20.500.12556/DiRROS-32248 PBPKO an ontology for standardizing and harmonizing physiologically based pharmacokinetic (PBPK) models Physiologically Based Pharmacokinetic (PBPK) Modelling have emerged as a critical method in pharmaceutical and environmental sciences. Despite its widespread adoption, inconsistent vocabulary used across models, software platforms, and literature remains a significant challenge. Such inconsistency limits the potential for data harmonization and model interoperability. This gap also hinders the adoption of machine-readable semantic technologies that could enhance PBPK model reporting, validation, and interoperability. To address this gap, we developed PBPKO (Physiologically Based Pharmacokinetic Ontology), a dedicated ontology for the kinetic modelling community. PBPKO captures mechanisms and terminology commonly used in PBPK modelling, including concepts related to physiological parameters, biochemical parameters, biological processes, enzymes, transporters, and related concepts. As of release of v2026-07-15, the ontology comprises 858 classes and 7 object properties native to PBPKO. To support semantic interoperability within the broader biomedical ontology ecosystem, PBPKO is aligned with upper-level ontologies such as the Basic Formal Ontology (BFO) and the Relation Ontology (RO), and reuses terms from established resources including Gene Ontology (GO) and the Ontology for Biomedical Investigations (OBI). mathematical modelling visualization types physiologically based pharmacokinetic model semantics ontology matematično modeliranje ontologija semantika true false true Elsevier Nizozemska Angleški jezik Slovenski jezik © 2026 The Authors. Neznano 2026-09-02 12:26:16 2026-09-02 12:26:16 2026-09-03 03:56:41 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 19. 8. 2026; str. 1-9 Vol. 39, 100445 Sep. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-05-11 2026-08-11 2026-08-12 519.6 2468-1113 10.1016/j.comtox.2026.100445 288214787 https://www.sciencedirect.com/science/article/pii/S2468111326000460?via%3Dihub 1 bde1154a-a6b8-11f1-8a94-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50342 RAZ_Kumar_Saurav_2026.pdf RAZ_Kumar_Saurav_2026.pdf 1 67D28B39FD6771705291EA9013FC3391 f18c490ef6d6fad5c51817a0bb30ba591b30102f00ef1ecbb5a1dfeeb283eee6 f7d1ed4d-a6b8-11f1-8a94-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50343 Institut Jožef Stefan 0 0 0