidence that patient centered outcomes may be altered when incorrect time, dose, or type of fluids are administered. In this review, three major features of fluid therapy are discussed: the prediction of fluid responsiveness, potential harms induced by overzealous fluid administration, and finally the problem of protocol-led treatments and their timing. true false true Angleški jezik Neznan jezik © 2015 Jan Benes et al. Delo ni kategorizirano 2016-05-11 04:03:05 2018-03-21 11:18:26 2022-08-11 03:33:52 0000-00-00 00:00:00 2015 0 0 [str. 1-14] čl. 729075 Letn. 2015 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2314-6141 616 10.1155/2015/729075 737955 30624729 http://www.hindawi.com/journals/bmri/2015/729075/ 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=5935 Splošna bolnišnica Celje 0 0 0