20.500.12556/DiRROS-32350 Exosomal MicroRNAs as theranostic tools in type 2 diabetes and its complications mechanistic insights and clinical implications Type 2 diabetes is a chronic and progressive metabolic disease, with a steadily increasing global incidence and prevalence, representing a major public health concern due to its substantial impact on morbidity and mortality. Type 2 diabetes is characterized by defective insulin secretion and peripheral insulin resistance, resulting in dysregulated glucose homeostasis. Optimal disease management is critical due to its association with multiple systemic complications, including diabetic retinopathy, nephropathy, neuropathy, foot ulcers, cardiomyopathy, and diabetes-related cognitive impairment. The involvement of exosomes in the initiation and progression of type 2 diabetes has recently gained considerable attention. These nanosized vesicles, secreted by virtually all cell types, play a pivotal role in mediating intercellular communication. This review highlights the potential of exosomes and their molecular cargo, particularly microRNAs, as endogenous biomarkers for the detection and monitoring of type 2 diabetes and its associated complications, while also exploring their emerging therapeutic applications. type 2 diabetes diabetic complications obesity insulin resistance extracellular vesicles exosomes MiRNAs biomarkers therapy true false true Angleški jezik Ni določen Neznano 2026-09-08 10:19:46 2026-09-08 10:19:47 2026-09-09 03:47:07 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 9. 2026; str. 1-22 [article no.] 79 Vol. 18 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379 1758-5996 10.1186/s13098-026-02114-2 290324483 RAZ_Vukelic_Iva_2026.pdf RAZ_Vukelic_Iva_2026.pdf 1 B14103D7D3636D2F6890F8599CDF7FC8 2937024ee67ffdfc2a7dab6c4e391b945384e10ccbb34169ca2a77a06e456ebe d98f70c1-ab5e-11f1-b028-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50595 https://link.springer.com/article/10.1186/s13098-026-02114-2 1 29f88be7-ab5e-11f1-b028-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50593 Univerzitetni klinični center Ljubljana 0 0 0