20.500.12556/DiRROS-31627 Detecting subtle cognitive impairment in patients with Parkinson’s disease and normal cognition a novel cognitive control challenge task (C3T) Patients with Parkinson’s disease (PD) often show early deficits in cognitive control, with primary difficulties in flexibility and relatively intact stable representations. The aim of our study was to assess executive function using an ecologically valid approach that combines measures of stability and flexibility. Fourteen patients without cognitive deficits and sixteen comparable control subjects completed a standardized neuropsychological test battery and a newly developed cognitive control challenge task (C3T). We found that the accuracy of C3T performance decreased with age in healthy participants and remained impaired in PD patients regardless of age. In addition, PD patients showed significantly lower overall performance for cognitive control tasks than healthy controls, even when they scored in the normal range on standardized neuropsychological tests. PD Patients responded significantly faster than healthy control subjects regarding flexible cognitive control tasks due to their impulsivity. Correlations showed that the C3T task targets multiple cognitive systems, including working memory, inhibition, and task switching, providing a reliable measure of complex cognitive control. C3T could be a valuable tool for characterizing cognitive deficits associated with PD and appears to be a more sensitive measure than standardized neuropsychological tests. A different assessment approach could potentially detect early signs of the disease and identify opportunities for early intervention with neuroprotective therapies. stable cognitive control flexible cognitive control cognitive control challenge task Parkinson’s disease task switching stabilen kognitivni nadzor prilagodljiv kognitivni nadzor naloga izziva kognitivnega nadzora Parkinsonova bolezen preklapljanje nalog true false true Angleški jezik Slovenski jezik Neznano 2026-08-05 13:16:17 2026-08-05 13:16:17 2026-08-06 04:01:42 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 6. 2023; str. 1-18 iss. 6 Vol. 13 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2076-3425 10.3390/brainsci13060961 156747267 RAZ_Resnik_Robida_Karmen_2023.pdf RAZ_Resnik_Robida_Karmen_2023.pdf 1 D5075971D70E0F277FA3424CC799A5A2 abcef63c4aea2a89d5b0ae85e4d75b0d94a9d9d7f51f7c4d04819d402ce446eb 32129a0f-90bf-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49063 https://www.mdpi.com/2076-3425/13/6/961 1 15504907-90bf-11f1-af5a-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=49062 Univerzitetni klinični center Ljubljana 0 0 0