20.500.12556/DiRROS-31853 Association of clinical and laboratory parameters with appendiceal neoplasms in acute appendicitis a single institution retrospective cohort study Background and Objectives: Appendiceal neoplasms are frequently incidental findings in post-appendectomy histopathology, occurring in approximately 0.7–2.5% of patients with acute appendicitis. This study aimed to evaluate the association between clinical and laboratory parameters and the presence of appendiceal neoplasms in patients presenting with acute appendicitis. Materials and Methods: A retrospective cohort study was conducted, including patients treated at the University Medical Center Ljubljana between 2016 and 2020. Inclusion criteria were patients diagnosed with acute appendicitis who underwent emergency appendectomy, while patients with preoperatively diagnosed appendiceal neoplasms or non-surgical management were excluded. Patients with histopathologically confirmed appendiceal neoplasms were compared with a sample of patients without neoplasms, selected from the same cohort. Logistic regression analysis was performed to assess associations between clinical variables (age, sex, duration of symptoms, CRP, and leukocyte count) and neoplasm presence. Results: Appendiceal neoplasms were identified in 48 patients, corresponding to an analytic prevalence of 4.5% (48 of 1030) and a true prevalence of 1.6% (48 of 3014) among all appendicitis cases. In univariate analysis, age, duration of symptoms, CRP levels, and leukocyte count were significantly associated with neoplasm presence. In multiple logistic regression, higher CRP levels (OR 1.04, 95% CI 1.01–1.08; p = 0.007, per 10 mg/L increase) and lower leukocyte counts (OR 0.91, 95% CI 0.85–0.98, p = 0.012) remained significantly associated with appendiceal neoplasms. ROC analysis demonstrated limited discriminative performance (AUC < 0.70 for both parameters). Conclusions: Elevated CRP levels and lower leukocyte counts were associated with appendiceal neoplasms in patients presenting with acute appendicitis, suggesting a distinct inflammatory profile; however, their clinical utility for preoperative identification appears limited. appendiceal neoplasms appendicitis C-reactive protein leukocyte count clinical deterioration acute appendicitis clinical parameters inflammatory parameters neoplazme slepiča akutno vnetje slepiča vnetni parametri true false true Angleški jezik Slovenski jezik Neznano 2026-08-12 08:46:58 2026-08-12 08:46:59 2026-08-13 03:48:33 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 7. 8. 2026; str. [1]-12 issue 8, [article no.] 1442 Vol. 62 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612.363:616-002.1 1648-9144 10.3390/medicina62081442 287265027 RAZ_Krebs_Mia_2026.pdf RAZ_Krebs_Mia_2026.pdf 1 8F5CFB93A318F880AF1DEF80C9E90560 d63ed8747f98d60e7e6934d97bc63ea302665a1f936c13cd59f903b5bfb1fdef ed659cdb-9619-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49497 https://www.mdpi.com/1648-9144/62/8/1442 1 9f0f5155-9619-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49496 Univerzitetni klinični center Ljubljana 0 0 0