20.500.12556/DiRROS-31356 Numerical investigation of electroporation in the presence of silica-coated magnetic nanoparticles electric field perturbation and transmembrane voltage enhancement during pulse rise time Electroporation outcomes are governed by the local electric field distribution and transmembrane voltage, both of which may be altered by nanoscale elements positioned near the cell membrane. In this study, we developed a two-dimensional finite-element electromagnetic model to investigate the effect of a membrane-proximal silica-coated superparamagnetic iron oxide nanoparticle cluster during a trapezoidal electroporation pulse. The model couples electric and magnetic field components with a membrane electroporation formulation based on Smoluchowski-type pore-density dynamics. Simulations were performed with and without a nanoparticle positioned 5 nm from the membrane, considering different cytosol and extracellular medium conductivities. The results show that the nanoparticle induces a highly localized perturbation of the electric field, whose magnitude depends on the sampling region and conductivity contrast. Transmembrane voltage is modestly and transiently modulated during pulse rise time, whereas the effect is limited during the pulse plateau. Pore-density analysis further indicates that the nanoparticle does not induce a generalized increase in electroporation-related parameters and may locally reduce pore density near the nanoparticle–membrane interface. Overall, the model identifies transient and conductivity-dependent nanoscale field redistribution caused by membrane-proximal silica-coated magnetic nanoparticles, while highlighting the need for three-dimensional modeling and experimental validation before inferring electroporation enhancement. electroporation finite element analysis magnetic nanoparticles končni elementi analize magnetni nanodelci true false true MDPI Švica Angleški jezik Slovenski jezik © 2026 by the authors. Neznano 2026-07-29 15:06:21 2026-07-29 15:06:21 2026-07-30 03:49:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Soavtor iz Slovenije Slavko Kralj; Opis vira z dne 29. 7. 2026; str. 1-24 iss. 14 Vol. 16 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-05-25 2026-07-06 2026-07-15 535 2076-3417 10.3390/app16147089 286364419 https://www.mdpi.com/2076-3417/16/14/7089 1 4fb19c10-8b4e-11f1-923b-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48512 RAZ_Sieni_Elisabetta_E._2026.pdf RAZ_Sieni_Elisabetta_E._2026.pdf 1 E17F82BA1BE753E7857D9B0156DC64A4 579614e338724e4ff36ef5d78348561af012781b349c5e24708c7340e5d944bc 9f3554fb-8b4e-11f1-923b-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=48513 Institut Jožef Stefan 0 0 0