20.500.12556/DiRROS-31913 Catecholaminergic contributions to inhibitory controlfollowing physical fatigue behavioral and neurophysiological findings Acute physical fatigue can impair cognitive control, yet its underlying neurochemical mechanisms remain unclear. This studyinvestigated whether catecholaminergic modulation influences behavioral and neural markers of inhibitory control followingphysical fatigue. Eighteen healthy, recreationally active adults (9 males, 9 females; 23.4 ± 2.2 years) completed a randomized,triple‐blind, placebo‐controlled crossover study. On separate visits, participants received methylphenidate (MPH; 20 mg; adopamine and noradrenaline reuptake inhibitor), reboxetine (REB; 8 mg; a noradrenaline reuptake inhibitor), or placebo.Physical fatigue was induced by repeated bilateral leg extensions to task failure. Cognitive performance was assessed before andafter physical fatigue using a Go/No‐Go task with electroencephalographic recording. Behavioral outcomes included reactiontime and accuracy, while event‐related potentials measured neural stages of response execution and inhibition (N2 and P3).Mixed‐effects models were used for statistical analysis. For No‐Go trials, a significant MPH × Time interaction was observed foraccuracy (p = 0.008), with improved post‐fatigue performance following MPH administration (p = 0.048). At the neural level,MPH was associated with shorter fronto‐central No‐Go N2 latency (p = 0.038) and altered fatigue‐related changes in No‐Go P3latency (p = 0.047). REB did not produce comparable behavioral or neural effects. These findings provide pharmacologicalevidence that catecholaminergic mechanisms contribute to inhibitory control following physical fatigue. The differential effectsof MPH and REB suggest that selective noradrenergic enhancement alone is insufficient to maintain inhibitory control followingphysical fatigue. Instead, the findings implicate broader dopaminergic and noradrenergic mechanisms, potentially involvingalterations in the temporal dynamics of inhibitory processing. brain neurotransmission cognitive control EEG event‐related potentials physical fatigue možganski nevrotransmisija kognitivni nadzor EEG z dogodki povezani potenciali fizična utrujenost true false true Angleški jezik Slovenski jezik © 2026 The Author(s). European Journal of Sport Science published by Wiley‐VCH GmbH on behalf of European College of Sport Science Neznano 2026-08-18 09:32:11 2026-08-18 09:32:12 2026-08-19 03:46:19 0000-00-00 00:00:00 2026 0 0 str. 1-13 iss. 9 Vol. 26 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2026-01-01 612.82:796.01 1746-1391 10.1002/ejsc.70231 288027651 26-08-18-Marusic-101-288027651.pdf 26-08-18-Marusic-101-288027651.pdf 1 768E59856FDCE3433012EF3794A23030 e4001d8fd3b0d06a2bb1e7529dc234ddae9b6fcc049aa8d32af73a68e87e0478 0b6f1b4b-9ad7-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49647 https://onlinelibrary.wiley.com/doi/10.1002/ejsc.70231 1 eea0a324-9ad6-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49646 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0