20.500.12556/DiRROS-32159 Association of persistent symptoms after lyme neuroborreliosis and Increased levels of interferon-α in blood Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients followed for 1 year. At study entry, most mediators were highly concentrated in CSF, the site of the infection. Those responses resolved with antibiotic therapy, and associations between CSF cytokines and signs and symptoms of LNB were no longer observed. In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. Highest IFN-α levels corresponded with severe disease. Although the infection serves as the initial trigger, sequelae after antibiotic therapy are associated with unremitting systemic IFN-α levels, consistent with the pathogenic role of this cytokine in interferonopathies in other conditions. persistent symptoms infections lyme neuroborreliosis true false true Angleški jezik Ni določen Na strani revije navedeno: "Because the journal is in the public domain, its usage policy also conforms to conditions set forth by Creative Commons" ter "Emerging Infectious Diseases is an open access journal published by the Centers for Disease Control and Prevention, a U.S. Government agency. The journal is a member in good standing of the Directory of Open Access Journals" External Link(https://wwwnc.cdc.gov/eid/about/general#, 28. 8. 2026) Neznano 2026-08-28 12:12:18 2026-08-28 12:12:19 2026-08-29 04:22:43 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 6. 2023; str. 1091-1101 no. 6 Vol. 29 jun. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1080-6059 10.3201/eid2906.221685 155035907 RAZ_Hernandez_Sergio_A._2023.pdf RAZ_Hernandez_Sergio_A._2023.pdf 1 C6133C84C21502B99E4D30EC2854E03D 3edba7151e57a44773c38438b56c7002573141b7c9b45f6532d71415c5662eca 2d2ba19c-a2ca-11f1-b645-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50160 https://wwwnc.cdc.gov/eid/article/29/6/22-1685_article 1 066a6de3-a2c9-11f1-b645-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=50158 Univerzitetni klinični center Ljubljana 0 0 0