20.500.12556/DiRROS-32252 Non-thermal ablation and drug delivery by electroporation expanding current indications beyond cancer and cardiac treatment Background. Electroporation-Based Treatments and Therapies (EBTTs) – electrochemotherapy, irreversible electroporation, pulsed field ablation, and gene electro-transfer – use short, high-voltage electric pulses to permeabilize cell membranes, enabling non-thermal tissue ablation and enhanced local drug delivery. Although EBTTs have been used clinically for over three decades, primarily in oncology, their adoption remains limited compared to thermal ablation modalities. In contrast, cardiac pulsed field ablation (PFA) has seen rapid adoption since the first FDA device approval in December 2023. Conclusions. This expert opinion paper reviews the current clinical landscape of EBTTs in oncology and cardiac arrhythmia treatments, and focuses on emerging non-oncological and non-cardiac applications, including endoscopic pulsed electric field therapy for type 2 diabetes, bronchial rheoplasty for chronic bronchitis, bleomycin electrosclerotherapy for vascular malformations, nanosecond PFA for benign thyroid nodules, and electroporation-mediated gene delivery – and identifies key barriers to wider adoption: insufficient randomized evidence, lack of validated treatment planning tools, fragmented reimbursement, and limited standardization. We outline measures to facilitate clinical translation. elektroporacija ablacija s pulzirajočim poljem elektrokemoterapija ireverzibilna elektroporacije genska elektrotransfekcija electroporation pulsed field ablation electrochemotherapy irreversible electroporation gene electrotransfer true false true Association of Radiology and Oncology Ljubljana Angleški jezik Slovenski jezik by Authors Neznano 2026-09-02 14:42:47 2026-09-02 14:42:48 2026-09-03 03:56:45 0000-00-00 00:00:00 2026 0 0 16 str. issue Vol. 2026 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2026-01-01 602.621 1318-2099 10.2478/raon-2026-0040 287787523 https://reference-global.com/article/10.2478/raon-2026-0040 1 d1ec9411-a6cb-11f1-8a94-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50350 RAZ_Miklavcic_Damijan_2026.pdf RAZ_Miklavcic_Damijan_2026.pdf 1 D2BD5C87709A815CE5C6A1845441CBD5 57f77ce5dc9d19e3941d99651c5ca7e8be17a8837be68f1464752edad391119f faebbc2a-a6cb-11f1-8a94-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50351 Onkološki inštitut Ljubljana Društvo radiologije in onkologije 0 0 0