20.500.12556/DiRROS-32377 Management and outcomes of invasive procedures in individuals with hemophilia A on emicizumab prophylaxis a single center experience Prophylactic treatment with emicizumab has become an important and effective bleeding prevention for people with hemophilia A (PwHA). Perioperative management of PwHA using emicizumab prophylaxis is still challenging due to a lack of experience. Medical records of perioperative management and outcomes were reviewed, and data were collected for adult PwHA receiving emicizumab and undergoing surgical procedures between August 2019 and July 2022 at the University Medical Center Ljubljana. Twelve surgical procedures were performed in eight PwHA (one with FVIII inhibitors) while on emicizumab prophylaxis. Three minor procedures included cataract surgery, cystoscopic lithotripsy, and percutaneous coronary intervention. Nine major surgeries included four osteosyntheses, necrectomy of chronic osteomyelitis with new ankle arthrodesis, two below-knee amputations, total knee replacement, and placement of ventriculostomy after a spontaneous intraventricular hemorrhage. No major bleeds, thrombotic events or deaths, or new inhibitors appeared. Our real-world experience demonstrates that minor and major surgeries can be performed safely in PwHA on emicizumab prophylaxis. Additional data are needed to optimize dosing/duration of additional hemostatic agents in diverse invasive procedures and complex clinical situations. emicizumab perioperative care hemophilia A prophylaxis invasive procedures true false true Angleški jezik Ni določen Neznano 2026-09-09 13:12:33 2026-09-09 13:12:34 2026-09-10 03:50:15 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 1. 2024; str. 597-607 no. 4 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 2038-8330 10.3390/hematolrep15040062 179933699 RAZ_Rener_Karla_2023.pdf RAZ_Rener_Karla_2023.pdf 1 49F4BDFD8D664534782336FF91FCD21C 91ca2f4986bde87ac19d1a2cc770c64278b7bcb219a8efbf7c453aa38afbfe83 b490084a-ac2e-11f1-92ee-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50644 https://www.mdpi.com/2038-8330/15/4/62 1 9aa41cc8-ac2e-11f1-92ee-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50643 Univerzitetni klinični center Ljubljana 0 0 0